PMID- 28855876
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 8
DP  - 2017
TI  - The Non-Peptide Arginine-Vasopressin v(1a) Selective Receptor Antagonist, 
      SR49059, Blocks the Rewarding, Prosocial, and Anxiolytic Effects of 
      3,4-Methylenedioxymethamphetamine and Its Derivatives in Zebra Fish.
PG  - 146
LID - 10.3389/fpsyt.2017.00146 [doi]
LID - 146
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) and its derivatives, 
      2,5-dimethoxy-4-bromo-amphetamine hydrobromide (DOB) and para-methoxyamphetamine 
      (PMA), are recreational drugs whose pharmacological effects have recently been 
      attributed to serotonin 5HT(2A/C) receptors. However, there is growing evidence 
      that the oxytocin (OT)/vasopressin system can modulate some the effects of MDMA. 
      In this study, MDMA (2.5-10 mg/kg), DOB (0.5 mg/kg), or PMA (0.005, 0.1, or 
      0.25 mg/kg) were administered intramuscularly to adult zebra fish, alone or in 
      combination with the V(1a) vasopressin antagonist, SR49059 (0.01-1 ng/kg), before 
      carrying out conditioned place preference (CPP), social preference, novel tank 
      diving, and light-dark tests in order to evaluate subsequent rewarding, social, 
      and emotional-like behavior. The combination of SR49059 and each drug 
      progressively blocked: (1) rewarding behavior as measured by CPP in terms of time 
      spent in drug-paired compartment; (2) prosocial effects measured on the basis of 
      the time spent in the proximity of a nacre fish picture; and (3) anxiolytic 
      effects in terms of the time spent in the upper half of the novel tank and in the 
      white compartment of the tank used for the light-dark test. Antagonism was 
      obtained at SR49059 doses which, when given alone, did not change motor function. 
      In comparison with a control group, receiving vehicle alone, there was a three to 
      five times increase in the brain release of isotocin (the analog of OT in fish) 
      after treatment with the most active doses of MDMA (10 mg/kg), DOB (0.5 mg/kg), 
      and PMA (0.1 mg/kg) as evaluated by means of bioanalytical reversed-phase 
      high-performance liquid chromatography. Taken together, these findings show that 
      the OT/vasopressin system is involved in the rewarding, prosocial, and anxiolytic 
      effects of MDMA, DOB, and PMA in zebra fish and underline the association between 
      this system and the behavioral alterations associated with disorders related to 
      substance abuse.
FAU - Ponzoni, Luisa
AU  - Ponzoni L
AD  - Fondazione Umberto Veronesi, Milan, Italy.
FAU - Braida, Daniela
AU  - Braida D
AD  - Department of Medical Biotechnology and Translational Medicine (BIOMETRA), 
      Universita degli Studi di Milano, Milan, Italy.
FAU - Bondiolotti, Gianpietro
AU  - Bondiolotti G
AD  - Department of Medical Biotechnology and Translational Medicine (BIOMETRA), 
      Universita degli Studi di Milano, Milan, Italy.
FAU - Sala, Mariaelvina
AU  - Sala M
AD  - Institute of Neuroscience, Consiglio Nazionale delle Ricerche (CNR), Milan, 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20170814
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC5557732
OTO - NOTNLM
OT  - hallucinogens
OT  - isotocin
OT  - light-dark test
OT  - novel tank diving test
OT  - phenethylamines
OT  - social preference
OT  - zebra fish
EDAT- 2017/09/01 06:00
MHDA- 2017/09/01 06:01
PMCR- 2017/08/14
CRDT- 2017/09/01 06:00
PHST- 2017/05/26 00:00 [received]
PHST- 2017/07/27 00:00 [accepted]
PHST- 2017/09/01 06:00 [entrez]
PHST- 2017/09/01 06:00 [pubmed]
PHST- 2017/09/01 06:01 [medline]
PHST- 2017/08/14 00:00 [pmc-release]
AID - 10.3389/fpsyt.2017.00146 [doi]
PST - epublish
SO  - Front Psychiatry. 2017 Aug 14;8:146. doi: 10.3389/fpsyt.2017.00146. eCollection 
      2017.