PMID- 28840062
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 2152-5250 (Print)
IS  - 2152-5250 (Electronic)
IS  - 2152-5250 (Linking)
VI  - 8
IP  - 4
DP  - 2017 Jul
TI  - Recent Progress in Vascular Aging: Mechanisms and Its Role in Age-related 
      Diseases.
PG  - 486-505
LID - 10.14336/AD.2017.0507 [doi]
AB  - As with many age-related diseases including vascular dysfunction, age is 
      considered an independent and crucial risk factor. Complicated alterations of 
      structure and function in the vasculature are linked with aging hence, 
      understanding the underlying mechanisms of age-induced vascular 
      pathophysiological changes holds possibilities for developing clinical diagnostic 
      methods and new therapeutic strategies. Here, we discuss the underlying molecular 
      mediators that could be involved in vascular aging, e.g., the renin-angiotensin 
      system and pro-inflammatory factors, metalloproteinases, calpain-1, monocyte 
      chemoattractant protein-1 (MCP-1) and TGFbeta-1 as well as the potential roles of 
      testosterone and estrogen. We then relate all of these to clinical manifestations 
      such as vascular dementia and stroke in addition to reviewing the existing 
      clinical measurements and potential interventions for age-related vascular 
      dysfunction.
FAU - Xu, Xianglai
AU  - Xu X
AD  - 1Zhongshan Hospital, Fudan University, Shanghai 200032, China.
AD  - 2Department of Pharmacology and Neuroscience, University of North Texas Health 
      Science Center at Fort Worth, TX 76107, USA.
FAU - Wang, Brian
AU  - Wang B
AD  - 2Department of Pharmacology and Neuroscience, University of North Texas Health 
      Science Center at Fort Worth, TX 76107, USA.
FAU - Ren, Changhong
AU  - Ren C
AD  - 2Department of Pharmacology and Neuroscience, University of North Texas Health 
      Science Center at Fort Worth, TX 76107, USA.
AD  - 4Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University. 
      Beijing, China.
FAU - Hu, Jiangnan
AU  - Hu J
AD  - 2Department of Pharmacology and Neuroscience, University of North Texas Health 
      Science Center at Fort Worth, TX 76107, USA.
FAU - Greenberg, David A
AU  - Greenberg DA
AD  - 5Buck Institute for Research on Aging, Novato, CA 94945, USA.
FAU - Chen, Tianxiang
AU  - Chen T
AD  - 6Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong 
      University, Shanghai, China.
FAU - Xie, Liping
AU  - Xie L
AD  - 3Department of Urology, the First Affiliated Hospital, Zhejiang University, 
      Zhejiang Province, China.
FAU - Jin, Kunlin
AU  - Jin K
AD  - 2Department of Pharmacology and Neuroscience, University of North Texas Health 
      Science Center at Fort Worth, TX 76107, USA.
LA  - eng
GR  - R21 NS084148/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20170721
PL  - United States
TA  - Aging Dis
JT  - Aging and disease
JID - 101540533
PMC - PMC5524810
OTO - NOTNLM
OT  - arterial stiffness
OT  - dementia
OT  - endothelial dysfunction
OT  - stroke
OT  - vascular aging
EDAT- 2017/08/26 06:00
MHDA- 2017/08/26 06:01
PMCR- 2017/07/01
CRDT- 2017/08/26 06:00
PHST- 2016/12/07 00:00 [received]
PHST- 2017/05/07 00:00 [accepted]
PHST- 2017/08/26 06:00 [entrez]
PHST- 2017/08/26 06:00 [pubmed]
PHST- 2017/08/26 06:01 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - ad-8-4-486 [pii]
AID - 10.14336/AD.2017.0507 [doi]
PST - epublish
SO  - Aging Dis. 2017 Jul 21;8(4):486-505. doi: 10.14336/AD.2017.0507. eCollection 2017 
      Jul.