PMID- 28859286
OWN - NLM
STAT- MEDLINE
DCOM- 20180510
LR  - 20220316
IS  - 1529-7268 (Electronic)
IS  - 0006-3363 (Linking)
VI  - 97
IP  - 1
DP  - 2017 Jul 1
TI  - Persistence of risk factors associated with maternal cardiovascular disease 
      following aberrant inflammation in rat pregnancy.
PG  - 143-152
LID - 10.1093/biolre/iox072 [doi]
AB  - INTRODUCTION: Pre-eclampsia is associated with increased risk of subsequent 
      cardiovascular and metabolic disease in the affected mothers. While aberrant 
      inflammation contributes to the pathophysiology of pre-eclampsia, it is unclear 
      whether maternal inflammation contributes to the increased risk of disease. Here, 
      we determined the effect of aberrant inflammation in pregnancy on cardiovascular 
      and metabolic disease risk factors. METHODS: Wistar rats were administered low 
      doses of lipopolysaccharide (LPS) on gestational days (GD) 13.5-16.5 to induce 
      inflammation. Controls included pregnant rats treated with saline and nonpregnant 
      rats treated with LPS or saline. We previously showed that LPS-treated pregnant 
      rats exhibit key features of pre-eclampsia. Echocardiographic parameters, heart 
      weight, blood pressure, blood lipids, pulse-wave velocity, and glucose tolerance, 
      were assessed at 16 weeks postpartum. Messenger RNA levels of transcription 
      factors associated with cardiac growth were measured in left ventricular tissue; 
      histone modifications and global DNA methylation were determined in hearts and 
      livers at GD 17.5 and at 16 weeks postpartum. RESULTS: Compared with 
      saline-treated pregnant rats and nonpregnant rats treated with LPS or saline, 
      LPS-treated pregnant rats exhibited left ventricular hypertrophy and increased 
      blood cholesterol and low-density lipoprotein levels at 16 weeks postdelivery. 
      LPS-treated rats had increased left ventricular mRNA levels of 
      hypertrophy-associated transcription factors at GD 17.5 and increased levels of 
      modified histones in hearts and livers at GD 17.5 and 16 weeks postpartum. Other 
      parameters remained unchanged. CONCLUSION: Aberrant inflammation during pregnancy 
      results in persistent alterations in maternal physiological parameters and 
      epigenetic modifications that could contribute to the pathophysiology of 
      cardiovascular disease.
CI  - (c) The Authors 2017. Published by Oxford University Press on behalf of Society for 
      the Study of Reproduction. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com
FAU - Ushida, Takafumi
AU  - Ushida T
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      Ontario, Canada.
AD  - Department of Gynecology and Obstetrics, Nagoya University Graduate School of 
      Medicine, Showa-ku, Nagoya, Japan.
FAU - Macdonald-Goodfellow, Shannyn K
AU  - Macdonald-Goodfellow SK
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      Ontario, Canada.
FAU - Quadri, Allegra
AU  - Quadri A
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      Ontario, Canada.
FAU - Tse, M Yat
AU  - Tse MY
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      Ontario, Canada.
FAU - Winn, Louise M
AU  - Winn LM
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      Ontario, Canada.
FAU - Pang, Stephen C
AU  - Pang SC
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      Ontario, Canada.
FAU - Adams, Michael A
AU  - Adams MA
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      Ontario, Canada.
FAU - Kotani, Tomomi
AU  - Kotani T
AD  - Department of Gynecology and Obstetrics, Nagoya University Graduate School of 
      Medicine, Showa-ku, Nagoya, Japan.
FAU - Kikkawa, Fumitaka
AU  - Kikkawa F
AD  - Department of Gynecology and Obstetrics, Nagoya University Graduate School of 
      Medicine, Showa-ku, Nagoya, Japan.
FAU - Graham, Charles H
AU  - Graham CH
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      Ontario, Canada.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biol Reprod
JT  - Biology of reproduction
JID - 0207224
RN  - 0 (Histones)
RN  - 0 (Lipopolysaccharides)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Blood Pressure
MH  - DNA/genetics/metabolism
MH  - Echocardiography
MH  - Female
MH  - Gene Expression Regulation
MH  - Heart
MH  - Histones/genetics/metabolism
MH  - Inflammation/*chemically induced/complications
MH  - Lipopolysaccharides/*toxicity
MH  - Pregnancy
MH  - *Pregnancy Complications, Cardiovascular
MH  - Rats
MH  - Rats, Wistar
MH  - Risk Factors
OTO - NOTNLM
OT  - cardiac hypertrophy
OT  - cardiovascular disease
OT  - epigenetics
OT  - hyperlipidemia
OT  - intrauterine growth restriction
OT  - maternal inflammation
OT  - pre-eclampsia
EDAT- 2017/09/02 06:00
MHDA- 2018/05/11 06:00
CRDT- 2017/09/02 06:00
PHST- 2017/04/19 00:00 [received]
PHST- 2017/07/04 00:00 [accepted]
PHST- 2017/09/02 06:00 [entrez]
PHST- 2017/09/02 06:00 [pubmed]
PHST- 2018/05/11 06:00 [medline]
AID - 3950272 [pii]
AID - 10.1093/biolre/iox072 [doi]
PST - ppublish
SO  - Biol Reprod. 2017 Jul 1;97(1):143-152. doi: 10.1093/biolre/iox072.