PMID- 28839207
OWN - NLM
STAT- MEDLINE
DCOM- 20190411
LR  - 20190411
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Aug 24
TI  - Relationships between serum-induced AhR bioactivity or mitochondrial inhibition 
      and circulating polychlorinated biphenyls (PCBs).
PG  - 9383
LID - 10.1038/s41598-017-09774-1 [doi]
LID - 9383
AB  - Metabolic syndrome and mitochondrial dysfunction have been linked to elevated 
      serum levels of persistent organic pollutants (POPs). However, it is not clear 
      which specific POPs contribute to aryl hydrocarbon receptor (AhR)-dependent 
      bioactivity or inhibit mitochondrial function in human subjects. Here, we 
      measured the cumulative bioactivity of AhR ligand mixture (AhR bioactivity) and 
      the effects on mitochondrial function (ATP concentration) in recombinant 
      Hepa1c1c7 cells incubated with raw serum samples obtained from 911 elderly 
      subjects in the Prospective Investigation of the Vasculature in Uppsala Seniors 
      (PIVUS) cohort. Plasma concentrations of 30 POPs and plastic chemicals have 
      previously been determined in the same PIVUS subjects. Linear regression analysis 
      demonstrated that total toxic equivalence (TEQ) values and polychlorinated 
      biphenyls (PCBs) were significantly correlated with AhR bioactivity (positively) 
      and ATP concentration (negatively). Serum AhR bioactivities were positively 
      associated with some PCBs, regardless of their dioxin-like properties, but only 
      dioxin-like PCBs stimulated AhR bioactivity. By contrast, PCBs mediated a 
      reduction in ATP content independently of their dioxin-like properties. This 
      study suggests that AhR bioactivity and ATP concentrations in serum-treated cells 
      may be valuable surrogate biomarkers of POP exposure and could be useful for the 
      estimation of the effects of POPs on human health.
FAU - Park, Wook Ha
AU  - Park WH
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      02447, Korea.
FAU - Kang, Sora
AU  - Kang S
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      02447, Korea.
FAU - Lee, Hong Kyu
AU  - Lee HK
AD  - Department of Internal Medicine, College of Medicine, Eulji University, Seoul, 
      01830, Korea.
FAU - Salihovic, Samira
AU  - Salihovic S
AD  - MTM Research Centre, School of Science and Technology, Orebro University, Orebro, 
      SE-701 82, Sweden.
FAU - Bavel, Bert van
AU  - Bavel BV
AD  - MTM Research Centre, School of Science and Technology, Orebro University, Orebro, 
      SE-701 82, Sweden.
FAU - Lind, P Monica
AU  - Lind PM
AD  - Occupational and Environmental Medicine, Uppsala University, Uppsala, SE-751 05, 
      Sweden.
FAU - Pak, Youngmi Kim
AU  - Pak YK
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      02447, Korea. ykpak@khu.ac.kr.
FAU - Lind, Lars
AU  - Lind L
AD  - Department of Medicine, Cardiovascular Epidemiology, Uppsala University, SE-751 
      05, Uppsala, Sweden. lars.lind@medsci.uu.se.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170824
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Biomarkers)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adenosine Triphosphate/blood
MH  - Aged
MH  - Biomarkers
MH  - Environmental Exposure
MH  - Female
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/blood/epidemiology/metabolism
MH  - Mitochondria/*metabolism
MH  - Polychlorinated Biphenyls/*blood
MH  - Receptors, Aryl Hydrocarbon/*metabolism
MH  - Sweden/epidemiology
PMC - PMC5571204
COIS- The authors declare that they have no competing interests.
EDAT- 2017/08/26 06:00
MHDA- 2019/04/12 06:00
PMCR- 2017/08/24
CRDT- 2017/08/26 06:00
PHST- 2017/03/22 00:00 [received]
PHST- 2017/07/28 00:00 [accepted]
PHST- 2017/08/26 06:00 [entrez]
PHST- 2017/08/26 06:00 [pubmed]
PHST- 2019/04/12 06:00 [medline]
PHST- 2017/08/24 00:00 [pmc-release]
AID - 10.1038/s41598-017-09774-1 [pii]
AID - 9774 [pii]
AID - 10.1038/s41598-017-09774-1 [doi]
PST - epublish
SO  - Sci Rep. 2017 Aug 24;7(1):9383. doi: 10.1038/s41598-017-09774-1.