PMID- 28838848
OWN - NLM
STAT- MEDLINE
DCOM- 20180716
LR  - 20180716
IS  - 1098-8823 (Print)
IS  - 1098-8823 (Linking)
VI  - 133
DP  - 2017 Nov
TI  - Omega-3 polyunsaturated fatty acids reduce vascular tone and inflammation in 
      human saphenous vein.
PG  - 29-34
LID - S1098-8823(17)30039-4 [pii]
LID - 10.1016/j.prostaglandins.2017.08.007 [doi]
AB  - Dietary intake of omega-3 polyunsaturated fatty acids, including eicosapentaenoic 
      acid (EPA) and docosahexaenoic acid (DHA), has been reported to have beneficial 
      cardiovascular effects. However, little is known about the effect of EPA and DHA 
      on human vascular tone. Therefore, the aim of this study is to evaluate the 
      effect of EPA and DHA on vascular tone of the human saphenous vein (SV) obtained 
      from patients undergoing coronary bypass operation under normal and inflammatory 
      conditions. Moreover, we aimed to investigate the effect of EPA and DHA on the 
      release of inflammatory mediators from SV. Pretreatment of SV with EPA and DHA 
      (100muM, 18h) decreased the contractile response of SV to norepinephrine (NE) 
      under normal and inflammatory conditions. Moreover, EPA and DHA pretreatment 
      diminished increased Monocyte Chemoattractant Protein-1 (MCP-1) and Tumor 
      Necrosis Factor-alpha (TNF-alpha) release from SV under inflammatory conditions. In 
      conclusion, our results suggest that EPA and DHA pretreatment may be beneficial 
      to counteract graft vasospasm and vascular inflammation in SV which are important 
      factors in graft failure development. Therefore, dietary intake of EPA and DHA 
      may have potential clinical applications in improving coronary bypass graft 
      patency.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Daci, Armond
AU  - Daci A
AD  - Istanbul University, Faculty of Pharmacy, Department of Pharmacology, Istanbul, 
      Turkey.
FAU - Ozen, Gulsev
AU  - Ozen G
AD  - INSERM, U1148, CHU. Bichat, Paris, 75018, France.
FAU - Uyar, Imran
AU  - Uyar I
AD  - Istanbul University, Faculty of Pharmacy, Department of Pharmacology, Istanbul, 
      Turkey.
FAU - Civelek, Erkan
AU  - Civelek E
AD  - Istanbul University, Faculty of Pharmacy, Department of Pharmacology, Istanbul, 
      Turkey.
FAU - Yildirim, F Ilkay Alp
AU  - Yildirim FIA
AD  - Istanbul University, Faculty of Pharmacy, Department of Pharmacology, Istanbul, 
      Turkey.
FAU - Durman, Deniz Kaleli
AU  - Durman DK
AD  - Istanbul University, Faculty of Pharmacy, Department of Pharmacology, Istanbul, 
      Turkey.
FAU - Teskin, Onder
AU  - Teskin O
AD  - Biruni University, Department of Cardiovascular Surgery, Istanbul, Turkey.
FAU - Norel, Xavier
AU  - Norel X
AD  - INSERM, U1148, CHU. Bichat, Paris, 75018, France; University Paris Nord, Sorbonne 
      Paris-Cite, UMR-S1148, Paris, 75018, France.
FAU - Uydes-Dogan, B Sonmez
AU  - Uydes-Dogan BS
AD  - Istanbul University, Faculty of Pharmacy, Department of Pharmacology, Istanbul, 
      Turkey.
FAU - Topal, Gokce
AU  - Topal G
AD  - Istanbul University, Faculty of Pharmacy, Department of Pharmacology, Istanbul, 
      Turkey. Electronic address: gokce_topal@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20170830
PL  - United States
TA  - Prostaglandins Other Lipid Mediat
JT  - Prostaglandins & other lipid mediators
JID - 9808648
RN  - 0 (Inflammation Mediators)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - AAN7QOV9EA (Eicosapentaenoic Acid)
SB  - IM
MH  - Aged
MH  - Docosahexaenoic Acids/*pharmacology/therapeutic use
MH  - Eicosapentaenoic Acid/*pharmacology/therapeutic use
MH  - Female
MH  - Humans
MH  - Inflammation/drug therapy
MH  - Inflammation Mediators/metabolism
MH  - Male
MH  - Middle Aged
MH  - Saphenous Vein/*drug effects/*physiology
MH  - Vasodilation/drug effects
OTO - NOTNLM
OT  - Human saphenous vein
OT  - Inflammation
OT  - Omega-3 polyunsaturated fatty acids
OT  - Vascular tone
EDAT- 2017/08/26 06:00
MHDA- 2018/07/17 06:00
CRDT- 2017/08/26 06:00
PHST- 2017/02/23 00:00 [received]
PHST- 2017/06/20 00:00 [revised]
PHST- 2017/08/09 00:00 [accepted]
PHST- 2017/08/26 06:00 [pubmed]
PHST- 2018/07/17 06:00 [medline]
PHST- 2017/08/26 06:00 [entrez]
AID - S1098-8823(17)30039-4 [pii]
AID - 10.1016/j.prostaglandins.2017.08.007 [doi]
PST - ppublish
SO  - Prostaglandins Other Lipid Mediat. 2017 Nov;133:29-34. doi: 
      10.1016/j.prostaglandins.2017.08.007. Epub 2017 Aug 30.