PMID- 28850017
OWN - NLM
STAT- MEDLINE
DCOM- 20171116
LR  - 20181125
IS  - 1528-7394 (Print)
IS  - 0098-4108 (Linking)
VI  - 80
IP  - 19-21
DP  - 2017
TI  - Methylmercury exposure for 14 days (short-term) produces behavioral and 
      biochemical changes in mouse cerebellum, liver, and serum.
PG  - 1145-1155
LID - 10.1080/15287394.2017.1357324 [doi]
AB  - Various studies on methylmercury (MeHg)-induced toxicity focused on the central 
      nervous system (CNS) as a primary target. However, MeHg-mediated toxicity is 
      related to metallic interaction with electrophilic groups, which are not solely 
      restricted to the CNS, but these reactive groups are present ubiquitously in 
      several systems/organs. The aim of this study was thus to examine MeHg-induced 
      systemic toxicity in mice using a standardized neurotoxicology testing exposure 
      model to measure cerebellar neurotoxicity by determining biochemical and 
      behavioral parameters in the cerebellum. After 2 weeks exposure to MeHg (40 
      microg/ml; diluted in drinking water; ad libitum), adult male Swiss mice showed a 
      marked motor impairment characteristic of cerebellar toxicity as noted in the 
      following tests: rotarod, beam walking, pole, and hind limb clasping. MeHg 
      treatment resulted in Hg deposition in the cerebellum as well as reduction in 
      cerebellar weight, glutathione peroxidase (GPx) activity, and interleukin (IL)-6 
      levels. MeHg ingestion increased cerebellar glutathione reductase (GR) activity 
      and brain-derived neurotrophic factor (BDNF) levels. In addition to cerebellar 
      toxicity, MeHg treatment also elevated total and non-high density lipoprotein 
      (non-HDL) cholesterol levels, as well as serum aspartate transaminase (AST) and 
      alanine transaminase (ALT) enzymatic activities, systemic parameters. Increased 
      liver weight and reduced serum urea levels were also noted in MeHg-exposed mice. 
      Taken together, our findings demonstrated that a well-standardized exposure 
      protocol to examine MeHg-induced neurotoxicity also produced systemic toxicity in 
      mice, which was characterized by changes in markers of hepatic function as well 
      as serum lipid homeostasis.
FAU - Macedo-Junior, Sergio Jose
AU  - Macedo-Junior SJ
AD  - a Programa de Pos-Graduacao em Farmacologia, Departamento de Farmacologia , 
      Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina , 
      Florianopolis , SC , Brazil.
FAU - Luiz-Cerutti, Murilo
AU  - Luiz-Cerutti M
AD  - b Departamento de Ciencias Fisiologicas, Centro de Ciencias Biologicas , 
      Universidade Federal de Santa Catarina , Florianopolis , SC , Brazil.
FAU - Nascimento, Denise B
AU  - Nascimento DB
AD  - c Departamento de Quimica, Centro de Ciencias Naturais e Exatas , Universidade 
      Federal de Santa Maria , Santa Maria , RS , Brazil.
FAU - Farina, Marcelo
AU  - Farina M
AD  - d Departamento de Bioquimica, Centro de Ciencias Biologicas , Universidade 
      Federal de Santa Catarina , Florianopolis , SC , Brazil.
FAU - Soares Santos, Adair Roberto
AU  - Soares Santos AR
AD  - b Departamento de Ciencias Fisiologicas, Centro de Ciencias Biologicas , 
      Universidade Federal de Santa Catarina , Florianopolis , SC , Brazil.
FAU - de Azevedo Maia, Alcibia Helena
AU  - de Azevedo Maia AH
AD  - e Departamento de Patologia, Centro de Ciencias da Saude , Universidade Federal 
      de Santa Catarina , Florianopolis , SC , Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170829
PL  - England
TA  - J Toxicol Environ Health A
JT  - Journal of toxicology and environmental health. Part A
JID - 100960995
RN  - 0 (Environmental Pollutants)
RN  - 0 (Methylmercury Compounds)
SB  - IM
MH  - Animals
MH  - Blood/*drug effects
MH  - Blood Chemical Analysis
MH  - Cerebellum/*drug effects/metabolism
MH  - Environmental Pollutants/*toxicity
MH  - Liver/*drug effects/metabolism
MH  - Male
MH  - Methylmercury Compounds/*toxicity
MH  - Mice
MH  - Motor Activity/*drug effects
EDAT- 2017/08/30 06:00
MHDA- 2017/11/29 06:00
CRDT- 2017/08/30 06:00
PHST- 2017/08/30 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2017/08/30 06:00 [entrez]
AID - 10.1080/15287394.2017.1357324 [doi]
PST - ppublish
SO  - J Toxicol Environ Health A. 2017;80(19-21):1145-1155. doi: 
      10.1080/15287394.2017.1357324. Epub 2017 Aug 29.