PMID- 28851339
OWN - NLM
STAT- MEDLINE
DCOM- 20180321
LR  - 20181202
IS  - 1471-244X (Electronic)
IS  - 1471-244X (Linking)
VI  - 17
IP  - 1
DP  - 2017 Aug 29
TI  - Comorbid post-traumatic stress disorder in alcohol use disorder: relationships to 
      demography, drinking and neuroimmune profile.
PG  - 312
LID - 10.1186/s12888-017-1479-8 [doi]
LID - 312
AB  - BACKGROUND: This study examined how alcohol use disorder (AUD) patients with 
      post-traumatic stress disorder (PTSD) differed from those without PTSD in terms 
      of demography, drinking patterns and C-reactive protein, inflammatory cytokines, 
      tryptophan metabolism parameters, and brain-derived neurotrophic factor (BDNF). 
      METHODS: A consecutive sample (N = 187) of treatment-receiving AUD individuals 
      were recruited from Nepalese facilities. They underwent fully structured 
      psychiatric interviews. Serum levels of inflammatory cytokines [interleukin 
      (IL)-6, IL-1 Receptor antagonist (IL-1Ra), IL-10, tumor necrosis factor-alpha 
      (TNF-alpha), and interferon-gamma (IFN-gamma)] were determined by a multiplex assay, 
      kynurenine and tryptophan levels by high-performance liquid chromatography, and 
      BDNF by enzyme-linked immunosorbent assay (ELISA). RESULTS: The prevalence of 
      exposure to severe trauma and PTSD was 74% and 17%, respectively. PTSD 
      comorbidity was not associated with age, gender, or socioeconomic status, but 
      with co-occurring major depression, history of attempted suicide, earlier peak of 
      drinking problems, higher drinking quantity and withdrawal symptoms, experiencing 
      alcoholic blackouts, and drinking problems among parents. None of the assessed 
      neuroimmune parameters was related to comorbid PTSD. CONCLUSIONS: The findings 
      support routine trauma screening in AUD treatment samples and screening for risky 
      drinking in trauma populations to help guide interventions. The expected 
      aberrations in neuroimmune functioning may not be found when examined in a sample 
      with multiple psychiatric morbidities.
FAU - Neupane, Sudan Prasad
AU  - Neupane SP
AUID- ORCID: 0000-0002-7389-4178
AD  - Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health 
      Disorders, Innlandet Hospital Trust, Post box 104, 2381, Brumunddal, Norway. 
      Sudan.Prasad.Neupane@sykehuset-innlandet.no.
AD  - Norwegian Centre for Addiction Research (SERAF), University of Oslo, Oslo, 
      Norway. Sudan.Prasad.Neupane@sykehuset-innlandet.no.
FAU - Bramness, Jorgen G
AU  - Bramness JG
AD  - Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health 
      Disorders, Innlandet Hospital Trust, Post box 104, 2381, Brumunddal, Norway.
FAU - Lien, Lars
AU  - Lien L
AD  - Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health 
      Disorders, Innlandet Hospital Trust, Post box 104, 2381, Brumunddal, Norway.
AD  - Department of Public Health, Hedmark University College, Elverum, Norway.
LA  - eng
PT  - Journal Article
DEP - 20170829
PL  - England
TA  - BMC Psychiatry
JT  - BMC psychiatry
JID - 100968559
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alcohol Drinking
MH  - Alcoholism/complications/*epidemiology/psychology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Comorbidity
MH  - *Earthquakes
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Nepal/epidemiology
MH  - Prevalence
MH  - Stress Disorders, Post-Traumatic/blood/complications/*epidemiology/psychology
MH  - Young Adult
PMC - PMC5576315
OTO - NOTNLM
OT  - Alcohol use disorder
OT  - Brain-derived neurotrophic factor
OT  - Comorbidity
OT  - Cytokine
OT  - Post-traumatic stress disorder
OT  - Tryptophan metabolism
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Literate participants provided 
      written informed consent before enrolment. Participants unable to read or write 
      provided a thumb print together with a signature from a witness confirming their 
      voluntary participation. The study was approved by the Regional Committee for 
      Medical Research Ethics of Norway and the National Health Research Council of 
      Nepal. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors 
      declare that they have no competing interests. PUBLISHER'S NOTE: Springer Nature 
      remains neutral with regard to jurisdictional claims in published maps and 
      institutional affiliations.
EDAT- 2017/08/31 06:00
MHDA- 2018/03/22 06:00
PMCR- 2017/08/29
CRDT- 2017/08/31 06:00
PHST- 2017/02/26 00:00 [received]
PHST- 2017/08/22 00:00 [accepted]
PHST- 2017/08/31 06:00 [entrez]
PHST- 2017/08/31 06:00 [pubmed]
PHST- 2018/03/22 06:00 [medline]
PHST- 2017/08/29 00:00 [pmc-release]
AID - 10.1186/s12888-017-1479-8 [pii]
AID - 1479 [pii]
AID - 10.1186/s12888-017-1479-8 [doi]
PST - epublish
SO  - BMC Psychiatry. 2017 Aug 29;17(1):312. doi: 10.1186/s12888-017-1479-8.