PMID- 28838344
OWN - NLM
STAT- MEDLINE
DCOM- 20180430
LR  - 20181023
IS  - 1165-158X (Electronic)
IS  - 0145-5680 (Linking)
VI  - 63
IP  - 7
DP  - 2017 Aug 15
TI  - Inflammatory and immune responses to a 3-day period of downhill running in active 
      females.
PG  - 76-83
LID - 10.14715/cmb/2017.63.7.13 [doi]
AB  - Exercise-induced muscle damage (EIMD) is accompanied by inflammatory and immune 
      responses. However, due to the repeated bout effect, there will probably be less 
      EIMD. Hence, the purpose was to investigate inflammatory and immune responses 
      over a three-day period of downhill running in active females. Eleven moderately 
      trained healthy females performed three 60-minute bouts of downhill running in 
      -13.5% grade, separated by 24 hours, at a speed eliciting 70-80% of their VO2peak 
      on level grade. Delayed onset muscle soreness (DOMS), range of motion (ROM) and 
      maximum knee isotonic strength (1RM) were measured pre- and two-hour post every 
      bout. Blood variables, including CBC, serum lactate dehydrogenase (LDH), creatine 
      kinase (CK), myoglobin (Mb), IL-10, IL-6 and Monocyte chemoattractant protein-1 
      (MCP-1) were measured at 1 hour before the first bout and two hours after every 
      bout. Data was analysed by repeated measure ANOVA (P<0.05). Although CK, LDH, Mb, 
      IL-10, IL-6, MCP-1, total leukocyte count, monocytes and neutrophils increased 
      significantly following the first bout, CK, LDH, Mb, IL-10, monocytes and 
      neutrophils were only significantly higher following the third bout compared to 
      the baseline (all P<0.05). Moreover, IL-10 and IL-6 decreased following the 
      second and third bouts compared to the first bout (P<0.05). In comparison with 
      the baseline, lymphocytes decreased after the second bout, DOMS increased 
      following the second and third bouts, 1RM decreased following the first and 
      second bouts (all P<0.05). ROM showed no significant difference. The three-day 
      period of downhill running did not exacerbate EIMD and inflammatory response was 
      partly attenuated.
FAU - Jafariyan, S
AU  - Jafariyan S
AD  - Razi University, Kermanshah, Iran.
FAU - Monazzami, A
AU  - Monazzami A
AD  - Department of Sport Physiology, Faculty of Sport Sciences,Razi University, 
      Kermanshah, Iran.
FAU - Nikousefat, Z
AU  - Nikousefat Z
AD  - Department of Clinical Sciences, Faculty of Veterinary, Razi University, 
      Kermanshah, Iran.
FAU - Nobahar, M
AU  - Nobahar M
AD  - Payame Noor University, Kermanshah, Iran.
FAU - Yari, K
AU  - Yari K
AD  - Medical Biology Research Center, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20170815
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (Cytokines)
RN  - 0 (Myoglobin)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 2.7.3.2 (Creatine Kinase)
SB  - IM
MH  - Adult
MH  - Blood Cell Count
MH  - Creatine Kinase/blood
MH  - Cytokines/blood
MH  - Female
MH  - Heart Rate/physiology
MH  - Humans
MH  - *Immunity
MH  - Inflammation/blood/*pathology
MH  - L-Lactate Dehydrogenase/blood
MH  - Muscle Fatigue/physiology
MH  - Myoglobin/blood
MH  - Running/*physiology
OTO - NOTNLM
OT  - Cytokine
OT  - Eccentric exercise
OT  - IL-10.
OT  - MCP-1
OT  - Muscle damage
OT  - Repeated bout effect
EDAT- 2017/08/26 06:00
MHDA- 2018/05/01 06:00
CRDT- 2017/08/26 06:00
PHST- 2017/04/04 00:00 [received]
PHST- 2017/05/17 00:00 [accepted]
PHST- 2017/05/21 00:00 [revised]
PHST- 2017/08/26 06:00 [entrez]
PHST- 2017/08/26 06:00 [pubmed]
PHST- 2018/05/01 06:00 [medline]
AID - 10.14715/cmb/2017.63.7.13 [doi]
PST - epublish
SO  - Cell Mol Biol (Noisy-le-grand). 2017 Aug 15;63(7):76-83. doi: 
      10.14715/cmb/2017.63.7.13.