PMID- 28859357
OWN - NLM
STAT- MEDLINE
DCOM- 20180525
LR  - 20200306
IS  - 1442-2050 (Electronic)
IS  - 1120-8694 (Print)
IS  - 1120-8694 (Linking)
VI  - 30
IP  - 9
DP  - 2017 Sep 1
TI  - Review of antireflux procedures for proton pump inhibitor nonresponsive 
      gastroesophageal reflux disease.
PG  - 1-14
LID - 10.1093/dote/dox054 [doi]
AB  - Up to 40% of patients with gastroesophageal reflux disease (GERD) report 
      persistent symptoms despite proton pump inhibitor (PPI) therapy. This review 
      outlines the evidence for surgical and endoscopic therapies for the treatment of 
      PPI nonresponsive GERD. A literature search for GERD therapies from 2005 to 2015 
      in PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and the 
      Cochrane Database of Systematic Reviews identified 2928 unique citations. Of 
      those, 45 unique articles specific to surgical and endoscopic therapies for PPI 
      nonresponsive GERD were reviewed. Laparoscopic fundoplication (n = 19) provides 
      symptomatic and physiologic relief out to 10 years, though efficacy wanes with 
      time. Magnetic sphincter augmentation (n = 6) and transoral incisionless 
      fundoplication (n = 9) improve symptoms in PPI nonresponders and may offer fewer 
      side effects than fundoplication, though long-term follow-up is lacking. 
      Radiofrequency energy delivery (n = 8) has insufficient evidence for routine use 
      in treating PPI nonresponsive GERD. Electrical stimulator implantation (n = 1) 
      and endoscopic mucosal surgery (n = 2) are newer therapies under evaluation for 
      the treatment of GERD. Laparoscopic fundoplication remains the most proven 
      therapeutic approach. Newer antireflux procedures such as magnetic sphincter 
      augmentation and transoral incisionless fundoplication offer alternatives with 
      varying degrees of success, durability, and side effect profiles that may better 
      suit individual patients. Larger head-to-head comparison trials are needed to 
      better characterize the difference in symptom response and side effect profiles.
CI  - (c) The Authors 2017. Published by Oxford University Press on behalf of 
      International Society for Diseases of the Esophagus. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Hillman, L
AU  - Hillman L
AD  - Department of Medicine, Northwestern University Feinberg School of Medicine, 
      Chicago, IL, United States.
FAU - Yadlapati, R
AU  - Yadlapati R
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Northwestern 
      University Feinberg School of Medicine, Chicago, IL, United States.
FAU - Whitsett, M
AU  - Whitsett M
AD  - Department of Medicine, Northwestern University Feinberg School of Medicine, 
      Chicago, IL, United States.
FAU - Thuluvath, A J
AU  - Thuluvath AJ
AD  - Department of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, 
      Maryland, USA.
FAU - Berendsen, M A
AU  - Berendsen MA
AD  - Galter Health Sciences Library, Northwestern University Feinberg School of 
      Medicine, Chicago, Illinois.
FAU - Pandolfino, J E
AU  - Pandolfino JE
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Northwestern 
      University Feinberg School of Medicine, Chicago, IL, United States.
LA  - eng
GR  - R01 DK092217/DK/NIDDK NIH HHS/United States
GR  - T32 DK101363/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Dis Esophagus
JT  - Diseases of the esophagus : official journal of the International Society for 
      Diseases of the Esophagus
JID - 8809160
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Fundoplication/*methods
MH  - Gastroesophageal Reflux/drug therapy/*therapy
MH  - Humans
MH  - Laparoscopy
MH  - Magnets
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Radiofrequency Therapy
MH  - Retreatment
MH  - Treatment Failure
PMC - PMC5789775
MID - NIHMS933487
OTO - NOTNLM
OT  - fundoplication
OT  - lower esophageal sphincter
OT  - refractory gastroesophageal reflux disease
EDAT- 2017/09/02 06:00
MHDA- 2018/05/26 06:00
PMCR- 2018/07/19
CRDT- 2017/09/02 06:00
PHST- 2017/02/28 00:00 [received]
PHST- 2017/04/20 00:00 [accepted]
PHST- 2017/09/02 06:00 [entrez]
PHST- 2017/09/02 06:00 [pubmed]
PHST- 2018/05/26 06:00 [medline]
PHST- 2018/07/19 00:00 [pmc-release]
AID - 3979115 [pii]
AID - dox054 [pii]
AID - 10.1093/dote/dox054 [doi]
PST - ppublish
SO  - Dis Esophagus. 2017 Sep 1;30(9):1-14. doi: 10.1093/dote/dox054.