PMID- 28847297 OWN - NLM STAT- MEDLINE DCOM- 20190814 LR - 20200225 IS - 1875-6190 (Electronic) IS - 1570-159X (Print) IS - 1570-159X (Linking) VI - 17 IP - 4 DP - 2019 TI - NGF and BDNF Alterations by Prenatal Alcohol Exposure. PG - 308-317 LID - 10.2174/1570159X15666170825101308 [doi] AB - BACKGROUND: It is now widely established that the devastating effects of prenatal alcohol exposure on the embryo and fetus development cause marked cognitive and neurobiological deficits in the newborns. The negative effects of the gestational alcohol use have been well documented and known for some time. However, also the subtle role of alcohol consumption by fathers prior to mating is drawing special attention. OBJECTIVE: Both paternal and maternal alcohol exposure has been shown to affect the neurotrophins' signalling pathways in the brain and in target organs of ethanol intoxication. Neurotrophins, in particular nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), are molecules playing a pivotal role in the survival, development and function of the peripheral and central nervous systems but also in the pathogenesis of developmental defects caused by alcohol exposure. METHODS: New researches from the available literature and experimental data from our laboratory are presented in this review to offer the most recent findings regarding the effects of maternal and paternal prenatal ethanol exposure especially on the neurotrophins' signalling pathways. RESULTS: NGF and BDNF changes play a subtle role in short- and long-lasting effects of alcohol in ethanol target tissues, including neuronal cell death and severe cognitive and physiological deficits in the newborns. CONCLUSION: The review suggests a possible therapeutic intervention based on the use of specific molecules with antioxidant properties in order to induce a potential prevention of the harmful effects of the paternal and/or maternal alcohol exposure. CI - Copyright(c) Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. FAU - Carito, Valentina AU - Carito V AD - Institute of Cell Biology and Neurobiology (IBCN-CNR), Rome, Italy. FAU - Ceccanti, Mauro AU - Ceccanti M AD - Center for Alcohol Abuse (Centro Riferimento Alcologico Regione Lazio-CRARL), Department of Clinical Medicine, Sapienza University of Rome, Italy. FAU - Ferraguti, Giampiero AU - Ferraguti G AD - Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Italy. FAU - Coccurello, Roberto AU - Coccurello R AD - Institute of Cell Biology and Neurobiology (IBCN-CNR), Rome, Italy. FAU - Ciafre, Stefania AU - Ciafre S AD - Institute of Translational Pharmacology, (IFT-CNR), Rome, Italy. FAU - Tirassa, Paola AU - Tirassa P AD - Institute of Cell Biology and Neurobiology (IBCN-CNR), Rome, Italy. FAU - Fiore, Marco AU - Fiore M AD - Institute of Cell Biology and Neurobiology (IBCN-CNR), Rome, Italy. LA - eng PT - Journal Article PT - Review PL - United Arab Emirates TA - Curr Neuropharmacol JT - Current neuropharmacology JID - 101157239 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (NGF protein, human) RN - 3K9958V90M (Ethanol) RN - 7171WSG8A2 (BDNF protein, human) RN - 9061-61-4 (Nerve Growth Factor) MH - Alcohol Drinking/adverse effects/*metabolism MH - Animals MH - Brain/drug effects/pathology MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Ethanol/pharmacology MH - Female MH - Humans MH - Male MH - Maternal Exposure MH - Nerve Growth Factor/*metabolism MH - Paternal Exposure MH - Pregnancy MH - Prenatal Exposure Delayed Effects/*metabolism PMC - PMC6482479 OTO - NOTNLM OT - BDNF OT - FAS OT - FASD OT - Gestational alcohol OT - NGF OT - oxidative stress. EDAT- 2017/08/30 06:00 MHDA- 2019/08/15 06:00 PMCR- 2019/10/01 CRDT- 2017/08/30 06:00 PHST- 2017/06/28 00:00 [received] PHST- 2017/08/02 00:00 [revised] PHST- 2017/08/20 00:00 [accepted] PHST- 2017/08/30 06:00 [pubmed] PHST- 2019/08/15 06:00 [medline] PHST- 2017/08/30 06:00 [entrez] PHST- 2019/10/01 00:00 [pmc-release] AID - CN-EPUB-85463 [pii] AID - CN-17-308 [pii] AID - 10.2174/1570159X15666170825101308 [doi] PST - ppublish SO - Curr Neuropharmacol. 2019;17(4):308-317. doi: 10.2174/1570159X15666170825101308.