PMID- 28849137
OWN - NLM
STAT- MEDLINE
DCOM- 20180515
LR  - 20181113
IS  - 1791-244X (Electronic)
IS  - 1107-3756 (Print)
IS  - 1107-3756 (Linking)
VI  - 40
IP  - 4
DP  - 2017 Oct
TI  - Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine 
      production in human SZ95 sebocytes.
PG  - 1029-1036
LID - 10.3892/ijmm.2017.3109 [doi]
AB  - A large body of evidence indicates that particulate matter (PM)2.5 is associated 
      with various negative effects on human health. However, the impact and molecular 
      mechanism of PM2.5 on the skin have not been elucidated. Therefore, the present 
      study aimed to investigate the effects of two types of PM2.5 [water-soluble 
      extracts (W-PM2.5) and non-water-soluble extracts (NW-PM2.5)] on cell 
      proliferation, cell cycle progression, lipid synthesis, and inflammatory cytokine 
      production of human SZ95 sebocytes. The results demonstrated that NW-PM2.5 and 
      W-PM2.5 exposure dose-dependently inhibited SZ95 sebocyte proliferation by 
      inducing G1 cell arrest. Furthermore, NW-PM2.5 and W-PM2.5 significantly reduced 
      sebaceous lipid synthesis and markedly promoted the production of inflammatory 
      cytokines, including interleukin-1alpha (IL-1alpha), IL-6 and IL-8 in SZ95 sebocytes. 
      Additionally, the expression of aryl hydrocarbon (Ah) receptor (AhR), AhR nuclear 
      translocator protein (ARNT), as well as cytochrome P450 1A1 were significantly 
      increased following PM2.5 exposure. Thus, these findings indicate that PM2.5 
      exerts inhibitory effects on cell proliferation and lipid synthesis, and 
      stimulatory effects on inflammatory cytokine production and AhR signaling 
      activation in human SZ95 sebocytes.
FAU - Liu, Qin
AU  - Liu Q
AD  - Department of Dermatology, Renmin Hospital of Wuhan University, Wuchang, Wuhan, 
      Hubei 430060, P.R. China.
FAU - Wu, Jianbo
AU  - Wu J
AD  - Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuchang, Wuhan, 
      Hubei 430071, P.R. China.
FAU - Song, Jiquan
AU  - Song J
AD  - Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuchang, Wuhan, 
      Hubei 430071, P.R. China.
FAU - Liang, Pin
AU  - Liang P
AD  - Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuchang, Wuhan, 
      Hubei 430071, P.R. China.
FAU - Zheng, Kaiping
AU  - Zheng K
AD  - Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuchang, Wuhan, 
      Hubei 430071, P.R. China.
FAU - Xiao, Guifeng
AU  - Xiao G
AD  - Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuchang, Wuhan, 
      Hubei 430071, P.R. China.
FAU - Liu, Lanting
AU  - Liu L
AD  - Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuchang, Wuhan, 
      Hubei 430071, P.R. China.
FAU - Zouboulis, Christos C
AU  - Zouboulis CC
AD  - Department of Dermatology, Venereology, Allergology and Immunology, Dessau 
      Medical Center, Theodore Fontane Medical University of Brandenburg, Dessau 
      D-06847, Germany.
FAU - Lei, Tiechi
AU  - Lei T
AD  - Department of Dermatology, Renmin Hospital of Wuhan University, Wuchang, Wuhan, 
      Hubei 430060, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170825
PL  - Greece
TA  - Int J Mol Med
JT  - International journal of molecular medicine
JID - 9810955
RN  - 0 (AHR protein, human)
RN  - 0 (ARNT protein, human)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Complex Mixtures)
RN  - 0 (IL1A protein, human)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-1alpha)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Particulate Matter)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - 138391-32-9 (Aryl Hydrocarbon Receptor Nuclear Translocator)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
SB  - IM
MH  - Aryl Hydrocarbon Receptor Nuclear Translocator/agonists/genetics/metabolism
MH  - Basic Helix-Loop-Helix Transcription Factors/agonists/genetics/metabolism
MH  - Cell Line, Transformed
MH  - Cell Proliferation/drug effects
MH  - Complex Mixtures/pharmacology
MH  - Cytochrome P-450 CYP1A1/genetics/metabolism
MH  - Epithelial Cells/cytology/*drug effects/metabolism
MH  - G1 Phase Cell Cycle Checkpoints/*drug effects/genetics
MH  - Gene Expression Regulation
MH  - Humans
MH  - Interleukin-1alpha/*genetics/metabolism
MH  - Interleukin-6/*genetics/metabolism
MH  - Interleukin-8/*genetics/metabolism
MH  - Lipid Metabolism/drug effects
MH  - Particulate Matter/*pharmacology
MH  - Receptors, Aryl Hydrocarbon/agonists/genetics/metabolism
MH  - Sebaceous Glands/cytology/drug effects/metabolism
MH  - Signal Transduction
PMC - PMC5593471
EDAT- 2017/08/30 06:00
MHDA- 2018/05/16 06:00
PMCR- 2017/08/25
CRDT- 2017/08/30 06:00
PHST- 2017/05/15 00:00 [received]
PHST- 2017/08/21 00:00 [accepted]
PHST- 2017/08/30 06:00 [pubmed]
PHST- 2018/05/16 06:00 [medline]
PHST- 2017/08/30 06:00 [entrez]
PHST- 2017/08/25 00:00 [pmc-release]
AID - ijmm-40-04-1029 [pii]
AID - 10.3892/ijmm.2017.3109 [doi]
PST - ppublish
SO  - Int J Mol Med. 2017 Oct;40(4):1029-1036. doi: 10.3892/ijmm.2017.3109. Epub 2017 
      Aug 25.