PMID- 28840397 OWN - NLM STAT- MEDLINE DCOM- 20180720 LR - 20181113 IS - 1615-2573 (Electronic) IS - 0910-8327 (Print) IS - 0910-8327 (Linking) VI - 33 IP - 2 DP - 2018 Feb TI - Right ventricular involvement evaluated by cardiac magnetic resonance imaging predicts mortality in patients with light chain amyloidosis. PG - 170-179 LID - 10.1007/s00380-017-1043-y [doi] AB - Few studies have focused on right ventricular (RV) involvement in cardiac amyloidosis (CA). We investigated the prognostic value of RV assessment by cardiovascular magnetic resonance (CMR) in CA. In 2011-2014, consecutive patients with suspected CA referred for CMR were retrospectively evaluated. Demographic and baseline clinical characteristics were collected. Healthy volunteers were matched for sex and age and served as controls. All subjects underwent a contrast-enhanced CMR examination. RV size, function, and late gadolinium enhancement (LGE) were analyzed. All deaths during follow-up were recorded. Sixty-one patients [37 males (60.7%), age 60 +/- 11 years] were included; CA was diagnosed in 47 (77.0%) patients. CA patients displayed decreased biventricular ejection fraction, elevated left ventricular mass index, and increased biventricular end-systolic volume index (ESVi) compared with controls. A total of 27 deaths (57.4%) occurred in the CA group at 21-month median follow-up. Multivariable analysis demonstrated that RVESVi (HR 1.033, 95% CI 1.004-1.063, P = 0.026) and RV-LGE (HR 2.814, 95% CI 1.063-7.450, P = 0.037) were independent predictors of mortality in CA. For all amyloid patients, log NT-proBNP (HR 3.412; 95% CI 1.484-7.845; P = 0.004) and RV-LGE (HR 4.149; 95% CI 1.623-10.607; P = 0.003) were identified as independent predictors. RVESVi and RV-LGE are independent predictors of survival and evaluation of RV by CMR enables risk stratification in patients with CA. FAU - Wan, Ke AU - Wan K AD - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China. FAU - Sun, Jiayu AU - Sun J AD - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China. FAU - Han, Yuchi AU - Han Y AD - Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA. FAU - Luo, Yong AU - Luo Y AD - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China. FAU - Liu, Hong AU - Liu H AD - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China. FAU - Yang, Dan AU - Yang D AD - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China. FAU - Cheng, Wei AU - Cheng W AD - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China. FAU - Zhang, Qing AU - Zhang Q AD - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China. FAU - Zeng, Zhi AU - Zeng Z AD - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China. FAU - Chen, Yucheng AU - Chen Y AD - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China. chenyucheng2003@126.com. LA - eng GR - 81571638/National Natural Science Foundation of China/ GR - 81271531/National Natural Science Foundation of China/ GR - 2013SZ0013/the Science & Technology Department in the Sichuan Province/ PT - Journal Article DEP - 20170824 PL - Japan TA - Heart Vessels JT - Heart and vessels JID - 8511258 SB - IM MH - Aged MH - Amyloidosis/complications/*diagnosis/mortality MH - China/epidemiology MH - Female MH - Heart Ventricles/*diagnostic imaging/physiopathology MH - Humans MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - Predictive Value of Tests MH - Prognosis MH - Retrospective Studies MH - Stroke Volume/*physiology MH - Survival Rate/trends MH - Ventricular Dysfunction, Right/*diagnosis/etiology/physiopathology MH - Ventricular Function, Right/*physiology PMC - PMC5766713 OTO - NOTNLM OT - Cardiac amyloidosis OT - Cardiovascular magnetic resonance OT - Right ventricular OT - Survival COIS- CONFLICT OF INTEREST: The authors have no conflict of interest to disclose. FUNDING: This study was partly supported by the National Natural Science Foundation of China (Grant Nos. 81571638, 81271531) and the Science and Technology Department in the Sichuan Province (Project Number: 2013SZ0013). EDAT- 2017/08/26 06:00 MHDA- 2018/07/22 06:00 PMCR- 2017/08/24 CRDT- 2017/08/26 06:00 PHST- 2016/12/14 00:00 [received] PHST- 2017/08/18 00:00 [accepted] PHST- 2017/08/26 06:00 [pubmed] PHST- 2018/07/22 06:00 [medline] PHST- 2017/08/26 06:00 [entrez] PHST- 2017/08/24 00:00 [pmc-release] AID - 10.1007/s00380-017-1043-y [pii] AID - 1043 [pii] AID - 10.1007/s00380-017-1043-y [doi] PST - ppublish SO - Heart Vessels. 2018 Feb;33(2):170-179. doi: 10.1007/s00380-017-1043-y. Epub 2017 Aug 24.