PMID- 28860746
OWN - NLM
STAT- MEDLINE
DCOM- 20171218
LR  - 20181202
IS  - 1178-2013 (Electronic)
IS  - 1176-9114 (Print)
IS  - 1176-9114 (Linking)
VI  - 12
DP  - 2017
TI  - Highly sensitive voltamperometric determination of pyritinol using carbon 
      nanofiber/gold nanoparticle composite screen-printed carbon electrode.
PG  - 5177-5188
LID - 10.2147/IJN.S138978 [doi]
AB  - A novel and highly sensitive electrochemical method for the detection of 
      pyritinol in pharmaceutical products and serum samples has been accomplished 
      based on voltamperometric response of pyritinol in carbon nanofiber-gold 
      nanoparticle (CNF-GNP)-modified screen-printed carbon electrode (SPCE). The 
      electrochemical response of pyritinol to CNF-GNP-modified SPCE was studied by 
      cyclic voltammetry and square-wave voltammetry (SWV). Under optimized working 
      conditions, the novel sensor shows excellent voltamperometric response toward 
      pyritinol. The SWV study shows significantly enhanced electrochemical response 
      for pyritinol in CNF-GNP-modified SPCE providing high sensitivity to the novel 
      sensor for pyritinol detection. The peak current for pyritinol is found to be 
      linear with the concentration in the range 1.0x10(-8)-5.0x10(-5) M with a 
      detection limit of 6.23x10(-9) M using SWV as the detection method. The viability 
      of the new developed sensor for the analytical purposes was studied by performing 
      experiments on various commercial pharmaceutical products and blood serum 
      samples, which yielded adequate recoveries of pyritinol. The novel 
      electrochemical sensor provides high sensitivity, enhanced selectivity, good 
      reproducibility and practical applicability.
FAU - Apetrei, Irina Mirela
AU  - Apetrei IM
AD  - Department of Pharmaceutical Sciences, Medical and Pharmaceutical Research 
      Center, Faculty of Medicine and Pharmacy.
FAU - Apetrei, Constantin
AU  - Apetrei C
AD  - Department of Chemistry, Physics and Environment, Faculty of Sciences and 
      Environment, "Dunarea de Jos" University of Galati, Galati, Romania.
LA  - eng
PT  - Journal Article
DEP - 20170721
PL  - New Zealand
TA  - Int J Nanomedicine
JT  - International journal of nanomedicine
JID - 101263847
RN  - 7440-44-0 (Carbon)
RN  - 7440-57-5 (Gold)
RN  - AK5Q5FZH2R (Pyrithioxin)
SB  - IM
MH  - Carbon/chemistry
MH  - Electrochemical Techniques/instrumentation/*methods
MH  - *Electrodes
MH  - Equipment Design
MH  - Gold/chemistry
MH  - Limit of Detection
MH  - Nanofibers/*chemistry
MH  - Nanoparticles/*chemistry
MH  - Pyrithioxin/*analysis/blood
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
PMC - PMC5560415
OTO - NOTNLM
OT  - carbon nanofiber
OT  - gold nanoparticle
OT  - pyritinol
OT  - sensor
OT  - square-wave voltammetry
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2017/09/02 06:00
MHDA- 2017/12/19 06:00
PMCR- 2017/07/21
CRDT- 2017/09/02 06:00
PHST- 2017/09/02 06:00 [entrez]
PHST- 2017/09/02 06:00 [pubmed]
PHST- 2017/12/19 06:00 [medline]
PHST- 2017/07/21 00:00 [pmc-release]
AID - ijn-12-5177 [pii]
AID - 10.2147/IJN.S138978 [doi]
PST - epublish
SO  - Int J Nanomedicine. 2017 Jul 21;12:5177-5188. doi: 10.2147/IJN.S138978. 
      eCollection 2017.