PMID- 28844143
OWN - NLM
STAT- MEDLINE
DCOM- 20171113
LR  - 20191210
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 65
IP  - 37
DP  - 2017 Sep 20
TI  - Simultaneous Enantioselective Determination of the Chiral Fungicide 
      Prothioconazole and Its Major Chiral Metabolite Prothioconazole-Desthio in Food 
      and Environmental Samples by Ultraperformance Liquid Chromatography-Tandem Mass 
      Spectrometry.
PG  - 8241-8247
LID - 10.1021/acs.jafc.7b02903 [doi]
AB  - An efficient and sensitive chiral analytical method was established for the 
      determination of the chiral fungicide prothioconazole and its major chiral 
      metabolite prothioconazole-desthio in agricultural and environmental samples 
      using ultraperformance liquid chromatography-tandem mass spectrometry. The 
      optical rotation and absolute configuration of enantiomers were identified by 
      optical rotation detector and electronic circular dichroism spectra. The elution 
      order of prothioconazole and its chiral metabolite enantiomers was 
      R-(+)-prothioconazole-desthio, S-(-)-prothioconazole-desthio, 
      R-(-)-prothioconazole, and S-(+)-prothioconazole. The mean recoveries from the 
      samples was 71.8-102.0% with intraday relative standard deviations (RSDs) of 
      0.3-11.9% and interday RSDs of 0.9-10.6%. The formation of 
      prothioconazole-desthio was studied in soil under field conditions and 
      enantioselective degradation was observed for chiral prothioconazole. Remarkable 
      enantioselective degradation was observed: R-prothioconazole degraded 
      preferentially with EF values from 0.48 to 0.37. Although prothioconazole-desthio 
      is the most remarkably bioactive metabolite, no obvious enantioselective behavior 
      was observed in soil. These results may help to systematically evaluate 
      prothioconazole and its metabolites in food and environmental safety.
FAU - Zhang, Zhaoxian
AU  - Zhang Z
AD  - Department of Pesticide Science, College of Plant Protection, Nanjing 
      Agricultural University, State & Local Joint Engineering Research Center of Green 
      Pesticide Invention and Application , Nanjing 210095, China.
FAU - Zhang, Qing
AU  - Zhang Q
AD  - Department of Pesticide Science, College of Plant Protection, Nanjing 
      Agricultural University, State & Local Joint Engineering Research Center of Green 
      Pesticide Invention and Application , Nanjing 210095, China.
FAU - Gao, Beibei
AU  - Gao B
AD  - Department of Pesticide Science, College of Plant Protection, Nanjing 
      Agricultural University, State & Local Joint Engineering Research Center of Green 
      Pesticide Invention and Application , Nanjing 210095, China.
FAU - Gou, Gaozhang
AU  - Gou G
AD  - College of Science, Honghe University , Mengzi 661199, China.
FAU - Li, Lianshan
AU  - Li L
AD  - Department of Pesticide Science, College of Plant Protection, Nanjing 
      Agricultural University, State & Local Joint Engineering Research Center of Green 
      Pesticide Invention and Application , Nanjing 210095, China.
FAU - Shi, Haiyan
AU  - Shi H
AD  - Department of Pesticide Science, College of Plant Protection, Nanjing 
      Agricultural University, State & Local Joint Engineering Research Center of Green 
      Pesticide Invention and Application , Nanjing 210095, China.
FAU - Wang, Minghua
AU  - Wang M
AUID- ORCID: 0000-0001-5715-4981
AD  - Department of Pesticide Science, College of Plant Protection, Nanjing 
      Agricultural University, State & Local Joint Engineering Research Center of Green 
      Pesticide Invention and Application , Nanjing 210095, China.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20170911
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Fungicides, Industrial)
RN  - 0 (Soil Pollutants)
RN  - 0 (Triazoles)
RN  - 27B9FV58IY (prothioconazole)
SB  - IM
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Cucumis sativus/chemistry
MH  - Food Contamination/*analysis
MH  - Fungicides, Industrial/*chemistry
MH  - Pyrus/chemistry
MH  - Soil Pollutants/*chemistry
MH  - Stereoisomerism
MH  - Tandem Mass Spectrometry/*methods
MH  - Triazoles/*chemistry
OTO - NOTNLM
OT  - UPLC-MS/MS
OT  - absolute configuration
OT  - chiral metabolite
OT  - enantioseparation
OT  - prothioconazole
EDAT- 2017/08/29 06:00
MHDA- 2017/11/14 06:00
CRDT- 2017/08/29 06:00
PHST- 2017/08/29 06:00 [pubmed]
PHST- 2017/11/14 06:00 [medline]
PHST- 2017/08/29 06:00 [entrez]
AID - 10.1021/acs.jafc.7b02903 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2017 Sep 20;65(37):8241-8247. doi: 10.1021/acs.jafc.7b02903. 
      Epub 2017 Sep 11.