PMID- 2884326
OWN - NLM
STAT- MEDLINE
DCOM- 19870709
LR  - 20190912
IS  - 0731-3810 (Print)
IS  - 0731-3810 (Linking)
VI  - 25
IP  - 1-2
DP  - 1987
TI  - A case of MAO inhibitor/MDMA interaction: agony after ecstasy.
PG  - 149-59
AB  - After ingesting 3,4-methylene-dioxy-methamphetamine (MDMA) and the monoamine 
      oxidase (MAO) inhibitor phenelzine, a 50 year old male developed marked 
      hypertension, diaphoresis, altered mental status, and hypertonicity lasting 5-6 
      hours. This clinical course is typical of interaction between MAO inhibitors and 
      some sympathomimetics including amphetamines. Such interaction has not previously 
      been described involving MDMA. Sympathomimetic-MAO inhibitor interactions can 
      cause excessive release of endogenous bioactive amines (e.g. norepinephrine, 
      serotonin). Hypertensive crisis, intracranial hemorrhage, hypertonicity, and 
      severe hyperthermia have occurred due to sympathomimetic-MAO inhibitor 
      interactions. MDMA shares structural and pharmacologic features with other agents 
      capable of causing this interaction, and this case suggests that MDMA can cause 
      significant toxicity in patients taking MAO inhibitors.
FAU - Smilkstein, M J
AU  - Smilkstein MJ
FAU - Smolinske, S C
AU  - Smolinske SC
FAU - Rumack, B H
AU  - Rumack BH
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Toxicol Clin Toxicol
JT  - Journal of toxicology. Clinical toxicology
JID - 8213460
RN  - 0 (Amphetamines)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - O408N561GF (Phenelzine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*poisoning
MH  - Amphetamines/*poisoning
MH  - Drug Interactions
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Phenelzine/*poisoning
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
AID - 10.3109/15563658708992620 [doi]
PST - ppublish
SO  - J Toxicol Clin Toxicol. 1987;25(1-2):149-59. doi: 10.3109/15563658708992620.