PMID- 28857460
OWN - NLM
STAT- MEDLINE
DCOM- 20190828
LR  - 20190828
IS  - 1369-1600 (Electronic)
IS  - 1355-6215 (Linking)
VI  - 23
IP  - 3
DP  - 2018 May
TI  - Working memory and salivary brain-derived neurotrophic factor as developmental 
      predictors of cocaine seeking in male and female rats.
PG  - 868-879
LID - 10.1111/adb.12535 [doi]
AB  - Poor working memory is linked to future risk-taking behaviors. Lifelong risk of 
      habitual drug use is highest in individuals who initiate use in early 
      adolescence. We sought to determine in rats whether juvenile traits, specifically 
      poor working memory and low salivary brain-derived neurotrophic factor (BDNF), 
      are related to elevated cocaine taking and relapse in adolescence and adulthood. 
      On postnatal day (P) 20, working memory was assessed using the novel object 
      recognition task in male and female rats. Saliva was assayed at P20 for BDNF 
      before cocaine self-administration on P28 [0.75 or 0.25 mg/kg/infusion for 
      30 days under a fixed-ratio (FR) 1 to FR5 schedule] and on P94 before relapse 
      after 30-day abstinence in adulthood. A separate cohort of P28 male rats was 
      assayed for object discrimination and BDNF in saliva and the medial prefrontal 
      cortex and dorsolateral striatum. Novel object discrimination correlated 
      positively with salivary BDNF on P20 and dorsolateral striatum levels, but 
      negatively with medial prefrontal cortex BDNF in male rats. In female rats, P20 
      salivary BDNF negatively correlated with object discrimination. Salivary BDNF 
      positively correlated across age in male rats. Male rats earned more cocaine 
      (0.75 mg/kg) at FR5 and responded more at relapse than did female rats. These 
      elevated relapse rates in male rats were significantly associated with P20 object 
      discrimination and salivary BDNF. Relapse after 0.75 and 0.25 mg/kg in female 
      rats correlated only with object discrimination. In conclusion, poor working 
      memory and low salivary BDNF in juvenile male rats may represent biomarkers for 
      later cocaine use. Further research is needed to identify biomarkers for risk in 
      male rats.
CI  - (c) 2017 Society for the Study of Addiction.
FAU - Jordan, Chloe J
AU  - Jordan CJ
AUID- ORCID: 0000-0002-1843-227X
AD  - Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, 
      USA.
FAU - Andersen, Susan L
AU  - Andersen SL
AD  - Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, 
      USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170831
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cocaine/*administration & dosage
MH  - Corpus Striatum/metabolism
MH  - Dopamine Uptake Inhibitors/*administration & dosage
MH  - *Drug-Seeking Behavior
MH  - Female
MH  - Male
MH  - *Memory, Short-Term
MH  - Prefrontal Cortex/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Risk Assessment
MH  - Saliva/chemistry
MH  - Self Administration
MH  - Sex Factors
OTO - NOTNLM
OT  - adolescence
OT  - brain-derived neurotrophic factor
OT  - cocaine self-administration
OT  - saliva
OT  - sex differences
OT  - working memory
EDAT- 2017/09/01 06:00
MHDA- 2019/08/29 06:00
CRDT- 2017/09/01 06:00
PHST- 2017/01/04 00:00 [received]
PHST- 2017/05/02 00:00 [revised]
PHST- 2017/06/12 00:00 [accepted]
PHST- 2017/09/01 06:00 [pubmed]
PHST- 2019/08/29 06:00 [medline]
PHST- 2017/09/01 06:00 [entrez]
AID - 10.1111/adb.12535 [doi]
PST - ppublish
SO  - Addict Biol. 2018 May;23(3):868-879. doi: 10.1111/adb.12535. Epub 2017 Aug 31.