PMID- 28858415
OWN - NLM
STAT- MEDLINE
DCOM- 20180523
LR  - 20181113
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 46
IP  - 7
DP  - 2017 Oct
TI  - Effects of pair bonding on parental behavior and dopamine activity in the nucleus 
      accumbens in male prairie voles.
PG  - 2276-2284
LID - 10.1111/ejn.13673 [doi]
AB  - Male parental care is a vital behavior for the development as well as the 
      physical and mental well-being of the young. However, little is known about the 
      neurochemical regulation of male parental behavior, mainly due to the lack of 
      appropriate animal models. In this study, we used the socially monogamous male 
      prairie vole (Microtus ochrogaster) to investigate the effect of pair-bonding 
      experience on paternal behavior and dopamine (DA) signaling in the nucleus 
      accumbens (NAcc) in the brain. We compared sexually naive males with males that 
      were pair bonded with a female for two weeks. Our data showed that pair-bonded 
      males displayed enhanced paternal behavior, particularly in pup licking/grooming, 
      associated with increased DA type-1 receptor (D1R) protein expression in the 
      NAcc, compared to sexually naive males. Site-specific brain microdialysis 
      revealed a significant, but transient, increase in DA release in the NAcc 
      associated with pup exposure in both groups of the males. Further, 
      pharmacological blockade of D1R in the NAcc decreased pup licking/grooming in the 
      pair-bonded males. Together, our data demonstrate that pair-bonding experience 
      with a female facilitated male parental behavior via NAcc D1R mediation in male 
      prairie voles.
CI  - (c) 2017 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
FAU - Lei, K
AU  - Lei K
AD  - Department of Psychology and Program in Neuroscience, Florida State University, 
      Tallahassee, FL, USA.
FAU - Liu, Y
AU  - Liu Y
AD  - Department of Psychology and Program in Neuroscience, Florida State University, 
      Tallahassee, FL, USA.
FAU - Smith, A S
AU  - Smith AS
AD  - Department of Psychology and Program in Neuroscience, Florida State University, 
      Tallahassee, FL, USA.
FAU - Lonstein, J S
AU  - Lonstein JS
AD  - Department of Psychology and Neuroscience Program, Michigan State University, 
      East Lansing, MI, USA.
FAU - Wang, Z
AU  - Wang Z
AUID- ORCID: 0000-0001-7372-3777
AD  - Department of Psychology and Program in Neuroscience, Florida State University, 
      Tallahassee, FL, USA.
LA  - eng
GR  - R01 MH058616/MH/NIMH NIH HHS/United States
GR  - R01 MH108527/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20170918
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Receptors, Dopamine D1)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Arvicolinae
MH  - Dopamine/*metabolism
MH  - Female
MH  - Grooming
MH  - Male
MH  - Nesting Behavior
MH  - Nucleus Accumbens/*metabolism/physiology
MH  - *Pair Bond
MH  - Receptors, Dopamine D1/metabolism
PMC - PMC5624856
MID - NIHMS903527
OTO - NOTNLM
OT  - D1R
OT  - dopamine
OT  - nucleus accumbens
OT  - pair bonding
OT  - paternal behavior
COIS- Conflict of interest The authors have no financial disclosures and have no 
      potential conflicts of interest.
EDAT- 2017/09/01 06:00
MHDA- 2018/05/24 06:00
PMCR- 2018/10/01
CRDT- 2017/09/01 06:00
PHST- 2017/05/11 00:00 [received]
PHST- 2017/08/14 00:00 [revised]
PHST- 2017/08/21 00:00 [accepted]
PHST- 2017/09/01 06:00 [pubmed]
PHST- 2018/05/24 06:00 [medline]
PHST- 2017/09/01 06:00 [entrez]
PHST- 2018/10/01 00:00 [pmc-release]
AID - 10.1111/ejn.13673 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2017 Oct;46(7):2276-2284. doi: 10.1111/ejn.13673. Epub 2017 Sep 
      18.