PMID- 28854146
OWN - NLM
STAT- MEDLINE
DCOM- 20180625
LR  - 20180625
IS  - 2191-0308 (Electronic)
IS  - 0048-7554 (Linking)
VI  - 32
IP  - 4
DP  - 2017 Dec 20
TI  - Evaluation of the carcinogenic risks at the influence of POPs.
PG  - 373-378
LID - 10.1515/reveh-2017-0016 [doi]
AB  - INTRODUCTION: Kazakhstan is included in the list of environmentally vulnerable 
      countries and Kyzylorda oblast in particular. This is due to its geographical, 
      spatial and temporal and socioeconomic features. MATERIALS AND METHODS: As part 
      of the program "Integrated approaches in the management of public health in the 
      Aral region", we have carried out an expertise on many samples of natural 
      environments and products. Samples were selected in accordance with sampling 
      procedures according to regulatory documents by specialists of the Pesticide 
      Toxicology Laboratory. It is accredited by the State Standard of the Republic of 
      Kazakhstan, for compliance with ST RK ISO/IEC 17025-2007 "General requirements 
      for the competence of test and calibration laboratories". Gas chromatograph was 
      used for the determination of residues of organochlorine pesticides. For the 
      determination of dioxins, polychlorinated biphenyl was conducted on the gas 
      chromatomass spectrometer with quadruple detector produce by Agilent Company, 
      USA. To assess the risk, we carried out the mathematical calculations according 
      to the risk of chemicals polluting (No P 2.1.10.1920-04, Russia). Calculation of 
      the carcinogenic risk was carried out with the use of data on the size of the 
      exposure and meanings of carcinogenic potential factors (slope factor and unit 
      risk). RESULTS AND DISCUSSION: The evaluation of persistent organic pollutants 
      (POPs), based on the previous results of the research concerning water, soil and 
      food products, was held in five population settlements in Kyzylorda oblast 
      villages: Ayteke bi, Zhalagash, Zhosaly, Shieli and Aralsk town. Pollution with 
      the POPs in the environmental objects by means of exposition and evaluation of 
      the carcinogenic risk to human health is confirmed by the data of the statistical 
      reporting about some morbidity in Kyzylorda oblast, such as skin diseases and 
      subcutaneous tissue, endocrine system diseases, pregnancy complications etc. 
      CONCLUSION: The received levels of carcinogenic risks, which were first carried 
      out in the Republic of Kazakhstan in the village of Shieli, meet the third-risk 
      range, which is not acceptable to the life of the population that again shows the 
      problem of the Aral Sea, called the zone of ecological disaster.
FAU - Nazhmetdinova, Aiman
AU  - Nazhmetdinova A
AD  - .
FAU - Kassymbayev, Adlet
AU  - Kassymbayev A
AD  - .
FAU - Chalginbayeva, Altinay
AU  - Chalginbayeva A
AD  - .
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Rev Environ Health
JT  - Reviews on environmental health
JID - 0425754
RN  - 0 (Carcinogens)
RN  - 0 (Soil Pollutants)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Animals
MH  - Carcinogens/*analysis
MH  - Environmental Monitoring
MH  - Fishes
MH  - Food Contamination/*analysis
MH  - Kazakhstan
MH  - Milk/chemistry
MH  - Oryza/chemistry
MH  - Risk Assessment
MH  - Soil Pollutants/*analysis
MH  - Water Pollutants, Chemical/*analysis
OTO - NOTNLM
OT  - carcinogenic risks
OT  - ecological diseases
OT  - natural environments
OT  - persistent organic pollutants
EDAT- 2017/08/31 06:00
MHDA- 2018/06/26 06:00
CRDT- 2017/08/31 06:00
PHST- 2017/05/18 00:00 [received]
PHST- 2017/07/04 00:00 [accepted]
PHST- 2017/08/31 06:00 [pubmed]
PHST- 2018/06/26 06:00 [medline]
PHST- 2017/08/31 06:00 [entrez]
AID - /j/reveh.ahead-of-print/reveh-2017-0016/reveh-2017-0016.xml [pii]
AID - 10.1515/reveh-2017-0016 [doi]
PST - ppublish
SO  - Rev Environ Health. 2017 Dec 20;32(4):373-378. doi: 10.1515/reveh-2017-0016.