PMID- 28858646
OWN - NLM
STAT- MEDLINE
DCOM- 20180612
LR  - 20180817
IS  - 1879-0534 (Electronic)
IS  - 0010-4825 (Linking)
VI  - 89
DP  - 2017 Oct 1
TI  - Inferring the effects of saliva on liquid bolus flow using computer simulation.
PG  - 304-313
LID - S0010-4825(17)30238-X [pii]
LID - 10.1016/j.compbiomed.2017.07.014 [doi]
AB  - Computer simulation of liquid bolus flow is used to test the assumption that a 
      slip boundary condition approximates a healthy swallow due to the presence of 
      saliva lubricating the bolus. Six dynamic, 320-row area detector CT (ADCT) 
      sequences of normal subjects swallowing thin, nectar, and honey-thick liquids are 
      used in this work. The aerodigestive tract is segmented from the images in order 
      to create a dynamic 3D geometry, which is subsequently used to drive a Smoothed 
      Particle Hydrodynamics (SPH) fluid simulation of the bolus. The results show that 
      the no-slip simulation, approximating no-lubrication, provides a closer match to 
      the ADCT bolus images than the slip simulation, particularly in the oral phase. 
      This finding suggests that the role of saliva in swallowing liquid boluses is not 
      to lubricate the aerodigestive tract, and that there is another reason for its 
      importance in normal swallowing of liquids.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Ho, Andrew
AU  - Ho A
AD  - Electrical and Computer Engineering, University of British Columbia, Canada. 
      Electronic address: andrewkh@ece.ubc.ca.
FAU - Affoo, Rebecca
AU  - Affoo R
AD  - Speech-Language Pathology, University of Central Michigan, USA. Electronic 
      address: affoo1r@cmich.edu.
FAU - Rogus-Pulia, Nicole
AU  - Rogus-Pulia N
AD  - Department of Medicine, University of Wisconsin-Madison, USA; Geriatric Research 
      Education and Clinical Centre (GRECC), William S. Middleton Memorial Hospital, 
      USA. Electronic address: npulia@wisc.edu.
FAU - Nicosia, Mark
AU  - Nicosia M
AD  - Mechanical Engineering, Widener University, USA. Electronic address: 
      manicosia@widener.edu.
FAU - Inamoto, Yoko
AU  - Inamoto Y
AD  - Department of Rehabilitation Medicine I, Fujita Health University, Japan. 
      Electronic address: inamoto@fujita-hu.ac.jp.
FAU - Saitoh, Eiichi
AU  - Saitoh E
AD  - Department of Rehabilitation Medicine I, Fujita Health University, Japan. 
      Electronic address: esaitoh@fujita-hu.ac.jp.
FAU - Green, Sheldon
AU  - Green S
AD  - Mechanical Engineering, University of British Columbia, Canada. Electronic 
      address: Sheldon.Green@ubc.ca.
FAU - Fels, Sidney
AU  - Fels S
AD  - Electrical and Computer Engineering, University of British Columbia, Canada. 
      Electronic address: ssfels@ece.ubc.ca.
LA  - eng
GR  - CPG-121024/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170729
PL  - United States
TA  - Comput Biol Med
JT  - Computers in biology and medicine
JID - 1250250
SB  - IM
MH  - Adult
MH  - *Computer Simulation
MH  - *Deglutition Disorders/diagnostic imaging/physiopathology
MH  - Female
MH  - Humans
MH  - Hydrodynamics
MH  - *Models, Biological
MH  - *Saliva
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - 3D modelling
OT  - Deglutition
OT  - Deglutition disorders
OT  - Fluid simulation
OT  - Saliva
EDAT- 2017/09/01 06:00
MHDA- 2018/06/13 06:00
CRDT- 2017/09/01 06:00
PHST- 2017/05/05 00:00 [received]
PHST- 2017/07/15 00:00 [revised]
PHST- 2017/07/26 00:00 [accepted]
PHST- 2017/09/01 06:00 [pubmed]
PHST- 2018/06/13 06:00 [medline]
PHST- 2017/09/01 06:00 [entrez]
AID - S0010-4825(17)30238-X [pii]
AID - 10.1016/j.compbiomed.2017.07.014 [doi]
PST - ppublish
SO  - Comput Biol Med. 2017 Oct 1;89:304-313. doi: 10.1016/j.compbiomed.2017.07.014. 
      Epub 2017 Jul 29.