PMID- 28847140
OWN - NLM
STAT- MEDLINE
DCOM- 20180313
LR  - 20190402
IS  - 0304-4920 (Print)
IS  - 0304-4920 (Linking)
VI  - 60
IP  - 4
DP  - 2017 Aug 31
TI  - Effects of B Vitamins Overload on Plasma Insulin Level and Hydrogen Peroxide 
      Generation in Rats.
PG  - 207-214
LID - CJP.2017.BAF469 [pii]
LID - 10.4077/CJP.2017.BAF469 [doi]
AB  - It has been reported that nicotinamide-overload induces oxidative stress 
      associated with insulin resistance, the key feature of type 2 diabetes mellitus 
      (T2DM). This study aimed to investigate the effects of B vitamins in T2DM. 
      Glucose tolerance tests were carried out in adult Sprague-Dawley rats treated 
      with or without cumulative doses of B vitamins. More specifically, insulin 
      tolerance tests were also carried out in adult Sprague-Dawley rats treated with 
      or without cumulative doses of Vitamin B3. We found that cumulative Vitamin B1 
      and Vitamin B3 administration significantly increased the plasma H(2)O(2) levels 
      associated with high insulin levels. Only Vitamin B3 reduced muscular and hepatic 
      glycogen contents. Cumulative administration of nicotinic acid, another form of 
      Vitamin B3, also significantly increased plasma insulin level and H(2)O(2) 
      generation. Moreover, cumulative administration of nicotinic acid or nicotinamide 
      impaired glucose metabolism. This study suggested that excess Vitamin B1 and 
      Vitamin B3 caused oxidative stress and insulin resistance.
FAU - Sun, Wuping
AU  - Sun W
AD  - Department of Pain Medicine, The Affiliated Nanshan People's Hospital of Shenzhen 
      University, Shenzhen Municipal Sixth People's Hospital, Shenzhen 518060, People's 
      Republic of China.
FAU - Zhai, Mingzhu
AU  - Zhai M
AD  - Institute of Science and Technology Austria, Am Campus 1, Klosterneuburg 3400, 
      Austria.
FAU - Zhou, Qian
AU  - Zhou Q
AD  - Department of Pain Medicine, The Affiliated Nanshan People's Hospital of Shenzhen 
      University, Shenzhen Municipal Sixth People's Hospital, Shenzhen 518060, People's 
      Republic of China.
FAU - Qian, Chengrui
AU  - Qian C
AD  - Department of Pain Medicine, The Affiliated Nanshan People's Hospital of Shenzhen 
      University, Shenzhen Municipal Sixth People's Hospital, Shenzhen 518060, People's 
      Republic of China.
FAU - Jiang, Changyu
AU  - Jiang C
AD  - Department of Pain Medicine, The Affiliated Nanshan People's Hospital of Shenzhen 
      University, Shenzhen Municipal Sixth People's Hospital, Shenzhen 518060, People's 
      Republic of China.
LA  - eng
GR  - NO. JCYJ20160429182122843, NO. JCYJ20160429181451546/Shenzhen Municipal Science, 
      Technology and Innovation Commission/International
GR  - NO. ZDSYS20140509150415945/Municipal Key Laboratory Program of 
      Shenzhen/International
PT  - Journal Article
PL  - India
TA  - Chin J Physiol
JT  - The Chinese journal of physiology
JID - 7804502
RN  - 0 (Insulin)
RN  - 12001-76-2 (Vitamin B Complex)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Glucose/metabolism
MH  - Hydrogen Peroxide/*metabolism
MH  - Insulin/*blood
MH  - Insulin Resistance
MH  - Male
MH  - Oxidative Stress/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Vitamin B Complex/*toxicity
OTO - NOTNLM
OT  - B vitamins
OT  - insulin resistance
OT  - nicotinamide
OT  - nicotinic acid
OT  - oxidative stress
COIS- All authors have declared no conflicts of interest.
EDAT- 2017/08/30 06:00
MHDA- 2018/03/14 06:00
CRDT- 2017/08/30 06:00
PHST- 2017/08/30 06:00 [pubmed]
PHST- 2018/03/14 06:00 [medline]
PHST- 2017/08/30 06:00 [entrez]
AID - CJP.2017.BAF469 [pii]
AID - 10.4077/CJP.2017.BAF469 [doi]
PST - ppublish
SO  - Chin J Physiol. 2017 Aug 31;60(4):207-214. doi: 10.4077/CJP.2017.BAF469.