PMID- 28858760
OWN - NLM
STAT- MEDLINE
DCOM- 20171013
LR  - 20181113
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 159
DP  - 2017 Nov
TI  - Sex differences in sensitivity to prenatal and early childhood manganese exposure 
      on neuromotor function in adolescents.
PG  - 458-465
LID - S0013-9351(17)30508-X [pii]
LID - 10.1016/j.envres.2017.08.035 [doi]
AB  - INTRODUCTION: While studies have suggested that exposure to manganese (Mn) may be 
      associated with neurodevelopment in school-age children, there is limited 
      information on prenatal and postnatal Mn exposures and tremor or motor function 
      in children. METHODS: We measured Mn levels in dentine of shed teeth, 
      representing prenatal, early postnatal, and cumulative childhood exposure 
      windows, from 195 children (predominantly right-handed, 92%) in Italy. Pursuit 
      Aiming, Luria Nebraska Motor Battery, as well as Tremor and Sway system from 
      Computerized Adaptive Testing System (CATSYS) were administered at 11-14 years 
      old. We examined the relationships of tooth Mn (ln-transformed) with motor 
      function using multivariable linear regressions and generalized additive models, 
      adjusting for age, sex, and socioeconomic status index. Effect modification by 
      sex was also examined. RESULTS: We found that higher prenatal Mn was associated 
      with better body stability in boys in a number of sway tests (including mean 
      sway, transversal sway, sagittal sway, sway area, and sway intensity), while Mn 
      was associated with poorer performance in girls on all of these metrics (all p 
      for Mn x sex interaction < 0.05). Higher prenatal Mn was also modestly associated 
      with better hand/finger and eye-hand coordination in boys compared to girls in 
      sex-stratified analyses, although interaction models did not reach statistical 
      significance. For tremor, on the other hand, higher early postnatal Mn was 
      associated with increased right-hand center frequency in girls (p for interaction 
      < 0.01), but increased Mn level at the later postnatal period was associated with 
      increased center frequency in boys (p for interaction = 0.01). CONCLUSIONS: This 
      study, which used a direct measure of prenatal and childhood Mn exposure, 
      suggested sex-specific critical windows of early life Mn exposure in relation to 
      neuromotor function in adolescents. The sex-specific associations might be 
      strongest with measures of whole body stability, for which the critical exposure 
      window was during the prenatal period.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Chiu, Yueh-Hsiu Mathilda
AU  - Chiu YM
AD  - Department of Environmental Medicine and Public Health, Icahn School of Medicine 
      at Mount Sinai, New York, NY, USA; Department of Pediatrics, Icahn School of 
      Medicine at Mount Sinai, New York, NY, USA. Electronic address: 
      mathilda.chiu@mssm.edu.
FAU - Claus Henn, Birgit
AU  - Claus Henn B
AD  - Department of Environmental Health, Boston University School of Public Health, 
      Boston, MA, USA.
FAU - Hsu, Hsiao-Hsien Leon
AU  - Hsu HL
AD  - Department of Environmental Medicine and Public Health, Icahn School of Medicine 
      at Mount Sinai, New York, NY, USA.
FAU - Pendo, Mathew P
AU  - Pendo MP
AD  - Center for Medicine, Health and Society, Vanderbilt University College of Arts 
      and Science, Nashville, TN, USA.
FAU - Coull, Brent A
AU  - Coull BA
AD  - Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, 
      MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public 
      Health, Boston, MA, USA.
FAU - Austin, Christine
AU  - Austin C
AD  - Department of Environmental Medicine and Public Health, Icahn School of Medicine 
      at Mount Sinai, New York, NY, USA.
FAU - Cagna, Giuseppa
AU  - Cagna G
AD  - Department of Medical and Surgical Specialties, Radiological Sciences and Public 
      Health, Section of Occupational Medicine, University of Brescia, Brescia, Italy.
FAU - Fedrighi, Chiara
AU  - Fedrighi C
AD  - Department of Medical and Surgical Specialties, Radiological Sciences and Public 
      Health, Section of Occupational Medicine, University of Brescia, Brescia, Italy.
FAU - Placidi, Donatella
AU  - Placidi D
AD  - Department of Medical and Surgical Specialties, Radiological Sciences and Public 
      Health, Section of Occupational Medicine, University of Brescia, Brescia, Italy.
FAU - Smith, Donald R
AU  - Smith DR
AD  - Department of Microbiology and Environmental Toxicology, University of 
      California, Santa Cruz, USA.
FAU - Wright, Robert O
AU  - Wright RO
AD  - Department of Environmental Medicine and Public Health, Icahn School of Medicine 
      at Mount Sinai, New York, NY, USA; Department of Pediatrics, Icahn School of 
      Medicine at Mount Sinai, New York, NY, USA.
FAU - Lucchini, Roberto G
AU  - Lucchini RG
AD  - Department of Environmental Medicine and Public Health, Icahn School of Medicine 
      at Mount Sinai, New York, NY, USA; Department of Medical and Surgical 
      Specialties, Radiological Sciences and Public Health, Section of Occupational 
      Medicine, University of Brescia, Brescia, Italy.
FAU - Arora, Manish
AU  - Arora M
AD  - Department of Environmental Medicine and Public Health, Icahn School of Medicine 
      at Mount Sinai, New York, NY, USA.
LA  - eng
GR  - R01 ES026033/ES/NIEHS NIH HHS/United States
GR  - DP2 ES025453/ES/NIEHS NIH HHS/United States
GR  - R00 ES022986/ES/NIEHS NIH HHS/United States
GR  - P30 ES000002/ES/NIEHS NIH HHS/United States
GR  - R01 ES018990/ES/NIEHS NIH HHS/United States
GR  - R56 ES019222/ES/NIEHS NIH HHS/United States
GR  - R01 ES019222/ES/NIEHS NIH HHS/United States
GR  - R01 ES013744/ES/NIEHS NIH HHS/United States
GR  - R00 ES019597/ES/NIEHS NIH HHS/United States
GR  - P30 ES023515/ES/NIEHS NIH HHS/United States
GR  - T42OH008422/ACL HHS/United States
GR  - T42 OH008422/OH/NIOSH CDC HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170918
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 42Z2K6ZL8P (Manganese)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/chemistry
MH  - Child
MH  - Child Development/*drug effects
MH  - *Environmental Exposure
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Humans
MH  - Italy/epidemiology
MH  - Male
MH  - Manganese/*toxicity
MH  - Nervous System/*drug effects/growth & development
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/*epidemiology
MH  - Sex Factors
MH  - Tooth/chemistry
PMC - PMC5623637
MID - NIHMS902620
OTO - NOTNLM
OT  - Adolescents
OT  - Manganese
OT  - Motor function
OT  - Prenatal and postnatal exposure
OT  - Sex difference
OT  - Tooth biomarker
EDAT- 2017/09/01 06:00
MHDA- 2017/10/14 06:00
PMCR- 2018/11/01
CRDT- 2017/09/01 06:00
PHST- 2017/03/14 00:00 [received]
PHST- 2017/07/25 00:00 [revised]
PHST- 2017/08/18 00:00 [accepted]
PHST- 2017/09/01 06:00 [pubmed]
PHST- 2017/10/14 06:00 [medline]
PHST- 2017/09/01 06:00 [entrez]
PHST- 2018/11/01 00:00 [pmc-release]
AID - S0013-9351(17)30508-X [pii]
AID - 10.1016/j.envres.2017.08.035 [doi]
PST - ppublish
SO  - Environ Res. 2017 Nov;159:458-465. doi: 10.1016/j.envres.2017.08.035. Epub 2017 
      Sep 18.