PMID- 28855412
OWN - NLM
STAT- MEDLINE
DCOM- 20171128
LR  - 20210109
IS  - 1744-957X (Electronic)
IS  - 1744-9561 (Print)
IS  - 1744-9561 (Linking)
VI  - 13
IP  - 8
DP  - 2017 Aug
TI  - Responses of neurogenesis and neuroplasticity related genes to elevated CO(2) 
      levels in the brain of three teleost species.
LID - 10.1098/rsbl.2017.0240 [doi]
LID - 20170240
AB  - The continuous increase of anthropogenic CO(2) in the atmosphere resulting in 
      ocean acidification has been reported to affect brain function in some fishes. 
      During adulthood, cell proliferation is fundamental for fish brain growth and for 
      it to adapt in response to external stimuli, such as environmental changes. Here 
      we report the first expression study of genes regulating neurogenesis and 
      neuroplasticity in brains of three-spined stickleback (Gasterosteus aculeatus), 
      cinnamon anemonefish (Amphiprion melanopus) and spiny damselfish (Acanthochromis 
      polyacanthus) exposed to elevated CO(2) The mRNA expression levels of the 
      neurogenic differentiation factor (NeuroD) and doublecortin (DCX) were 
      upregulated in three-spined stickleback exposed to high-CO(2) compared with 
      controls, while no changes were detected in the other species. The mRNA 
      expression levels of the proliferating cell nuclear antigen (PCNA) and the 
      brain-derived neurotrophic factor (BDNF) remained unaffected in the high-CO(2) 
      exposed groups compared to the control in all three species. These results 
      indicate a species-specific regulation of genes involved in neurogenesis in 
      response to elevated ambient CO(2) levels. The higher expression of NeuroD and 
      DCX mRNA transcripts in the brain of high-CO(2)-exposed three-spined stickleback, 
      together with the lack of effects on mRNA levels in cinnamon anemonefish and 
      spiny damselfish, indicate differences in coping mechanisms among fish in 
      response to the predicted-future CO(2) level.
CI  - (c) 2017 The Author(s).
FAU - Lai, Floriana
AU  - Lai F
AUID- ORCID: 0000-0001-6683-4882
AD  - Department of Biosciences, University of Oslo, Oslo, Norway 
      floriana.lai@ibv.uio.no.
FAU - Fagernes, Cathrine E
AU  - Fagernes CE
AD  - Department of Biosciences, University of Oslo, Oslo, Norway.
FAU - Bernier, Nicholas J
AU  - Bernier NJ
AUID- ORCID: 0000-0003-4953-7063
AD  - Department of Integrative Biology, University of Guelph, Guelph, Canada.
FAU - Miller, Gabrielle M
AU  - Miller GM
AD  - Institute for Biology and Environmental Science, Carl von Ossietzky University 
      Oldenburg, Oldenburg, Germany.
FAU - Munday, Philip L
AU  - Munday PL
AD  - ARC Centre of Excellence for Coral Reef Studies, James Cook University, 
      Townsville, Australia.
FAU - Jutfelt, Fredrik
AU  - Jutfelt F
AD  - Department of Biology, Norwegian University of Science and Technology, Trondheim, 
      Norway.
FAU - Nilsson, Goran E
AU  - Nilsson GE
AD  - Department of Biosciences, University of Oslo, Oslo, Norway.
LA  - eng
SI  - Dryad/10.5061/dryad.pn397
SI  - figshare/10.6084/m9.figshare.c.3855904
PT  - Journal Article
PL  - England
TA  - Biol Lett
JT  - Biology letters
JID - 101247722
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Animals
MH  - Brain
MH  - Brain-Derived Neurotrophic Factor
MH  - Carbon Dioxide
MH  - Fishes
MH  - *Neurogenesis
MH  - *Neuronal Plasticity
MH  - Smegmamorpha
PMC - PMC5582102
OTO - NOTNLM
OT  - *cinnamon anemonefish
OT  - *elevated CO2
OT  - *neurogenesis
OT  - *spiny damselfish
OT  - *three-spined stickleback
COIS- We have no competing interests.
EDAT- 2017/09/01 06:00
MHDA- 2017/11/29 06:00
PMCR- 2018/08/01
CRDT- 2017/09/01 06:00
PHST- 2017/04/16 00:00 [received]
PHST- 2017/08/08 00:00 [accepted]
PHST- 2017/09/01 06:00 [entrez]
PHST- 2017/09/01 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2018/08/01 00:00 [pmc-release]
AID - rsbl.2017.0240 [pii]
AID - rsbl20170240 [pii]
AID - 10.1098/rsbl.2017.0240 [doi]
PST - ppublish
SO  - Biol Lett. 2017 Aug;13(8):20170240. doi: 10.1098/rsbl.2017.0240.