PMID- 28847977
OWN - NLM
STAT- MEDLINE
DCOM- 20180621
LR  - 20180621
IS  - 1940-6215 (Electronic)
IS  - 1940-6215 (Linking)
VI  - 10
IP  - 11
DP  - 2017 Nov
TI  - Caloric Restriction Prevents Carcinogen-Initiated Liver Tumorigenesis in Mice.
PG  - 660-670
LID - 10.1158/1940-6207.CAPR-17-0174 [doi]
AB  - Caloric restriction (CR) and endurance exercise elicit wide-ranging health 
      benefits including reduced risk of select cancers. In addition, diet composition 
      influences oncogenesis, although its interactions with exercise and CR are not 
      well understood. Therefore, to investigate the potential interactions between 
      diet and lifestyle interventions on liver tumorigenesis, the carcinogen 
      diethylnitrosamine was administered to 72 male C57Bl/6 mice that were 
      subsequently fed diets enriched with lard (CTL) or olive oil and were further 
      stratified to voluntary wheel running (Ex) or 30% CR for 49 weeks. Although Ex 
      and diet composition did not influence liver oncogenesis, CR prevented hepatic 
      tumor formation. In addition, CR reduced steatosis, hepatocyte ballooning, 
      inflammation, and immune cell infiltration, all of which are hallmarks in the 
      progression of nonalcoholic fatty liver disease to liver tumorigenesis. RNA 
      sequencing of nontransformed liver tissues from CR mice revealed changes in 
      metabolic pathways and reduced inflammation, cytokine production, stellate cell 
      activation and migration, and genes associated with liver injury and oncogenesis. 
      These data demonstrate that CR protects against steatosis, liver inflammation, 
      and liver injury and is a robust deterrent of carcinogen-induced hepatic 
      oncogenesis. Cancer Prev Res; 10(11); 660-70. (c)2017 AACR.
CI  - (c)2017 American Association for Cancer Research.
FAU - Ploeger, Jonathan M
AU  - Ploeger JM
AD  - Department of Food Science and Nutrition, University of Minnesota, Minneapolis, 
      Minnesota.
FAU - Manivel, Juan C
AU  - Manivel JC
AD  - Department of Pathology and Laboratory Medicine. Veterans Administration Medical 
      Center. Minneapolis, Minnesota.
FAU - Boatner, Lauren N
AU  - Boatner LN
AD  - Department of Biochemistry, Molecular Biology, and Biophysics, University of 
      Minnesota, Minneapolis, Minnesota.
FAU - Mashek, Douglas G
AU  - Mashek DG
AD  - Department of Biochemistry, Molecular Biology, and Biophysics, University of 
      Minnesota, Minneapolis, Minnesota. dmashek@umn.edu.
AD  - Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
LA  - eng
PT  - Journal Article
DEP - 20170828
PL  - United States
TA  - Cancer Prev Res (Phila)
JT  - Cancer prevention research (Philadelphia, Pa.)
JID - 101479409
RN  - 0 (Carcinogens)
RN  - 0 (Dietary Fats)
RN  - 0 (Olive Oil)
RN  - 3IQ78TTX1A (Diethylnitrosamine)
RN  - SI6O3IW77Z (lard)
SB  - IM
MH  - Animals
MH  - *Caloric Restriction
MH  - Carcinogenesis/*chemically induced/pathology
MH  - Carcinogens/toxicity
MH  - Chemical and Drug Induced Liver Injury/*diet therapy/etiology/pathology
MH  - Dietary Fats/adverse effects
MH  - Diethylnitrosamine/toxicity
MH  - Hepatitis/*diet therapy/etiology/pathology
MH  - Liver/drug effects/pathology
MH  - Liver Neoplasms, Experimental/chemically induced/*diet therapy/prevention & 
      control
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Non-alcoholic Fatty Liver Disease/chemically induced/*diet therapy/pathology
MH  - Olive Oil/adverse effects
MH  - Physical Conditioning, Animal
EDAT- 2017/08/30 06:00
MHDA- 2018/06/22 06:00
CRDT- 2017/08/30 06:00
PHST- 2017/06/06 00:00 [received]
PHST- 2017/07/27 00:00 [revised]
PHST- 2017/08/22 00:00 [accepted]
PHST- 2017/08/30 06:00 [pubmed]
PHST- 2018/06/22 06:00 [medline]
PHST- 2017/08/30 06:00 [entrez]
AID - 1940-6207.CAPR-17-0174 [pii]
AID - 10.1158/1940-6207.CAPR-17-0174 [doi]
PST - ppublish
SO  - Cancer Prev Res (Phila). 2017 Nov;10(11):660-670. doi: 
      10.1158/1940-6207.CAPR-17-0174. Epub 2017 Aug 28.