PMID- 28845602
OWN - NLM
STAT- MEDLINE
DCOM- 20181105
LR  - 20190201
IS  - 2041-1014 (Electronic)
IS  - 2041-1006 (Print)
IS  - 2041-1006 (Linking)
VI  - 33
IP  - 1
DP  - 2018 Feb
TI  - The function of dendritic cells in modulating the host response.
PG  - 13-21
LID - 10.1111/omi.12195 [doi]
AB  - Dendritic cells (DCs) are antigen-presenting cells that capture, process, and 
      present antigens to lymphocytes to initiate and regulate the adaptive immune 
      response. DCs detect bacteria in skin and mucosa and migrate into regional lymph 
      nodes, where they stimulate antigen-specific T and B lymphocyte activation and 
      proliferation. DCs direct CD4 T cells to differentiate to T-cell subsets such as 
      T helper cells types 1, 2, and 17, and regulatory T cells. The periodontium is 
      chronically exposed to oral bacteria that stimulate an inflammatory response to 
      induce gingivitis or periodontitis. DCs play both protective and destructive 
      roles through activation of the acquired immune response and are also reported to 
      be a source of osteoclast precursors that promote bone resorption. FOXO1, a 
      member of the forkhead box O family of transcription factors, plays a significant 
      role in the activation of DCs. The function of DCs in periodontal inflammation 
      has been investigated in a mouse model by lineage-specific deletion of FOXO1 in 
      these cells. Deletion of FOXO1 reduces DC protective function and enhances 
      susceptibility to periodontitis. The kinase Akt, phosphorylates FOXO1 to inhibit 
      FOXO activity. Hence the Akt-FOXO1 axis may play a key role in regulating DCs to 
      have a significant impact on periodontal disease.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Song, L
AU  - Song L
AD  - Department of Periodontics, School of Dental Medicine, University of 
      Pennsylvania, Philadelphia, PA, USA.
AD  - Department of Stomatology, The Fifth People's Hospital of Shanghai, Fudan 
      University, Shanghai, China.
FAU - Dong, G
AU  - Dong G
AD  - Department of Periodontics, School of Dental Medicine, University of 
      Pennsylvania, Philadelphia, PA, USA.
FAU - Guo, L
AU  - Guo L
AD  - Department of Periodontics, School of Dental Medicine, University of 
      Pennsylvania, Philadelphia, PA, USA.
AD  - Molecular Laboratory for Gene Therapy and Tooth Regeneration and Department of 
      Orthodontics, Beijing Key Laboratory of Tooth Regeneration and Function 
      Reconstruction, Capital Medical University School of Stomatology, Beijing, China.
FAU - Graves, D T
AU  - Graves DT
AUID- ORCID: 0000-0002-4664-8529
AD  - Department of Periodontics, School of Dental Medicine, University of 
      Pennsylvania, Philadelphia, PA, USA.
LA  - eng
GR  - R01 DE017732/DE/NIDCR NIH HHS/United States
GR  - R01 DE019108/DE/NIDCR NIH HHS/United States
GR  - R01 DE021921/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20171009
PL  - Denmark
TA  - Mol Oral Microbiol
JT  - Molecular oral microbiology
JID - 101524770
RN  - 0 (Forkhead Box Protein O1)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxo1 protein, mouse)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.1.137 (Phosphatidylinositol 3-Kinase)
MH  - Adaptive Immunity/*immunology
MH  - Animals
MH  - Bacteria/immunology
MH  - Cell Differentiation/immunology
MH  - Cell Proliferation
MH  - Dendritic Cells/*immunology/*physiology
MH  - Forkhead Box Protein O1/genetics/metabolism
MH  - Forkhead Transcription Factors/immunology
MH  - Gene Deletion
MH  - Gingivitis/immunology
MH  - Host-Pathogen Interactions/*immunology/*physiology
MH  - Inflammation/immunology
MH  - Langerhans Cells/immunology
MH  - Lymph Nodes/immunology
MH  - Lymphocyte Activation
MH  - Lymphocytes/immunology
MH  - Mice
MH  - Mucous Membrane/microbiology
MH  - Osteoclasts/immunology
MH  - Periodontal Diseases/*immunology
MH  - Periodontitis/immunology
MH  - Phosphatidylinositol 3-Kinase/metabolism
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Signal Transduction
MH  - Skin/microbiology
MH  - T-Lymphocytes, Helper-Inducer
PMC - PMC5771978
MID - NIHMS901781
OTO - NOTNLM
OT  - FOXO
OT  - acquired immunity
OT  - forkhead
OT  - gingiva
OT  - gingivitis
OT  - immune response
OT  - lymphocyte
OT  - periodontal disease
OT  - periodontitis
EDAT- 2017/08/29 06:00
MHDA- 2018/11/06 06:00
PMCR- 2019/02/01
CRDT- 2017/08/29 06:00
PHST- 2017/08/22 00:00 [accepted]
PHST- 2017/08/29 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
PHST- 2017/08/29 06:00 [entrez]
PHST- 2019/02/01 00:00 [pmc-release]
AID - 10.1111/omi.12195 [doi]
PST - ppublish
SO  - Mol Oral Microbiol. 2018 Feb;33(1):13-21. doi: 10.1111/omi.12195. Epub 2017 Oct 
      9.