PMID- 28846851
OWN - NLM
STAT- MEDLINE
DCOM- 20180820
LR  - 20211204
IS  - 1205-7541 (Electronic)
IS  - 0008-4212 (Linking)
VI  - 96
IP  - 3
DP  - 2018 Mar
TI  - The regulation of pituitary-thyroid abnormalities by peripheral administration of 
      levothyroxine increased brain-derived neurotrophic factor and reelin protein 
      expression in an animal model of Alzheimer's disease.
PG  - 275-280
LID - 10.1139/cjpp-2016-0434 [doi]
AB  - Alzheimer's disease (AD) is associated with decreased serum levels of thyroid 
      hormones (THs), increased levels of thyroid-stimulating hormone (TSH), and 
      decreased protein expression of brain-derived neurotrophic factor (BDNF) and 
      reelin in the hippocampus. In this study, we have evaluated the effect of 
      subcutaneous administration of levothyroxine (L-T(4)) on levels of THs and TSH as 
      well as protein expression of BDNF and reelin in AD rats. To make an animal model 
      of AD, amyloid-beta peptide (Abeta) plus ibotenic acid were infused 
      intrahippocampally, and rats were treated with L-T(4) and (or) saline for 10 
      days. The levels of THs and TSH were measured by ELISA kits. Protein synthesis 
      was detected by Western blotting method. Results have been shown that serum level 
      of THs, BDNF, and reelin protein expression in the hippocampus were significantly 
      decreased (P < 0.001) in AD animals and elevated significantly in AD rats treated 
      with L-T(4) (P < 0.01). Data showed that TSH level significantly decreased in AD 
      rats treated with L-T(4) (P < 0.05). These findings indicated that L-T(4) 
      increased BDNF and reelin protein expression by regulation of serum THs and TSH 
      level in Abeta-induced AD rats.
FAU - Shabani, Sahreh
AU  - Shabani S
AD  - a Physiology Research Center (PRC), Department of Physiology, School of Medicine, 
      Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
FAU - Farbood, Yaghoob
AU  - Farbood Y
AD  - a Physiology Research Center (PRC), Department of Physiology, School of Medicine, 
      Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
FAU - Mard, Seyyed Ali
AU  - Mard SA
AD  - a Physiology Research Center (PRC), Department of Physiology, School of Medicine, 
      Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
FAU - Sarkaki, Alireza
AU  - Sarkaki A
AD  - a Physiology Research Center (PRC), Department of Physiology, School of Medicine, 
      Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
FAU - Ahangarpour, Akram
AU  - Ahangarpour A
AD  - a Physiology Research Center (PRC), Department of Physiology, School of Medicine, 
      Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
FAU - Khorsandi, Layasadat
AU  - Khorsandi L
AD  - b Cellular & Molecular Research Center, Department of Anatomical Sciences, School 
      of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20170828
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cell Adhesion Molecules, Neuronal)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Reelin Protein)
RN  - 0 (Reln protein, rat)
RN  - 0 (Thyroid Hormones)
RN  - 9002-71-5 (Thyrotropin)
RN  - EC 3.4.21.- (Serine Endopeptidases)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Alzheimer Disease/blood/drug therapy/*metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cell Adhesion Molecules, Neuronal/*metabolism
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Extracellular Matrix Proteins/*metabolism
MH  - Gene Expression Regulation/*drug effects
MH  - Male
MH  - Nerve Tissue Proteins/*metabolism
MH  - Pituitary Gland/*drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Reelin Protein
MH  - Serine Endopeptidases/*metabolism
MH  - Thyroid Gland/*drug effects/metabolism
MH  - Thyroid Hormones/blood
MH  - Thyrotropin/blood
MH  - Thyroxine/administration & dosage/*pharmacology/therapeutic use
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - brain-derived neurotrophic factor
OT  - facteur neurotrophique derive du cerveau
OT  - levothyroxine
OT  - levothyroxine
OT  - maladie d'Alzheimer
OT  - reelin
OT  - reeline
EDAT- 2017/08/29 06:00
MHDA- 2018/08/21 06:00
CRDT- 2017/08/29 06:00
PHST- 2017/08/29 06:00 [pubmed]
PHST- 2018/08/21 06:00 [medline]
PHST- 2017/08/29 06:00 [entrez]
AID - 10.1139/cjpp-2016-0434 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 2018 Mar;96(3):275-280. doi: 10.1139/cjpp-2016-0434. 
      Epub 2017 Aug 28.