PMID- 28848957
OWN - NLM
STAT- MEDLINE
DCOM- 20180223
LR  - 20181202
IS  - 2050-7895 (Electronic)
IS  - 2050-7887 (Linking)
VI  - 19
IP  - 10
DP  - 2017 Oct 18
TI  - Epoxide formation from heterogeneous oxidation of benzo[a]pyrene with gas-phase 
      ozone and indoor air.
PG  - 1292-1299
LID - 10.1039/c7em00181a [doi]
AB  - The formation of two classes of epoxide products from the heterogeneous reaction 
      of benzo[a]pyrene (BaP) with gas-phase ozone was demonstrated. BaP was coated on 
      a Pyrex glass tube and oxidized with different concentrations of ozone. After 
      oxidation, the epoxide products were derivatized by N-acetylcystein (NAC) and 
      then analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The 
      results show that in addition to mono-epoxides, diol-epoxides were also formed. 
      BaP exposed to genuine indoor air also produces mono- and diol-epoxides, having 
      similar chromatograms to those produced by oxidation of BaP by low concentrations 
      of ozone. Although it is well recognized that diol-epoxides are formed from BaP 
      oxidation in the human body and that they exhibit carcinogenicity via formation 
      of adducts with DNA, this is the first demonstration that such classes of 
      compounds can be formed by abiotic heterogeneous oxidation.
FAU - Zhou, Shouming
AU  - Zhou S
AD  - Department of Chemistry, University of Toronto, 80 St. George St., Toronto, ON 
      M5S 3H6, Canada. szhou@chem.utoronto.ca leo.yeung@oru.se.
FAU - Yeung, Leo W Y
AU  - Yeung LWY
FAU - Forbes, Matthew W
AU  - Forbes MW
FAU - Mabury, Scott
AU  - Mabury S
FAU - Abbatt, Jonathan P D
AU  - Abbatt JPD
LA  - eng
PT  - Journal Article
PL  - England
TA  - Environ Sci Process Impacts
JT  - Environmental science. Processes & impacts
JID - 101601576
RN  - 0 (DNA Adducts)
RN  - 0 (Epoxy Compounds)
RN  - 3417WMA06D (Benzo(a)pyrene)
RN  - 66H7ZZK23N (Ozone)
SB  - IM
MH  - Air Pollution, Indoor/*analysis
MH  - Animals
MH  - Benzo(a)pyrene/*chemistry
MH  - Chromatography, High Pressure Liquid
MH  - DNA Adducts/analysis
MH  - Epoxy Compounds/*analysis
MH  - Humans
MH  - *Models, Theoretical
MH  - Molecular Structure
MH  - Oxidation-Reduction
MH  - Ozone/*chemistry
MH  - Tandem Mass Spectrometry
EDAT- 2017/08/30 06:00
MHDA- 2018/02/24 06:00
CRDT- 2017/08/30 06:00
PHST- 2017/08/30 06:00 [pubmed]
PHST- 2018/02/24 06:00 [medline]
PHST- 2017/08/30 06:00 [entrez]
AID - 10.1039/c7em00181a [doi]
PST - ppublish
SO  - Environ Sci Process Impacts. 2017 Oct 18;19(10):1292-1299. doi: 
      10.1039/c7em00181a.