PMID- 28853924
OWN - NLM
STAT- MEDLINE
DCOM- 20180706
LR  - 20220321
IS  - 1545-2948 (Electronic)
IS  - 0066-4197 (Linking)
VI  - 51
DP  - 2017 Nov 27
TI  - Regulation by 3'-Untranslated Regions.
PG  - 171-194
LID - 10.1146/annurev-genet-120116-024704 [doi]
AB  - 3'-untranslated regions (3'-UTRs) are the noncoding parts of mRNAs. Compared to 
      yeast, in humans, median 3'-UTR length has expanded approximately tenfold 
      alongside an increased generation of alternative 3'-UTR isoforms. In contrast, 
      the number of coding genes, as well as coding region length, has remained 
      similar. This suggests an important role for 3'-UTRs in the biology of higher 
      organisms. 3'-UTRs are best known to regulate diverse fates of mRNAs, including 
      degradation, translation, and localization, but they can also function like long 
      noncoding or small RNAs, as has been shown for whole 3'-UTRs as well as for 
      cleaved fragments. Furthermore, 3'-UTRs determine the fate of proteins through 
      the regulation of protein-protein interactions. They facilitate cotranslational 
      protein complex formation, which establishes a role for 3'-UTRs as evolved 
      eukaryotic operons. Whereas bacterial operons promote the interaction of two 
      subunits, 3'-UTRs enable the formation of protein complexes with diverse 
      compositions. All of these 3'-UTR functions are accomplished by effector proteins 
      that are recruited by RNA-binding proteins that bind to 3'-UTR cis-elements. In 
      summary, 3'-UTRs seem to be major players in gene regulation that enable local 
      functions, compartmentalization, and cooperativity, which makes them important 
      tools for the regulation of phenotypic diversity of higher organisms.
FAU - Mayr, Christine
AU  - Mayr C
AD  - Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer 
      Center, New York, NY 10065, USA; email: mayrc@mskcc.org.
LA  - eng
GR  - P30 CA008748/CA/NCI NIH HHS/United States
GR  - U01 CA164190/CA/NCI NIH HHS/United States
GR  - DP1 GM123454/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20170830
PL  - United States
TA  - Annu Rev Genet
JT  - Annual review of genetics
JID - 0117605
RN  - 0 (3' Untranslated Regions)
RN  - 0 (Molecular Motor Proteins)
RN  - 0 (RNA Isoforms)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - *3' Untranslated Regions
MH  - Animals
MH  - Bacteria/genetics/metabolism
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Molecular Motor Proteins/genetics/metabolism
MH  - Polyadenylation
MH  - Protein Binding
MH  - *Protein Biosynthesis
MH  - Protein Interaction Mapping
MH  - RNA Isoforms/*genetics/metabolism
MH  - RNA-Binding Proteins/*genetics/metabolism
MH  - Saccharomyces cerevisiae/genetics/metabolism
OTO - NOTNLM
OT  - RNA-binding proteins
OT  - accessibility of regulatory elements
OT  - alternative 3'-UTRs
OT  - alternative polyadenylation
OT  - cellular organization
OT  - cooperativity
OT  - cotranslational protein complex formation
OT  - mRNA localization
OT  - noncoding RNA
OT  - regulatory RNA
EDAT- 2017/08/31 06:00
MHDA- 2018/07/07 06:00
CRDT- 2017/08/31 06:00
PHST- 2017/08/31 06:00 [pubmed]
PHST- 2018/07/07 06:00 [medline]
PHST- 2017/08/31 06:00 [entrez]
AID - 10.1146/annurev-genet-120116-024704 [doi]
PST - ppublish
SO  - Annu Rev Genet. 2017 Nov 27;51:171-194. doi: 10.1146/annurev-genet-120116-024704. 
      Epub 2017 Aug 30.