PMID- 28860941
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1426-3912 (Print)
IS  - 1644-4124 (Electronic)
IS  - 1426-3912 (Linking)
VI  - 42
IP  - 2
DP  - 2017
TI  - Dengue virus and Japanese encephalitis virus infection of the central nervous 
      system share similar profiles of cytokine accumulation in cerebrospinal fluid.
PG  - 218-222
LID - 10.5114/ceji.2017.69366 [doi]
AB  - Dengue virus (DENV) and Japanese encephalitis virus (JEV) are two important 
      pathogenic viruses that can cause severe encephalitis, which is accompanied by 
      inflammatory cytokines. However, the inflammatory cytokine content of 
      cerebrospinal fluid (CSF) in DENV and JEV infection of central nervous system are 
      not sufficiently studied. To investigate cytokine levels in serum and CSF of 
      hospitalised children with DENV and JEV infection of the central nervous system, 
      a total of 183 hospitalised children with viral encephalitis-like syndrome were 
      enrolled between May 2014 and April 2015 at the Children's Hospital of Chenzhou, 
      Hunan, China. DENV and JEV infection was diagnosed by ELISA. Cytokine levels in 
      the serum and CSF were measured by commercial ELISA kits. Twenty-nine (15.85%) 
      and 26 (14.21%) DENV and JEV infections were detected in 183 patients with viral 
      encephalitis-like syndrome, respectively. Higher granulocyte-macrophage 
      colony-stimulating factor (GM-CSF) levels were detected in the serum of JEV 
      infected patients than in DNEV patients (p < 0.05) or in healthy controls (p < 
      0.001), and levels of GM-CSF, interleukin 6 (IL-6) and monocyte chemoattractant 
      protein-1 (MCP-1) were higher in the CSF than serum in both DENV and JEV 
      infection. Both DENV and JEV infection induced similar cytokine accumulation 
      profiles in the CSF, which probably contributed to DENV- and JEV-induced 
      immunopathogenesis.
FAU - Li, Haipeng
AU  - Li H
AD  - Translational Medicine Institute, The First People's Hospital of Chenzhou, 
      University of South China, Chenzhou, Hunan, China.
AD  - These authors made egnal contributions.
FAU - Li, Yuanyuan
AU  - Li Y
AD  - Translational Medicine Institute, The First People's Hospital of Chenzhou, 
      University of South China, Chenzhou, Hunan, China.
AD  - Department of Neurology, The Third People's Hosptial of Yancheng, Yancheng, 
      Jiangsu, China.
AD  - These authors made egnal contributions.
FAU - Wen, Bo
AU  - Wen B
AD  - Translational Medicine Institute, The First People's Hospital of Chenzhou, 
      University of South China, Chenzhou, Hunan, China.
AD  - These authors made egnal contributions.
FAU - Zhang, Jian
AU  - Zhang J
AD  - Translational Medicine Institute, The First People's Hospital of Chenzhou, 
      University of South China, Chenzhou, Hunan, China.
FAU - Wang, Chengwu
AU  - Wang C
AD  - Translational Medicine Institute, The First People's Hospital of Chenzhou, 
      University of South China, Chenzhou, Hunan, China.
FAU - Song, Zhanyi
AU  - Song Z
AD  - Translational Medicine Institute, The First People's Hospital of Chenzhou, 
      University of South China, Chenzhou, Hunan, China.
FAU - Li, Shuochi
AU  - Li S
AD  - Translational Medicine Institute, The First People's Hospital of Chenzhou, 
      University of South China, Chenzhou, Hunan, China.
FAU - Qu, Xiaowang
AU  - Qu X
AD  - Translational Medicine Institute, The First People's Hospital of Chenzhou, 
      University of South China, Chenzhou, Hunan, China.
FAU - Huang, Renbin
AU  - Huang R
AD  - Translational Medicine Institute, The First People's Hospital of Chenzhou, 
      University of South China, Chenzhou, Hunan, China.
FAU - Liu, Wenpei
AU  - Liu W
AD  - Translational Medicine Institute, The First People's Hospital of Chenzhou, 
      University of South China, Chenzhou, Hunan, China.
AD  - These authors made egnal contributions.
LA  - eng
PT  - Journal Article
DEP - 20170808
PL  - Poland
TA  - Cent Eur J Immunol
JT  - Central-European journal of immunology
JID - 9702239
PMC - PMC5573897
OTO - NOTNLM
OT  - Japanese encephalitis virus
OT  - central nervous system
OT  - cytokine
OT  - dengue virus
COIS- The authors declare no conflict of interest.
EDAT- 2017/09/02 06:00
MHDA- 2017/09/02 06:01
PMCR- 2017/01/01
CRDT- 2017/09/02 06:00
PHST- 2016/08/29 00:00 [received]
PHST- 2016/09/06 00:00 [accepted]
PHST- 2017/09/02 06:00 [entrez]
PHST- 2017/09/02 06:00 [pubmed]
PHST- 2017/09/02 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 30451 [pii]
AID - 10.5114/ceji.2017.69366 [doi]
PST - ppublish
SO  - Cent Eur J Immunol. 2017;42(2):218-222. doi: 10.5114/ceji.2017.69366. Epub 2017 
      Aug 8.