PMID- 28861029
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 8
DP  - 2017
TI  - Repeatability and Reproducibility of Retinal Neuronal and Axonal Measures on 
      Spectral-Domain Optical Coherence Tomography in Patients with Cognitive 
      Impairment.
PG  - 359
LID - 10.3389/fneur.2017.00359 [doi]
LID - 359
AB  - BACKGROUND: With increasing interest in determining if measurement of retinal 
      neuronal structure with spectral-domain optical coherence tomography (SD-OCT) is 
      useful in accessing neurodegenerative process in cognitive decline and 
      development of dementia, it is important to evaluate whether the SD-OCT 
      measurements are repeatable and reproducible in these patients. METHODS: This is 
      a retrospective cohort study. Patients with Alzheimer's disease (AD) or mild 
      cognitive impairment (MCI) with no change in global clinical dementia rating 
      (CDR) score at 1-year follow-up were eligible to be included. Ganglion cell-inner 
      plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL) parameters were 
      measured with SD-OCT at baseline, 6-month, and 1-year follow-up visits. At 
      baseline, SD-OCT scans were repeated to access intra-visit repeatability of the 
      SD-OCT measurement. SD-OCT measurement over three visits was used to access 
      inter-visit reproducibility. We calculated intraclass correlation coefficients 
      (ICC) and coefficients of variation (CoVs). RESULTS: We included 32 patients with 
      stable AD and 29 patients with stable MCI in the final analysis. For GC-IPL 
      measures, the average intra-visit ICC was 0.969 (range: 0.948-0.985), and CoV was 
      1.81% (range: 1.14-2.40); while the average inter-visit ICC was 0.968 
      (0.941-0.985), and CoV was 1.91% (range: 1.24-2.32). The average ICC and CoV of 
      intra-visit RNFL measured were 0.965 (range: 0.937-0.986) and 2.32% (range: 
      1.34-2.90%), respectively. The average ICC and CoV of inter-visit RNFL measures 
      were 0.927 (range: 0.845-0.961) and 3.83% (range: 2.71-5.25%), respectively. 
      CONCLUSION: Both GC-IPL and RNFL measurements had good intra-visit repeatability 
      and inter-visit reproducibility over 1 year in elderly patients with no decline 
      in cognitive function, suggesting that SD-OCT is a reliable tool to assess 
      neurodegenerative process over time.
FAU - Loh, Edwin Hong-Teck
AU  - Loh EH
AD  - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 
      Singapore.
FAU - Ong, Yi-Ting
AU  - Ong YT
AD  - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 
      Singapore.
AD  - Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.
FAU - Venketasubramanian, Narayanaswamy
AU  - Venketasubramanian N
AD  - Memory Aging and Cognition Centre, National University Health System, Singapore, 
      Singapore.
AD  - Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore.
FAU - Hilal, Saima
AU  - Hilal S
AD  - Memory Aging and Cognition Centre, National University Health System, Singapore, 
      Singapore.
FAU - Thet, Naing
AU  - Thet N
AD  - Department of Ophthalmology, Yong Loo Lin School of Medicine, National University 
      of Singapore, Singapore, Singapore.
FAU - Wong, Tien Yin
AU  - Wong TY
AD  - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 
      Singapore.
AD  - Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.
AD  - Department of Ophthalmology, Yong Loo Lin School of Medicine, National University 
      of Singapore, Singapore, Singapore.
FAU - Chen, Christopher P L
AU  - Chen CPL
AD  - Memory Aging and Cognition Centre, National University Health System, Singapore, 
      Singapore.
AD  - Department of Pharmacology, National University of Singapore, Singapore, 
      Singapore.
FAU - Cheung, Carol Yim-Lui
AU  - Cheung CY
AD  - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 
      Singapore.
AD  - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong 
      Kong, Hong Kong, Hong Kong.
LA  - eng
PT  - Journal Article
DEP - 20170815
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC5559462
OTO - NOTNLM
OT  - dementia
OT  - mild cognitive impairment
OT  - optical coherence tomography
OT  - repeatability
OT  - reproducibility
OT  - retina
EDAT- 2017/09/02 06:00
MHDA- 2017/09/02 06:01
PMCR- 2017/08/15
CRDT- 2017/09/02 06:00
PHST- 2017/04/18 00:00 [received]
PHST- 2017/07/07 00:00 [accepted]
PHST- 2017/09/02 06:00 [entrez]
PHST- 2017/09/02 06:00 [pubmed]
PHST- 2017/09/02 06:01 [medline]
PHST- 2017/08/15 00:00 [pmc-release]
AID - 10.3389/fneur.2017.00359 [doi]
PST - epublish
SO  - Front Neurol. 2017 Aug 15;8:359. doi: 10.3389/fneur.2017.00359. eCollection 2017.