PMID- 28854002
OWN - NLM
STAT- MEDLINE
DCOM- 20180522
LR  - 20180522
IS  - 1541-1087 (Electronic)
IS  - 0731-5724 (Linking)
VI  - 36
IP  - 7
DP  - 2017 Sep-Oct
TI  - Efficacy of Folic Acid Therapy in Patients with Hyperhomocysteinemia.
PG  - 528-532
LID - 10.1080/07315724.2017.1330162 [doi]
AB  - BACKGROUND: Increased plasma homocysteine (Hcy) levels are a risk factor for 
      stroke and can be reduced with folic acid therapy. Therefore, it is extremely 
      important for patients with hyperhomocysteinemia (HHcy) to obtain the normal 
      level of Hcy after folate intervention. Thus far, few studies have reported the 
      effective rate defined as percentage of patients who achieved normal plasma Hcy 
      levels after folic acid therapy. OBJECTIVES: The present study aimed to 
      investigate the effective rate of folic acid for the treatment of HHcy and the 
      impact of plasma baseline Hcy levels and the compliance of oral folic acid on the 
      efficacy. METHODS: A total of 858 patients with HHcy were treated with oral folic 
      acid (5 mg/d) for 3 months. Fasting blood samples collected at baseline and at 
      the end of treatment were assayed for plasma Hcy levels. RESULTS: After 3 months 
      of treatment, the plasma Hcy levels of 484 patients were reduced to below the 
      normal levels (15 mumol/L), corresponding to an effective rate of 56.41%. The 
      average of Hcy levels decreased by 28.05%. The effective rates of folic acid 
      therapy in a mild Hcy elevated group and an intermediate Hcy elevated group were 
      61.34% and 27.78%, respectively (p = 0.000). The effective rates among patients 
      with good and poor compliance of oral folic acid were 65.29% and 35.18%, 
      respectively (p = 0.000). CONCLUSIONS: More than 40% patients with HHcy failed to 
      reach the normal range (5-15 mumol/L) after 3 months of folic acid 
      supplementation. Further prospective studies are warranted to explore the reasons 
      for failure.
FAU - Tian, Huizi
AU  - Tian H
AUID- ORCID: 0000-0002-0762-4938
AD  - a Department of Epidemiology, School of Public Health , Zhengzhou University , 
      Zhengzhou , Henan , China.
FAU - Tian, Dandan
AU  - Tian D
AD  - a Department of Epidemiology, School of Public Health , Zhengzhou University , 
      Zhengzhou , Henan , China.
FAU - Zhang, Chengda
AU  - Zhang C
AD  - b Department of Biostatistics and Bioinformatics, School of Public Health and 
      Tropical Medicine , Tulane University , New Orleans , Louisiana , USA.
FAU - Wang, Wenhua
AU  - Wang W
AD  - a Department of Epidemiology, School of Public Health , Zhengzhou University , 
      Zhengzhou , Henan , China.
FAU - Wang, Lianke
AU  - Wang L
AD  - a Department of Epidemiology, School of Public Health , Zhengzhou University , 
      Zhengzhou , Henan , China.
FAU - Ge, Mengying
AU  - Ge M
AD  - a Department of Epidemiology, School of Public Health , Zhengzhou University , 
      Zhengzhou , Henan , China.
FAU - Hou, Quanliang
AU  - Hou Q
AD  - a Department of Epidemiology, School of Public Health , Zhengzhou University , 
      Zhengzhou , Henan , China.
FAU - Zhang, Weidong
AU  - Zhang W
AD  - a Department of Epidemiology, School of Public Health , Zhengzhou University , 
      Zhengzhou , Henan , China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20170830
PL  - United States
TA  - J Am Coll Nutr
JT  - Journal of the American College of Nutrition
JID - 8215879
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 12001-76-2 (Vitamin B Complex)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Aged
MH  - Dietary Supplements
MH  - Female
MH  - Folic Acid/pharmacology/*therapeutic use
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
MH  - Treatment Outcome
MH  - Vitamin B Complex/pharmacology/*therapeutic use
OTO - NOTNLM
OT  - Folic acid
OT  - baseline level
OT  - compliance
OT  - effective rate
OT  - hyperhomocysteinemia
EDAT- 2017/08/31 06:00
MHDA- 2018/05/23 06:00
CRDT- 2017/08/31 06:00
PHST- 2017/08/31 06:00 [pubmed]
PHST- 2018/05/23 06:00 [medline]
PHST- 2017/08/31 06:00 [entrez]
AID - 10.1080/07315724.2017.1330162 [doi]
PST - ppublish
SO  - J Am Coll Nutr. 2017 Sep-Oct;36(7):528-532. doi: 10.1080/07315724.2017.1330162. 
      Epub 2017 Aug 30.