PMID- 28860337
OWN - NLM
STAT- MEDLINE
DCOM- 20171010
LR  - 20190610
IS  - 1470-8728 (Electronic)
IS  - 0264-6021 (Linking)
VI  - 474
IP  - 18
DP  - 2017 Aug 30
TI  - From B to A: making an essential cofactor in a human parasite.
PG  - 3089-3092
LID - 10.1042/BCJ20170446 [doi]
AB  - Trypanosomatids are parasitic eukaryotic organisms that cause human disease. 
      These organisms have complex lifestyles; cycling between vertebrate and insect 
      hosts and alternating between two morphologies; a replicating form and an 
      infective, nonreplicating one. Because trypanosomatids are one of the few 
      organisms that do not synthesize the essential cofactor, heme, these parasites 
      sequester the most common form, heme B, from their hosts. Once acquired, the 
      parasites derivatize heme B to heme A by two sequential enzyme reactions. 
      Although heme C is found in many cytochrome c and c1 proteins, heme A is the 
      cofactor of only one known protein, cytochrome c oxidase (CcO). In a recent issue 
      of the Biochemical Journal, Merli et al. [Biochem. J. (2017) 474, 2315-2332] 
      demonstrate that the final step in the synthesis of heme A by heme A synthase 
      (TcCox15) and the subsequent activity of CcO are essential for infectivity and 
      replication of Trypanosoma cruzi.
CI  - (c) 2017 The Author(s). Published by Portland Press Limited on behalf of the 
      Biochemical Society.
FAU - Morrissette, Naomi S
AU  - Morrissette NS
AD  - Departments of Molecular Biology and Biochemistry, University of California 
      Irvine, Irvine, CA 92697, U.S.A.
FAU - Goulding, Celia W
AU  - Goulding CW
AD  - Departments of Molecular Biology and Biochemistry, University of California 
      Irvine, Irvine, CA 92697, U.S.A. celia.goulding@uci.edu.
AD  - Pharmaceutical Sciences, University of California Irvine, Irvine, CA 92697, 
      U.S.A.
LA  - eng
GR  - R01 AI081161/AI/NIAID NIH HHS/United States
PT  - Comment
PT  - Journal Article
DEP - 20170830
PL  - England
TA  - Biochem J
JT  - The Biochemical journal
JID - 2984726R
RN  - 42VZT0U6YR (Heme)
RN  - 9007-43-6 (Cytochromes c)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
SB  - IM
CON - Biochem J. 2017 Jun 27;474(14 ):2315-2332. PMID: 28588043
MH  - Animals
MH  - Cytochromes c
MH  - Electron Transport Complex IV
MH  - Heme/*chemistry
MH  - Humans
MH  - *Parasites
MH  - Trypanosoma cruzi
EDAT- 2017/09/02 06:00
MHDA- 2017/10/11 06:00
CRDT- 2017/09/02 06:00
PHST- 2017/07/08 00:00 [received]
PHST- 2017/08/02 00:00 [revised]
PHST- 2017/08/03 00:00 [accepted]
PHST- 2017/09/02 06:00 [entrez]
PHST- 2017/09/02 06:00 [pubmed]
PHST- 2017/10/11 06:00 [medline]
AID - BCJ20170446 [pii]
AID - 10.1042/BCJ20170446 [doi]
PST - epublish
SO  - Biochem J. 2017 Aug 30;474(18):3089-3092. doi: 10.1042/BCJ20170446.