PMID- 28848385
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1662-5099 (Print)
IS  - 1662-5099 (Electronic)
IS  - 1662-5099 (Linking)
VI  - 10
DP  - 2017
TI  - Translational Identification of Transcriptional Signatures of Major Depression 
      and Antidepressant Response.
PG  - 248
LID - 10.3389/fnmol.2017.00248 [doi]
LID - 248
AB  - Major depressive disorder (MDD) is a highly prevalent mental illness whose 
      therapy management remains uncertain, with more than 20% of patients who do not 
      achieve response to antidepressants. Therefore, identification of reliable 
      biomarkers to predict response to treatment will greatly improve MDD patient 
      medical care. Due to the inaccessibility and lack of brain tissues from living 
      MDD patients to study depression, researches using animal models have been useful 
      in improving sensitivity and specificity of identifying biomarkers. In the 
      current study, we used the unpredictable chronic mild stress (UCMS) model and 
      correlated stress-induced depressive-like behavior (n = 8 unstressed vs. 8 
      stressed mice) as well as the fluoxetine-induced recovery (n = 8 stressed and 
      fluoxetine-treated mice vs. 8 unstressed and fluoxetine-treated mice) with 
      transcriptional signatures obtained by genome-wide microarray profiling from 
      whole blood, dentate gyrus (DG), and the anterior cingulate cortex (ACC). 
      Hierarchical clustering and rank-rank hypergeometric overlap (RRHO) procedures 
      allowed us to identify gene transcripts with variations that correlate with 
      behavioral profiles. As a translational validation, some of those transcripts 
      were assayed by RT-qPCR with blood samples from 10 severe major depressive 
      episode (MDE) patients and 10 healthy controls over the course of 30 weeks and 
      four visits. Repeated-measures ANOVAs revealed candidate trait biomarkers 
      (ARHGEF1, CMAS, IGHMBP2, PABPN1 and TBC1D10C), whereas univariate linear 
      regression analyses uncovered candidates state biomarkers (CENPO, FUS and NUBP1), 
      as well as prediction biomarkers predictive of antidepressant response (CENPO, 
      NUBP1). These data suggest that such a translational approach may offer new leads 
      for clinically valid panels of biomarkers for MDD.
FAU - Herve, Mylene
AU  - Herve M
AD  - Aix Marseille Univ, CNRS, CRN2M UMR 7286Marseille, France.
AD  - FondaMental, Fondation de Recherche et de Soins en Sante MentaleCreteil, France.
FAU - Bergon, Aurelie
AU  - Bergon A
AD  - Aix Marseille Univ, INSERM, TAGC UMR_S 1090Marseille, France.
FAU - Le Guisquet, Anne-Marie
AU  - Le Guisquet AM
AD  - INSERM U930 Eq 4, UFR Sciences et Techniques, Universite Francois RabelaisTours, 
      France.
FAU - Leman, Samuel
AU  - Leman S
AD  - INSERM U930 Eq 4, UFR Sciences et Techniques, Universite Francois RabelaisTours, 
      France.
FAU - Consoloni, Julia-Lou
AU  - Consoloni JL
AD  - Aix Marseille Univ, CNRS, CRN2M UMR 7286Marseille, France.
AD  - FondaMental, Fondation de Recherche et de Soins en Sante MentaleCreteil, France.
AD  - AP-HM, Hopital Sainte Marguerite, Pole de Psychiatrie Universitaire 
      SolarisMarseille, France.
FAU - Fernandez-Nunez, Nicolas
AU  - Fernandez-Nunez N
AD  - TGML, Platform IbiSA, Aix Marseille Univ, INSERM U1090, TAGCMarseille, France.
FAU - Lefebvre, Marie-Noelle
AU  - Lefebvre MN
AD  - CIC-CPCET, AP-HM, Hopital La TimoneMarseille, France.
FAU - El-Hage, Wissam
AU  - El-Hage W
AD  - INSERM U930 Eq 4, UFR Sciences et Techniques, Universite Francois RabelaisTours, 
      France.
AD  - CHRU de Tours, Clinique Psychiatrique UniversitaireTours, France.
AD  - INSERM CIC 1415, Centre d'Investigation Clinique, CHRU de ToursTours, France.
FAU - Belzeaux, Raoul
AU  - Belzeaux R
AD  - Aix Marseille Univ, CNRS, CRN2M UMR 7286Marseille, France.
AD  - FondaMental, Fondation de Recherche et de Soins en Sante MentaleCreteil, France.
AD  - AP-HM, Hopital Sainte Marguerite, Pole de Psychiatrie Universitaire 
      SolarisMarseille, France.
AD  - McGill Group for Suicide Studies, Douglas Mental Health University Institute, 
      Department of Psychiatry, McGill UniversityMontreal, QC, Canada.
FAU - Belzung, Catherine
AU  - Belzung C
AD  - INSERM U930 Eq 4, UFR Sciences et Techniques, Universite Francois RabelaisTours, 
      France.
FAU - Ibrahim, El Cherif
AU  - Ibrahim EC
AD  - Aix Marseille Univ, CNRS, CRN2M UMR 7286Marseille, France.
AD  - FondaMental, Fondation de Recherche et de Soins en Sante MentaleCreteil, France.
AD  - Aix Marseille Univ, CNRS, INT, Inst Neurosci Timone UMR 7289Marseille, France.
LA  - eng
PT  - Journal Article
DEP - 20170808
PL  - Switzerland
TA  - Front Mol Neurosci
JT  - Frontiers in molecular neuroscience
JID - 101477914
PMC - PMC5550836
OTO - NOTNLM
OT  - antidepressant
OT  - biomarker
OT  - blood
OT  - chronic stress
OT  - depression
OT  - mRNA
OT  - transcriptomics
EDAT- 2017/08/30 06:00
MHDA- 2017/08/30 06:01
PMCR- 2017/01/01
CRDT- 2017/08/30 06:00
PHST- 2017/06/16 00:00 [received]
PHST- 2017/07/24 00:00 [accepted]
PHST- 2017/08/30 06:00 [entrez]
PHST- 2017/08/30 06:00 [pubmed]
PHST- 2017/08/30 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fnmol.2017.00248 [doi]
PST - epublish
SO  - Front Mol Neurosci. 2017 Aug 8;10:248. doi: 10.3389/fnmol.2017.00248. eCollection 
      2017.