PMID- 28849601
OWN - NLM
STAT- MEDLINE
DCOM- 20171122
LR  - 20211204
IS  - 1099-0844 (Electronic)
IS  - 0263-6484 (Linking)
VI  - 35
IP  - 7
DP  - 2017 Oct
TI  - Effect of orthodontic force on the expression of PI3K, Akt, and P70S6 K in the 
      human periodontal ligament during orthodontic loading.
PG  - 372-377
LID - 10.1002/cbf.3284 [doi]
AB  - The mammalian target of rapamycin (mTOR) is an atypical serine/threonine protein 
      kinases involved in the regulation of cell growth, proliferation, and 
      differentiation through the PI3K/Akt/mTOR/P70S6 K signalling pathway. P70S6 K as 
      a downstream molecule of mTOR is activated by phosphorylation and subsequently 
      promotes the synthesis of ribosomal and translational proteins. In this study, we 
      investigated the role of PI3K, Akt, and P70S6 K in human periodontal tissue 
      remodelling during orthodontic loading. The prepared tissue specimens taken from 
      4 extracted premolars were processed for immunolabelling. The changes in the 
      expression of PI3K, Akt, and P70S6 K in the periodontal tissues were detected by 
      real-time quantitative-polymerase chain reaction and Western blot analysis. The 
      results from real-time quantitative-polymerase chain reaction and Western blot 
      both showed that the expression of PI3K, Akt, and P70S6 K in the experimental 
      group began to increase at 3 days and increased significantly at 10 days, then 
      decreased approaching the control group level at 28 days. Our findings showed 
      that the expression of PI3K, Akt, and P70S6 K in human periodontal ligament 
      demonstrated a variability during the orthodontic loading, which suggested that 
      the PI3K/Akt/mTOR/P70S6 K signal pathway was involved in orthodontic tooth 
      movement and played a role in the process of periodontium remodelling.
CI  - Copyright (c) 2017 John Wiley & Sons, Ltd.
FAU - Xu, Yunhe
AU  - Xu Y
AD  - Department of Orthodontics, School of Stomatology, China Medical University, 
      Shenyang, Liaoning, People's Republic of China.
FAU - Shen, Jiayuan
AU  - Shen J
AD  - Department of Orthodontics, School of Stomatology, China Medical University, 
      Shenyang, Liaoning, People's Republic of China.
FAU - Muhammed, Fenik Kaml
AU  - Muhammed FK
AD  - Department of Orthodontics, School of Stomatology, China Medical University, 
      Shenyang, Liaoning, People's Republic of China.
FAU - Zheng, Bowen
AU  - Zheng B
AD  - Department of Orthodontics, School of Stomatology, China Medical University, 
      Shenyang, Liaoning, People's Republic of China.
FAU - Zhang, Yuejiao
AU  - Zhang Y
AD  - Department of Orthodontics, School of Stomatology, China Medical University, 
      Shenyang, Liaoning, People's Republic of China.
FAU - Liu, Yi
AU  - Liu Y
AUID- ORCID: 0000-0002-4640-3396
AD  - Department of Orthodontics, School of Stomatology, China Medical University, 
      Shenyang, Liaoning, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20170828
PL  - England
TA  - Cell Biochem Funct
JT  - Cell biochemistry and function
JID - 8305874
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Adolescent
MH  - Cell Proliferation
MH  - Female
MH  - Humans
MH  - Male
MH  - Periodontal Ligament/cytology/*metabolism
MH  - Phosphatidylinositol 3-Kinases/genetics/*metabolism
MH  - Proto-Oncogene Proteins c-akt/genetics/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Ribosomal Protein S6 Kinases, 70-kDa/genetics/*metabolism
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/genetics/metabolism
MH  - *Tooth Movement Techniques
MH  - Young Adult
OTO - NOTNLM
OT  - Akt
OT  - P70S6 K
OT  - PI3K
OT  - mTOR
OT  - orthodontic force
EDAT- 2017/08/30 06:00
MHDA- 2017/11/29 06:00
CRDT- 2017/08/30 06:00
PHST- 2017/02/15 00:00 [received]
PHST- 2017/04/10 00:00 [revised]
PHST- 2017/07/07 00:00 [accepted]
PHST- 2017/08/30 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2017/08/30 06:00 [entrez]
AID - 10.1002/cbf.3284 [doi]
PST - ppublish
SO  - Cell Biochem Funct. 2017 Oct;35(7):372-377. doi: 10.1002/cbf.3284. Epub 2017 Aug 
      28.