PMID- 28838743
OWN - NLM
STAT- MEDLINE
DCOM- 20190109
LR  - 20190109
IS  - 1878-1780 (Electronic)
IS  - 1262-3636 (Linking)
VI  - 44
IP  - 4
DP  - 2018 Sep
TI  - Total serum bilirubin and 8-year incident type 2 diabetes mellitus: The Korean 
      Genome and Epidemiology Study.
PG  - 346-353
LID - S1262-3636(17)30477-9 [pii]
LID - 10.1016/j.diabet.2017.07.004 [doi]
AB  - AIM: In this study, the impact of serum bilirubin on new-onset type 2 diabetes 
      mellitus (T2DM) in Korean adults was investigated. METHODS: Data were obtained 
      from the Korean Genome and Epidemiology Study (KoGES), a population-based 
      prospective cohort study. The study enrolled 8650 adults (4015 men and 4635 
      women), aged 40 to 69 years, who underwent a mean follow-up of 8.4 years. The 
      study population was divided into quartiles (Q) of serum bilirubin levels, with 
      cut-off points at 0.46, 0.61 and 0.82mg/dL for men, and 0.35, 0.47 and 0.61mg/dL 
      for women. T2DM was defined based on the following data: fasting blood 
      glucose>/=7.0mmol/L, HbA(1c) level>/=6.5% or 2-h plasma glucose>/=11.1mmol/L during a 
      75-g oral glucose tolerance test. RESULTS: Over the mean 8.4-year follow-up, 786 
      participants (9.1%) developed T2DM. Compared with Q1, the odds ratios (ORs) and 
      95% confidence intervals (CIs) for T2DM incidence were 0.52 (0.36-0.74) in men 
      and 0.56 (0.38-0.83) in women aged >/=50 years, respectively, in the highest Q 
      group after adjusting for possible confounding factors. These significant results 
      persisted in those with impaired glucose tolerance and impaired fasting glucose. 
      CONCLUSION: The results of this study reveal a protective role for serum total 
      bilirubin on new-onset T2DM in Korean men and women. In addition, serum total 
      bilirubin had favourable effects on new-onset T2DM in those with impaired glucose 
      tolerance and impaired fasting glucose.
CI  - Copyright (c) 2017 Elsevier Masson SAS. All rights reserved.
FAU - Kwon, Y-J
AU  - Kwon YJ
AD  - Department of Family Medicine, Yonsei University College of Medicine, Yong-in 
      Severance Hospital, 225 Geumhakno, Cheoin-gu, Yongin-si, 17046 Gyeonggi-do, 
      Republic of Korea; Department of Medicine, Graduate School of Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Lee, Y-J
AU  - Lee YJ
AD  - Department of Family Medicine, Gangnam Severance Hospital, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Park, B-J
AU  - Park BJ
AD  - Department of Family Medicine, Yonsei University College of Medicine, Yong-in 
      Severance Hospital, 225 Geumhakno, Cheoin-gu, Yongin-si, 17046 Gyeonggi-do, 
      Republic of Korea.
FAU - Hong, K-W
AU  - Hong KW
AD  - TheragenEtex BioInstitue Co., Ltd., Suwon, Gyunggi, Republic of Korea.
FAU - Jung, D-H
AU  - Jung DH
AD  - Department of Family Medicine, Yonsei University College of Medicine, Yong-in 
      Severance Hospital, 225 Geumhakno, Cheoin-gu, Yongin-si, 17046 Gyeonggi-do, 
      Republic of Korea. Electronic address: balsan2@yuhs.ac.
LA  - eng
PT  - Journal Article
DEP - 20170831
PL  - France
TA  - Diabetes Metab
JT  - Diabetes & metabolism
JID - 9607599
RN  - 0 (Blood Glucose)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bilirubin/*blood
MH  - Blood Glucose
MH  - Diabetes Mellitus, Type 2/*blood/*epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Republic of Korea/epidemiology
OTO - NOTNLM
OT  - Bilirubin
OT  - Impaired fasting glucose
OT  - Impaired glucose tolerance
OT  - KoGES
OT  - Type 2 diabetes mellitus
EDAT- 2017/08/26 06:00
MHDA- 2019/01/10 06:00
CRDT- 2017/08/26 06:00
PHST- 2017/04/10 00:00 [received]
PHST- 2017/07/07 00:00 [revised]
PHST- 2017/07/14 00:00 [accepted]
PHST- 2017/08/26 06:00 [pubmed]
PHST- 2019/01/10 06:00 [medline]
PHST- 2017/08/26 06:00 [entrez]
AID - S1262-3636(17)30477-9 [pii]
AID - 10.1016/j.diabet.2017.07.004 [doi]
PST - ppublish
SO  - Diabetes Metab. 2018 Sep;44(4):346-353. doi: 10.1016/j.diabet.2017.07.004. Epub 
      2017 Aug 31.