PMID- 28857598 OWN - NLM STAT- MEDLINE DCOM- 20191025 LR - 20221207 IS - 1931-1559 (Electronic) IS - 0894-4105 (Linking) VI - 32 IP - 2 DP - 2018 Feb TI - Suicide attempt, clinical correlates, and BDNF Val66Met polymorphism in chronic patients with schizophrenia. PG - 199-205 LID - 10.1037/neu0000383 [doi] AB - OBJECTIVE: Recent evidence suggests the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of suicidal behavior. Because schizophrenia patients usually have high suicide rates and numerous studies have suggested that BDNF may contribute to the psychopathology of schizophrenia, we hypothesized that the functional polymorphism of BDNF (Val66Met) was associated with suicide attempts in patients with schizophrenia in a Chinese Han population. METHOD: This polymorphism was genotyped in 825 chronic schizophrenia patients with (n = 123) and without (n = 702) suicide attempts and 445 healthy controls without a history of suicide attempts using a case-control design. The schizophrenia symptoms were assessed by the Positive and Negative Syndrome Scale. RESULTS: There were no significant differences in BDNF Val66Met genotype and allele distributions between the patients and healthy controls. However, we found the Val allele (p = .023) and the Val/Val genotypes (p = .058) to be associated with a history of suicide attempts. Moreover, some clinical characteristics, including age and cigarettes smoked each day, interacted with the BDNF gene variant and appeared to play an important role in suicide attempts among schizophrenia patients. CONCLUSIONS: The BDNF Val66Met polymorphism itself and its interaction with some clinical variables may influence suicide attempts among schizophrenia patients. (PsycINFO Database Record CI - (c) 2018 APA, all rights reserved). FAU - Xia, Haisen AU - Xia H AD - Hefei Fourth People's Hospital, Anhui Mental Health Center. FAU - Zhang, Guangya AU - Zhang G AD - Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University. FAU - Du, Xiangdong AU - Du X AD - Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University. FAU - Zhang, Yingyang AU - Zhang Y AD - Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University. FAU - Yin, Guangzhong AU - Yin G AD - Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University. FAU - Dai, Jing AU - Dai J AD - Fourth People's Hospital of Chengdu, Chengdu Mental Health Center. FAU - He, Man-Xi AU - He MX AD - Fourth People's Hospital of Chengdu, Chengdu Mental Health Center. FAU - Soares, Jair C AU - Soares JC AD - Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston. FAU - Li, Xiaosi AU - Li X AD - Hefei Fourth People's Hospital, Anhui Mental Health Center. FAU - Zhang, Xiang Yang AU - Zhang XY AD - Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston. LA - eng PT - Journal Article DEP - 20170831 PL - United States TA - Neuropsychology JT - Neuropsychology JID - 8904467 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - Aged MH - Asian People MH - Brain-Derived Neurotrophic Factor/*genetics MH - Case-Control Studies MH - China/epidemiology MH - Chronic Disease MH - Female MH - Gene Frequency MH - Genotype MH - Humans MH - Male MH - Middle Aged MH - Polymorphism, Genetic MH - Polymorphism, Single Nucleotide MH - Schizophrenia/*genetics MH - Schizophrenic Psychology MH - Smoking/genetics MH - Suicide, Attempted/*statistics & numerical data EDAT- 2017/09/01 06:00 MHDA- 2019/10/28 06:00 CRDT- 2017/09/01 06:00 PHST- 2017/09/01 06:00 [pubmed] PHST- 2019/10/28 06:00 [medline] PHST- 2017/09/01 06:00 [entrez] AID - 2017-37797-001 [pii] AID - 10.1037/neu0000383 [doi] PST - ppublish SO - Neuropsychology. 2018 Feb;32(2):199-205. doi: 10.1037/neu0000383. Epub 2017 Aug 31.