PMID- 28843428
OWN - NLM
STAT- MEDLINE
DCOM- 20180522
LR  - 20221207
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1674
DP  - 2017 Nov 1
TI  - Association of matrix metalloproteinase-3 gene 5A/6A polymorphism with the 
      recurrence of ischemic stroke: A prospective observational study.
PG  - 55-61
LID - S0006-8993(17)30345-1 [pii]
LID - 10.1016/j.brainres.2017.08.009 [doi]
AB  - Studies have demonstrated that matrix metalloproteinase-3 (MMP-3) is involved in 
      the development and progression of atherosclerosis. However, there is no 
      information available on the association of MMP-3 5A/6A polymorphism with 
      recurrent ischemic stroke (IS) in different IS subtypes. We investigated the 
      potential associations between MMP-3 serum level and -1171 5A/6A polymorphism and 
      the recurrence of IS in a Chinese population. Consecutive acute first-ever IS 
      patients were enrolled between August 2008 and October 2013. The genotypes of 
      MMP-3 5A/6A polymorphism were determined using polymerase chain 
      reaction-restriction fragment length polymorphism. IS recurrence was monitored 
      after the index event and multivariate Cox proportional hazards model was 
      constructed to identify factors related to future IS recurrence. A total of 1282 
      eligible patients were enrolled. During a 2-year follow-up period, 157 (12.25%) 
      patients had recurrent events. MMP-3 level was significantly higher in patients 
      with 5A/6A or 5A/5A genotype (22.72+/-7.29ng/ul) than in patients with 6A/6A 
      genotype (20.48+/-7.58ng/ul), P<0.001. No interaction between MMP-3 5A/6A 
      polymorphism and the risk of recurrence in total IS patients was found. The 
      variant 5A/6A+5A/5A genotype and the 5A allele were significantly associated with 
      a high risk of recurrence for large-artery atherosclerosis (LAA) 
      (multivariate-adjusted, P=0.002, 0.001, respectively), but not for small-artery 
      occlusion and cardioembolism. Our finding showed that MMP-3 5A/6A may be a useful 
      biomarker for predicting recurrence for LAA stroke patients and 5A allele carrier 
      may bear a higher risk of recurrence among patients with the subtype of LAA.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Huang, Xiaoya
AU  - Huang X
AD  - Department of Neurology, Wenzhou Central Hospital & Dingli Clinical Institute of 
      Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
FAU - Ye, Qiang
AU  - Ye Q
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang, PR China.
FAU - Zhang, Zheng
AU  - Zhang Z
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang, PR China.
FAU - Huang, Xiangdong
AU  - Huang X
AD  - Department of Neurology, Wenzhou Central Hospital & Dingli Clinical Institute of 
      Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
FAU - Zhu, Zhenguo
AU  - Zhu Z
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang, PR China.
FAU - Chen, Yanyan
AU  - Chen Y
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang, PR China.
FAU - Li, Jia
AU  - Li J
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang, PR China.
FAU - Chen, Siyan
AU  - Chen S
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang, PR China.
FAU - Xia, Niange
AU  - Xia N
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang, PR China.
FAU - Mao, Xinlei
AU  - Mao X
AD  - Department of Neurology, Wenzhou Central Hospital & Dingli Clinical Institute of 
      Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
FAU - Han, Liya
AU  - Han L
AD  - Department of Neurology, Wenzhou Central Hospital & Dingli Clinical Institute of 
      Wenzhou Medical University, Wenzhou, Zhejiang, PR China. Electronic address: 
      wzeyhly@126.com.
FAU - Ye, Zusen
AU  - Ye Z
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang, PR China. Electronic address: zusenye@163.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20170824
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Asian People/genetics
MH  - Atherosclerosis/genetics/physiopathology
MH  - Brain Ischemia/enzymology/*genetics
MH  - Cerebral Infarction/genetics
MH  - China
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics/*metabolism
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Prospective Studies
MH  - Recurrence
MH  - Stroke/epidemiology/*genetics
OTO - NOTNLM
OT  - Genotype
OT  - Ischemic stroke
OT  - Matrix metalloproteinase
OT  - Polymorphism
OT  - Recurrence
EDAT- 2017/08/28 06:00
MHDA- 2018/05/23 06:00
CRDT- 2017/08/28 06:00
PHST- 2017/05/24 00:00 [received]
PHST- 2017/07/19 00:00 [revised]
PHST- 2017/08/09 00:00 [accepted]
PHST- 2017/08/28 06:00 [pubmed]
PHST- 2018/05/23 06:00 [medline]
PHST- 2017/08/28 06:00 [entrez]
AID - S0006-8993(17)30345-1 [pii]
AID - 10.1016/j.brainres.2017.08.009 [doi]
PST - ppublish
SO  - Brain Res. 2017 Nov 1;1674:55-61. doi: 10.1016/j.brainres.2017.08.009. Epub 2017 
      Aug 24.