PMID- 28856088
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231112
IS  - 2213-0071 (Print)
IS  - 2213-0071 (Electronic)
IS  - 2213-0071 (Linking)
VI  - 22
DP  - 2017
TI  - Syndrome of inappropriate secretion of anti-diuretic hormone (SIADH) as an 
      initial presenting sign of non small cell lung cancer-case report and literature 
      review.
PG  - 164-167
LID - 10.1016/j.rmcr.2017.08.004 [doi]
AB  - Association of SIADH with malignancy was first reported in 1957, when it was 
      described in two patients with bronchogenic carcinoma. While the association with 
      small cell lung cancer (SCLC) is well known, that with non small cell lung cancer 
      (NSCLC) has been rarely reported. We report a case of 70 year old male who was 
      found to have hyponatremia secondary to SIADH. Radiological tests revealed right 
      hilar lung mass with mediastinal adenopathy. Bronchoscopic biopsy revealed 
      non-small cell lung cancer of type squamous cell. Magnetic resonance imaging 
      (MRI) of brain showed metastatic lesions, thereby confirming diagnosis of 
      metastatic lung cancer. Paraneoplastic syndromes occur in 10% of lung cancer 
      cases and they represent a group of disorders related to secretion of functional 
      polypeptides or hormones from tumor cells. SIADH is more commonly described in 
      conjunction with small cell lung cancer but there are a few case reports 
      describing it's occurrence after initiation of therapy for NSCLC such as 
      radiation and chemotherapy. The mechanism for this phenomenon is not known. 
      Unlike infectious causes, hyponatremia as initial presentation is an uncommon 
      feature of malignancy-associated SIADH. In the lung cancer population, 
      hyponatremia has been identified as a negative prognostic factor in hospitalized 
      patients and those with advanced-stage disease. Malignancy should be a 
      consideration in the diagnostic evaluation of SIADH, irrespective of the time of 
      presentation.
FAU - Iyer, Praneet
AU  - Iyer P
AD  - Department of Pulmonary and Critical Care, University of Tennessee Health Science 
      Center, Memphis, TN, USA.
FAU - Ibrahim, Mohammad
AU  - Ibrahim M
AD  - Saint Francis Medical Center, Seton Hall University, Trenton, NJ, USA.
FAU - Siddiqui, Waqas
AU  - Siddiqui W
AD  - Department of Nephrology, Drexel University College of Medicine, Philadelphia, 
      PA, USA.
FAU - Dirweesh, Ahmed
AU  - Dirweesh A
AD  - Saint Francis Medical Center, Seton Hall University, Trenton, NJ, USA.
LA  - eng
PT  - Case Reports
DEP - 20170811
PL  - England
TA  - Respir Med Case Rep
JT  - Respiratory medicine case reports
JID - 101604463
PMC - PMC5565784
OTO - NOTNLM
OT  - Hyponatremia
OT  - Non small cell lung cancer
OT  - Syndrome of inappropriate ADH secretion
EDAT- 2017/09/01 06:00
MHDA- 2017/09/01 06:01
PMCR- 2017/08/11
CRDT- 2017/09/01 06:00
PHST- 2017/07/10 00:00 [received]
PHST- 2017/08/06 00:00 [revised]
PHST- 2017/08/07 00:00 [accepted]
PHST- 2017/09/01 06:00 [entrez]
PHST- 2017/09/01 06:00 [pubmed]
PHST- 2017/09/01 06:01 [medline]
PHST- 2017/08/11 00:00 [pmc-release]
AID - S2213-0071(17)30238-1 [pii]
AID - 10.1016/j.rmcr.2017.08.004 [doi]
PST - epublish
SO  - Respir Med Case Rep. 2017 Aug 11;22:164-167. doi: 10.1016/j.rmcr.2017.08.004. 
      eCollection 2017.