PMID- 28860463
OWN - NLM
STAT- MEDLINE
DCOM- 20190611
LR  - 20190613
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Aug 31
TI  - Decision-making in primary onset middle-age type 2 diabetes mellitus: a BOLD-fMRI 
      study.
PG  - 10246
LID - 10.1038/s41598-017-10228-x [doi]
LID - 10246
AB  - Although type 2 diabetes mellitus (T2DM) is a well-recognized risk factor for 
      dementia, the neural mechanisms that underlying cognitive impairment in T2DM 
      remain unclear. We used functional magnetic resonance imaging (fMRI) during a 
      computerized version of the Iowa Gambling Task to investigate the neural basis of 
      decision making at the initial onset stage of T2DM. Eighteen newly diagnosed 
      middle-aged T2DM patients, with no previous diabetic treatment history, and 18 
      matched controls were recruited. Results indicated that T2DM patients made more 
      disadvantageous decisions than controls. Compared to healthy subjects, T2DM 
      patients showed decreased activation in the ventral medial prefrontal cortex 
      (VMPFC), orbitofrontal cortex (OFC) and anterior cingulate cortex, and increased 
      activity in the dorsolateral prefrontal cortex, posterior cingulate cortex, 
      insula and occipital lobes. IGT performance positively correlated with changes in 
      brain activation in the VMPFC and OFC in both groups. Moreover, poor glycemic 
      control was associated with decision-making function both in behavioral and brain 
      activity in the VMPFC and OFC in patients. Conclusively, T2DM patients may suffer 
      from weaknesses in their prefrontal cortex functions that lead to poorer 
      decision-making under ambiguity, at least as assessed by the IGT.
FAU - Sun, Dan-Miao
AU  - Sun DM
AD  - The First Affiliated Hospital of Shantou University Medical College, Shantou, 
      Guangdong Province, 515041, China.
AD  - Guang dong Key Laboratory of Medical Molecular Imaging, 515041, Shantou, China.
FAU - Ma, Ye
AU  - Ma Y
AD  - Graduate School of Beijing Normal University, 519087, Zhuhai, China.
FAU - Sun, Zong-Bo
AU  - Sun ZB
AD  - The First Affiliated Hospital of Shantou University Medical College, Shantou, 
      Guangdong Province, 515041, China.
AD  - Guang dong Key Laboratory of Medical Molecular Imaging, 515041, Shantou, China.
FAU - Xie, Lei
AU  - Xie L
AD  - The First Affiliated Hospital of Shantou University Medical College, Shantou, 
      Guangdong Province, 515041, China.
AD  - Guang dong Key Laboratory of Medical Molecular Imaging, 515041, Shantou, China.
FAU - Huang, Jin-Zhuang
AU  - Huang JZ
AD  - The First Affiliated Hospital of Shantou University Medical College, Shantou, 
      Guangdong Province, 515041, China.
AD  - Guang dong Key Laboratory of Medical Molecular Imaging, 515041, Shantou, China.
FAU - Chen, Wei-Song
AU  - Chen WS
AD  - The First Affiliated Hospital of Shantou University Medical College, Shantou, 
      Guangdong Province, 515041, China.
FAU - Duan, Shou-Xing
AU  - Duan SX
AD  - The First Affiliated Hospital of Shantou University Medical College, Shantou, 
      Guangdong Province, 515041, China.
AD  - Guang dong Key Laboratory of Medical Molecular Imaging, 515041, Shantou, China.
FAU - Lin, Zhi-Rong
AU  - Lin ZR
AD  - The First Affiliated Hospital of Shantou University Medical College, Shantou, 
      Guangdong Province, 515041, China.
FAU - Guo, Rui-Wei
AU  - Guo RW
AD  - The First Affiliated Hospital of Shantou University Medical College, Shantou, 
      Guangdong Province, 515041, China.
AD  - Guang dong Key Laboratory of Medical Molecular Imaging, 515041, Shantou, China.
FAU - Le, Hong-Bo
AU  - Le HB
AD  - The First Affiliated Hospital of Shantou University Medical College, Shantou, 
      Guangdong Province, 515041, China.
AD  - Guang dong Key Laboratory of Medical Molecular Imaging, 515041, Shantou, China.
FAU - Xu, Wen-Can
AU  - Xu WC
AD  - The First Affiliated Hospital of Shantou University Medical College, Shantou, 
      Guangdong Province, 515041, China.
FAU - Ma, Shu-Hua
AU  - Ma SH
AD  - The First Affiliated Hospital of Shantou University Medical College, Shantou, 
      Guangdong Province, 515041, China. carina_king@163.com.
AD  - Guang dong Key Laboratory of Medical Molecular Imaging, 515041, Shantou, China. 
      carina_king@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170831
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Brain Mapping
MH  - Case-Control Studies
MH  - Cerebral Cortex/diagnostic imaging/physiopathology
MH  - Decision Making/*physiology
MH  - Diabetes Mellitus, Type 2/diagnostic imaging/*psychology
MH  - Female
MH  - Gyrus Cinguli/diagnostic imaging/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Prefrontal Cortex/diagnostic imaging/*physiopathology
PMC - PMC5579021
COIS- The authors declare that they have no competing interests.
EDAT- 2017/09/02 06:00
MHDA- 2019/06/14 06:00
PMCR- 2017/08/31
CRDT- 2017/09/02 06:00
PHST- 2016/12/19 00:00 [received]
PHST- 2017/08/02 00:00 [accepted]
PHST- 2017/09/02 06:00 [entrez]
PHST- 2017/09/02 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2017/08/31 00:00 [pmc-release]
AID - 10.1038/s41598-017-10228-x [pii]
AID - 10228 [pii]
AID - 10.1038/s41598-017-10228-x [doi]
PST - epublish
SO  - Sci Rep. 2017 Aug 31;7(1):10246. doi: 10.1038/s41598-017-10228-x.