PMID- 28849547
OWN - NLM
STAT- MEDLINE
DCOM- 20180808
LR  - 20181211
IS  - 1568-5608 (Electronic)
IS  - 0925-4692 (Linking)
VI  - 26
IP  - 1
DP  - 2018 Feb
TI  - Antihyperalgesic effects of ashwagandha (Withania somnifera root extract) in rat 
      models of postoperative and neuropathic pain.
PG  - 207-215
LID - 10.1007/s10787-017-0389-1 [doi]
AB  - The root of Withania somnifera, commonly known as ashwagandha, is a traditional 
      herb in the Indian Ayurvedic system of medicine and is used as a tonic. Here, we 
      investigated whether W. somnifera root extract exhibits analgesic effects in 
      plantar incision (PI) and spared nerve injury (SNI) rat models. Mechanical 
      withdrawal threshold (MWT) was measured by von Frey filaments, and pain-related 
      behavior was determined after operation by ultrasonic vocalization (USV) 
      measurements. Indeed, we examined interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) 
      levels in the isolated dorsal root ganglia (DRG) following SNI in rats using an 
      ELISA cytokine assay. MWT significantly increased 6 and 24 h after PI in rats 
      receiving W. somnifera root extracts (100 and 300 mg/kg). Furthermore, the number 
      of 22-27-kHz USV, which are a distress response, was significantly reduced at 6 
      and 24 h after PI in W. somnifera-treated rats (100 and 300 mg/kg). SNI-induced 
      hyperalgesia and cytokine levels were significantly alleviated after treating 
      with W. somnifera root extracts (100 and 300 mg/kg) for 15 continuous days. The 
      main active compound, withaferin A, from the W. somnifera root extract has shown 
      the CC chemokine family Receptor 2 (CCR2) antagonistic effects on monocyte 
      chemoattractant protein-1 (MCP-1)-induced Ca(2+) response in CCR2 stable cell 
      line. These results indicate that W. somnifera root extract has a potential 
      analgesic effect in rat models for both postoperative and neuropathic pain and 
      shows potential as a drug or supplement for the treatment of pain.
FAU - Lim, Dong Wook
AU  - Lim DW
AD  - Research Group of Innovative Special Food, Korea Food Research Institute, 62, 
      Anyangpangyo-ro, Bundang-gu, Seongnam, 13539, Republic of Korea.
FAU - Kim, Jae Goo
AU  - Kim JG
AD  - Research Group of Innovative Special Food, Korea Food Research Institute, 62, 
      Anyangpangyo-ro, Bundang-gu, Seongnam, 13539, Republic of Korea.
FAU - Lim, Eun Yeong
AU  - Lim EY
AD  - Research Group of Innovative Special Food, Korea Food Research Institute, 62, 
      Anyangpangyo-ro, Bundang-gu, Seongnam, 13539, Republic of Korea.
AD  - Department of Food Biotechnology, Korea University of Science and Technology, 217 
      Gajeong-ro, Yuseong-gu, Daejeon, 34113, Republic of Korea.
FAU - Kim, Yun Tai
AU  - Kim YT
AD  - Research Group of Innovative Special Food, Korea Food Research Institute, 62, 
      Anyangpangyo-ro, Bundang-gu, Seongnam, 13539, Republic of Korea. 
      ytkim@kfri.re.kr.
AD  - Department of Food Biotechnology, Korea University of Science and Technology, 217 
      Gajeong-ro, Yuseong-gu, Daejeon, 34113, Republic of Korea. ytkim@kfri.re.kr.
LA  - eng
GR  - E0164502-02/Korea Food Research Institute/
PT  - Journal Article
DEP - 20170828
PL  - Switzerland
TA  - Inflammopharmacology
JT  - Inflammopharmacology
JID - 9112626
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
RN  - 0 (Withanolides)
RN  - L6DO3QW4K5 (withaferin A)
RN  - V038D626IF (Ashwagandha)
SB  - IM
MH  - Animals
MH  - Cytokines/metabolism
MH  - Hyperalgesia/*drug therapy/metabolism
MH  - Male
MH  - Neuralgia/*drug therapy/metabolism
MH  - Plant Extracts/*pharmacology
MH  - Plant Roots/*chemistry
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Withania/*chemistry
MH  - Withanolides/pharmacology
OTO - NOTNLM
OT  - Analgesic effects
OT  - Ashwagandha
OT  - CCR2
OT  - Pain
OT  - Withaferin A
OT  - Withania somnifera root
EDAT- 2017/08/30 06:00
MHDA- 2018/08/09 06:00
CRDT- 2017/08/30 06:00
PHST- 2017/04/28 00:00 [received]
PHST- 2017/08/11 00:00 [accepted]
PHST- 2017/08/30 06:00 [pubmed]
PHST- 2018/08/09 06:00 [medline]
PHST- 2017/08/30 06:00 [entrez]
AID - 10.1007/s10787-017-0389-1 [pii]
AID - 10.1007/s10787-017-0389-1 [doi]
PST - ppublish
SO  - Inflammopharmacology. 2018 Feb;26(1):207-215. doi: 10.1007/s10787-017-0389-1. 
      Epub 2017 Aug 28.