PMID- 28860098
OWN - NLM
STAT- MEDLINE
DCOM- 20180126
LR  - 20180209
IS  - 1872-7492 (Electronic)
IS  - 0168-1702 (Linking)
VI  - 240
DP  - 2017 Aug 15
TI  - Monocyte chemoattractant protein 1 released from macrophages induced by hepatitis 
      C virus promotes monocytes migration.
PG  - 190-196
LID - S0168-1702(17)30380-5 [pii]
LID - 10.1016/j.virusres.2017.08.013 [doi]
AB  - Hepatitis C Virus (HCV) infection usually progress to chronic liver disease and 
      shows a significant increase in total monocyte/macrophages numbers in the liver. 
      Monocyte chemoattractant protein-1 (MCP-1) plays a role in the recruitment of 
      monocytes to the liver. In this study we found that MCP-1 were up-regulated in 
      macrophages cultured with cell-culture derived infectious HCV particles (HCVcc) 
      and promoted the migration of monocytes. IL1beta, IL6 and TNFalpha were factors that 
      induced MCP-1 expression, which were up-regulated in macrophages induced by HCV. 
      Long-term of HCV incubation induced apoptosis of macrophages. Finally, we 
      observed the effect of HCV infected macrophages on nearby liver cells. Huh7 cells 
      continuously co-cultured with monocyte/macrophages displayed increased expression 
      of pro-inflammatory cytokines and the morphology of Huh7 cells were greatly 
      changed. Taken together, our study provides more information for the role of 
      monocyte/macrophages in HCV related chronic liver disease.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Liu, Yuan
AU  - Liu Y
AD  - Clinical laboratory, General Hospital of Chengdu Military Region of PLA, Chengdu, 
      China. Electronic address: 3502005006@smmu.edu.cn.
FAU - Wang, Wenbo
AU  - Wang W
AD  - Center for Disease Control and Prevention of Chengdu Military Region, Chengdu, 
      China.
FAU - Zou, Ziying
AU  - Zou Z
AD  - Clinical laboratory, General Hospital of Chengdu Military Region of PLA, Chengdu, 
      China.
FAU - Fan, Quanshui
AU  - Fan Q
AD  - Center for Disease Control and Prevention of Chengdu Military Region, Chengdu, 
      China.
FAU - Hu, Zonghai
AU  - Hu Z
AD  - Clinical laboratory, General Hospital of Chengdu Military Region of PLA, Chengdu, 
      China.
FAU - Feng, Ziliang
AU  - Feng Z
AD  - Center for Disease Control and Prevention of Chengdu Military Region, Chengdu, 
      China.
FAU - Zhu, Bing
AU  - Zhu B
AD  - Clinical laboratory, General Hospital of Chengdu Military Region of PLA, Chengdu, 
      China.
FAU - Xiong, Jie
AU  - Xiong J
AD  - Clinical laboratory, General Hospital of Chengdu Military Region of PLA, Chengdu, 
      China. Electronic address: xiongjie1969@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170830
PL  - Netherlands
TA  - Virus Res
JT  - Virus research
JID - 8410979
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - *Cell Movement
MH  - Chemokine CCL2/genetics/*metabolism
MH  - Hepacivirus/genetics/*physiology
MH  - Hepatitis C/metabolism/*physiopathology/virology
MH  - Hepatocytes/cytology/metabolism
MH  - Humans
MH  - Macrophages/*metabolism
MH  - Monocytes/*cytology/metabolism
OTO - NOTNLM
OT  - Cell migration
OT  - Hepatitis C virus
OT  - Infiltration
OT  - Macrophage
OT  - Monocyte chemoattractant protein 1
EDAT- 2017/09/02 06:00
MHDA- 2018/01/27 06:00
CRDT- 2017/09/02 06:00
PHST- 2017/05/19 00:00 [received]
PHST- 2017/08/27 00:00 [revised]
PHST- 2017/08/27 00:00 [accepted]
PHST- 2017/09/02 06:00 [pubmed]
PHST- 2018/01/27 06:00 [medline]
PHST- 2017/09/02 06:00 [entrez]
AID - S0168-1702(17)30380-5 [pii]
AID - 10.1016/j.virusres.2017.08.013 [doi]
PST - ppublish
SO  - Virus Res. 2017 Aug 15;240:190-196. doi: 10.1016/j.virusres.2017.08.013. Epub 
      2017 Aug 30.