PMID- 28848612
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1726-913X (Print)
IS  - 1726-9148 (Electronic)
IS  - 1726-913X (Linking)
VI  - 15
IP  - 2
DP  - 2017 Apr
TI  - Relationship of Serum Apolipoprotein A-V Levels, Oxidative Stress and 
      Inflammatory Biomarkers with Hypertriglyceridemia in Type 2 Diabetes Mellitus.
PG  - e44805
LID - 10.5812/ijem.44805 [doi]
LID - e44805
AB  - BACKGROUND: Serum levels of triglycerides (TGs) are often found to be raised in 
      type 2 diabetes mellitus (T2DM). TG levels >/= 2.2 mM, systemic inflammation and 
      oxidative stress (OS) are known to increase the risk of incident cardiovascular 
      disease (CVD) substantially. In recent years, apolipoprotein A-V (Apo A-V 
      protein) has attracted considerably as a modulator of circulating TG levels. 
      OBJECTIVES: The study was conducted in order to evaluate the levels of Apo A - V 
      proteins and markers of inflammation and OS in patients of T2DM with and without 
      hypertriglyceridemia (HTG) and also to assess correlation between them. METHODS: 
      T2DM patients were categorized into two groups of 40 participants, according to 
      criteria for risk of CVD: group 1/ controls (TG </= 1.65 mM, n = 40) and group 2/ 
      cases (TG >/= 2.2 mM, n = 40). Despite the routine investigations, serum levels of 
      Apo A-V, interleukin-6 (IL-6) and Insulin were estimated using ELISA, free fatty 
      acids (FFA) with fluorometric assay and malondialdehyde (MDA) was measured using 
      a spectrophotometer. Comparison of levels and correlation between variables was 
      carried out with appropriate statistical tools. RESULTS: Serum Apo A-V protein 
      levels were found significantly lower (P = 0.04) and MDA was significantly higher 
      (P = 0.049) in cases. MDA correlated with TG levels positively (P = 0.000) and 
      negatively with high density lipoproteins (HDL) (P = 0.000). However Apo A-V 
      protein levels did not correlate with TG levels (P = 0.819, r = -0.027), IL-6 (r 
      = 0.135, P = 0.269), FFA (r = 0.128, P = 0.277) and MDA (r = -0.217, P = 0.073). 
      IL-6 levels significantly and positively correlated with HOMA-IR (r = 0.327, P = 
      0.004) in the all patients. CONCLUSIONS: In patients of T2DM, low levels of Apo 
      A-V are associated with HTG, indicating that Apo A-V is linked with TG 
      metabolism. Burden of oxidative stress is greater in HTG of T2DM as is evident 
      from MDA levels and its correlation with TG levels. Since oxidative stress is an 
      important patho-physiological basis which increases the risk of CVD in patients 
      of T2DM with HTG. Further studies are required in order to explore the possible 
      role of Apo A-V in TG metabolism in diabetes.
FAU - Sharma, Devesh
AU  - Sharma D
AD  - Departement of Biochemistry, University College of Medical Sciences and GTB 
      Hospital, University of Delhi, Delhi, India.
FAU - Garg, Seema
AU  - Garg S
AD  - Departement of Biochemistry, University College of Medical Sciences and GTB 
      Hospital, University of Delhi, Delhi, India.
FAU - Mehndiratta, Mohit
AU  - Mehndiratta M
AD  - Departement of Biochemistry, University College of Medical Sciences and GTB 
      Hospital, University of Delhi, Delhi, India.
FAU - V Madhu, S
AU  - V Madhu S
AD  - Department of Medicine, University College of Medical Sciences and GTB Hospital, 
      University of Delhi, Delhi, India.
FAU - Puri, Dinesh
AU  - Puri D
AD  - Departement of Biochemistry, University College of Medical Sciences and GTB 
      Hospital, University of Delhi, Delhi, India.
LA  - eng
PT  - Journal Article
DEP - 20170422
PL  - Netherlands
TA  - Int J Endocrinol Metab
JT  - International journal of endocrinology and metabolism
JID - 101235597
PMC - PMC5556325
OTO - NOTNLM
OT  - Apolipoprotein A5
OT  - Hypertriglyceridemia
OT  - Inflammation
OT  - Oxidative Stress
OT  - Type 2 Diabetes
EDAT- 2017/08/30 06:00
MHDA- 2017/08/30 06:01
PMCR- 2017/04/01
CRDT- 2017/08/30 06:00
PHST- 2016/12/15 00:00 [received]
PHST- 2017/02/28 00:00 [revised]
PHST- 2017/04/08 00:00 [accepted]
PHST- 2017/08/30 06:00 [entrez]
PHST- 2017/08/30 06:00 [pubmed]
PHST- 2017/08/30 06:01 [medline]
PHST- 2017/04/01 00:00 [pmc-release]
AID - 10.5812/ijem.44805 [doi]
PST - epublish
SO  - Int J Endocrinol Metab. 2017 Apr 22;15(2):e44805. doi: 10.5812/ijem.44805. 
      eCollection 2017 Apr.