PMID- 28848636
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220317
IS  - 2008-5842 (Print)
IS  - 2008-5842 (Electronic)
IS  - 2008-5842 (Linking)
VI  - 9
IP  - 6
DP  - 2017 Jun
TI  - Gastrointestinal symptoms associated with gastroesophageal reflux disease, and 
      their relapses after treatment with proton pump inhibitors: A systematic review.
PG  - 4597-4605
LID - 10.19082/4597 [doi]
AB  - Gastroesophageal reflux disease (GERD) is a common functional gastrointestinal 
      disorder with significant effects on the quality of life. The burden of GERD is 
      soaring in Asia. Preventing symptom relapse is a therapeutic goal in GERD 
      patients. Since proton pump inhibitors (PPI) are the first-line treatment of 
      GERD, drug failure has become a major problem in the treatment procedure. We 
      reviewed the literature in order to find articles related to comorbidities and 
      symptoms affecting GERD from 1980 to 2015 via PubMed and Google Scholar using 
      keywords such as 'Gastroesophageal reflux disease', 'Gastrointestinal symptoms' 
      and Boolean operators (such as AND, OR, NOT). Due to the cost of PPI therapy and 
      the high rate of GERD relapse after PPI therapy, demand for continuing this type 
      of treatment is decreasing. Thus, we need to discover new approaches to treat the 
      disease and also investigate the relationship between the treatment of GERD and 
      its comorbidities and symptoms such as functional constipation.
FAU - Hosseini, Mousalreza
AU  - Hosseini M
AD  - M.D., Gastroenterologist, Assistant Professor, Ghaem Hospital, Faculty of 
      Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Salari, Roshanak
AU  - Salari R
AD  - Ph.D. of Drug Control, Assistant Professor, Department of Traditional Persian 
      Pharmacy, School of Persian and Complementary Medicine, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
FAU - Shariatmaghani, Somayeh
AU  - Shariatmaghani S
AD  - M.D., Internist, Assistant Professor, Ghaem Hospital, Faculty of Medicine, 
      Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Birjandi, Batul
AU  - Birjandi B
AD  - M.D., Internist, School of Medicine, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Salari, Masoumeh
AU  - Salari M
AD  - M.D., Internist, Assistant Professor, Ghaem Hospital, Faculty of Medicine, 
      Mashhad University of Medical Sciences, Mashhad, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170625
PL  - Iran
TA  - Electron Physician
JT  - Electronic physician
JID - 101645099
PMC - PMC5557141
OTO - NOTNLM
OT  - Comorbidities
OT  - Gastroesophageal reflux disease (GERD)
OT  - Proton pump inhibitors (PPI)
OT  - Relapse
COIS- Conflict of Interest: There is no conflict of interest to be declared.
EDAT- 2017/08/30 06:00
MHDA- 2017/08/30 06:01
PMCR- 2017/06/25
CRDT- 2017/08/30 06:00
PHST- 2016/09/10 00:00 [received]
PHST- 2017/01/25 00:00 [accepted]
PHST- 2017/08/30 06:00 [entrez]
PHST- 2017/08/30 06:00 [pubmed]
PHST- 2017/08/30 06:01 [medline]
PHST- 2017/06/25 00:00 [pmc-release]
AID - epj-09-4597 [pii]
AID - 10.19082/4597 [doi]
PST - epublish
SO  - Electron Physician. 2017 Jun 25;9(6):4597-4605. doi: 10.19082/4597. eCollection 
      2017 Jun.