PMID- 28840001
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 9
IP  - 7
DP  - 2017 Jul
TI  - Bronchial hyperreactivity in perimenstrual asthma is associated with increased 
      Th-2 response in lower airways.
PG  - 2015-2021
LID - 10.21037/jtd.2017.06.121 [doi]
AB  - BACKGROUND: Perimenstrual asthma (PMA) is a commonly observed, usually 
      difficult-to-treat asthma phenotype. The mechanisms underlying this phenomenon 
      remain unexplained. The aim of the study was to assess the degree of airway 
      hyperresponsiveness and its relationship to proinflammatory cytokines 
      concentration in lower airways of PMA compared to non-PMA patients. METHODS: 
      Premenopausal women with regular menstrual cycles diagnosed as: PMA (n=12), 
      non-PMA asthmatics (n=9), and healthy controls (n=10) were prospectively followed 
      for 10 weeks over two consecutive menstrual cycles. The bronchial responsiveness 
      (BR) test to methacholine was performed in each subject prior to the study. The 
      serum for total immunoglobulin E (IgE) concentrations was taken and sputum was 
      induced in the 26th day of each of the two cycles. Sputum concentration of 
      eotaxin, IL-4 and IL-10 were measured by ELISA. RESULTS: Levels of BR to 
      metacholine as well, as total blood IgE concentrations in PMA subjects were 
      significantly higher than in non-PMA asthmatics and healthy controls (P=0.001, 
      P=0.022 respectively) and correlated with each other (P=0.030; r =-0.65). Sputum 
      eotaxin and IL-4 concentrations in luteal phase were increased in PMA patients 
      when compared with non-PMA asthmatics (P=0.016; P=0.041, respectively) and 
      healthy subjects (P<0.001 both cytokines). No differences for the sputum levels 
      of IL-10 among studied groups were seen. CONCLUSIONS: BR level in perimenstrual 
      asthma is higher than in non-PMA asthmatics and correlates with increased total 
      IgE serum concentration. The increased level of BR in PMA patients is associated 
      with a shift in the type-1/type-2 cytokine balance toward a type-2 response.
FAU - Skoczynski, Szymon
AU  - Skoczynski S
AD  - Department of Pneumology, School of Medicine in Katowice, Medical University of 
      Silesia, Katowice, Poland.
FAU - Semik-Orzech, Aleksandra
AU  - Semik-Orzech A
AD  - Department of Pneumology, School of Medicine in Katowice, Medical University of 
      Silesia, Katowice, Poland.
FAU - Sozanska, Ewa
AU  - Sozanska E
AD  - Department of Pneumology, School of Medicine in Katowice, Medical University of 
      Silesia, Katowice, Poland.
FAU - Szanecki, Wojciech
AU  - Szanecki W
AD  - Department of Gynaecology, School of Medicine in Katowice, Medical University of 
      Silesia, Katowice, Poland.
FAU - Kolodziejczyk, Krzysztof
AU  - Kolodziejczyk K
AD  - Specialistic Medical Practice Krzysztof Kolodziejczyk, Katowice, Poland.
FAU - Radziewicz-Winnicki, Igor
AU  - Radziewicz-Winnicki I
AD  - Faculty of Medicine University of Rzeszow, Rzeszow, Poland.
FAU - Witek, Andrzej
AU  - Witek A
AD  - Department of Gynaecology, School of Medicine in Katowice, Medical University of 
      Silesia, Katowice, Poland.
FAU - Pierzchala, Wladyslaw
AU  - Pierzchala W
AD  - Department of Pneumology, School of Medicine in Katowice, Medical University of 
      Silesia, Katowice, Poland.
FAU - Barczyk, Adam
AU  - Barczyk A
AD  - Department of Pneumology, School of Medicine in Katowice, Medical University of 
      Silesia, Katowice, Poland.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC5542973
OTO - NOTNLM
OT  - Bronchial hyperreactivity
OT  - cytokines
OT  - perimenstrual asthma
COIS- Conflicts of Interest: The results of the study were presented during the 
      European Respiratory Society in Munich (Germany), 6-10.09.2014 (Eur Respir J 
      Suppl 2014;44:2).
EDAT- 2017/08/26 06:00
MHDA- 2017/08/26 06:01
PMCR- 2017/07/01
CRDT- 2017/08/26 06:00
PHST- 2017/08/26 06:00 [entrez]
PHST- 2017/08/26 06:00 [pubmed]
PHST- 2017/08/26 06:01 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - jtd-09-07-2015 [pii]
AID - 10.21037/jtd.2017.06.121 [doi]
PST - ppublish
SO  - J Thorac Dis. 2017 Jul;9(7):2015-2021. doi: 10.21037/jtd.2017.06.121.