PMID- 28861601
OWN - NLM
STAT- MEDLINE
DCOM- 20180515
LR  - 20190221
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 274
IP  - 11
DP  - 2017 Nov
TI  - The role of high-risk human papillomavirus infections in laryngeal squamous cell 
      carcinoma.
PG  - 3837-3842
LID - 10.1007/s00405-017-4718-1 [doi]
AB  - The contribution of human papillomavirus (HPV) to the development and clinical 
      outcome of oropharyngeal cancers has been well documented. The association of HPV 
      in laryngeal squamous cell carcinoma (LSCC) has been examined in several studies, 
      but controversy exists regarding its role in carcinogenesis, the outcome of the 
      patients and thus, clinical significance of HPV testing in LSCC. In this review, 
      we give an update of known associations between HPV-positive testing and 
      carcinogenesis in laryngeal cancer. In an early study, the HPV-DNA detection rate 
      in LSCC was documented being 24.0% with significant regional differences. 
      Non-HPV-16 types were more often detected in LSCC when compared to the 
      oropharynx. Later, single institution case series revealed markedly fewer amounts 
      (<10%) of HPV DNA in LSCC and the results suggested that high-risk HPV infections 
      seem to be biologically irrelevant in most LSCC. The significance of p16INK4a 
      (p16) expression as a surrogate marker towards high-risk HPV infection and the 
      outcome in LSCC is doubtful, since only few p16-positive LSCC samples are HPV RNA 
      positive and accordingly there was poor correlation of p16-test results towards 
      the outcome in LSCC. Recent meta-analysis (n = 2739) and large case series 
      (n = 1042) of LSCC revealed the true rate of HPV-driven LSCC being 8.6%, 
      respectively, <5%. In the latter the rate of DNA-, DNA/RNA-, DNA/p16, and 
      DNA/RNA/p16 positivity was 5.7, 3.1, 1.9, and 1.5%, respectively. These results 
      indicate relevant amounts of insignificant/transient HPV infection in LSCC 
      specimen. However, in the same study the rate of transforming HPV infections 
      increased since 2000, and younger patients had higher amounts of HPV-driven LSCC. 
      Serologic testing of E6/E7 antibodies additionally revealed odds ratios between 2 
      and 5 as a hint for a weak contribution of high-risk HPV infection and the 
      development of LSCC. The contribution of HPV for the development of LSCC needs 
      future investigations, to date, routine HPV testing of LSCC specimen is not 
      warranted.
FAU - Wittekindt, Claus
AU  - Wittekindt C
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, University of Giessen, 
      Klinikstrasse 33, 35392, Giessen, Germany.
FAU - Wuerdemann, Nora
AU  - Wuerdemann N
AUID- ORCID: 0000-0002-1092-689X
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, University of Giessen, 
      Klinikstrasse 33, 35392, Giessen, Germany. 
      nora.wuerdemann@hno.med.uni-giessen.de.
FAU - Gattenlohner, Stefan
AU  - Gattenlohner S
AD  - Department of Pathology, University of Giessen, Giessen, Germany.
FAU - Brobeil, Alexander
AU  - Brobeil A
AD  - Department of Pathology, University of Giessen, Giessen, Germany.
FAU - Wierzbicka, Malgorzata
AU  - Wierzbicka M
AD  - Department of Otolaryngology and Laryngological Oncology, University of Medical 
      Sciences, Poznan, Poland.
FAU - Wagner, Steffen
AU  - Wagner S
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, University of Giessen, 
      Klinikstrasse 33, 35392, Giessen, Germany.
FAU - Klussmann, Jens Peter
AU  - Klussmann JP
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, University of Giessen, 
      Klinikstrasse 33, 35392, Giessen, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170831
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Carcinogenesis
MH  - Carcinoma, Squamous Cell/pathology/*virology
MH  - Head and Neck Neoplasms/pathology/*virology
MH  - Humans
MH  - Laryngeal Neoplasms/pathology/*virology
MH  - Papillomaviridae
MH  - Papillomavirus Infections/*pathology
MH  - Squamous Cell Carcinoma of Head and Neck
OTO - NOTNLM
OT  - HPV DNA
OT  - Human papillomavirus
OT  - Laryngeal squamous cell carcinoma
OT  - p16
EDAT- 2017/09/02 06:00
MHDA- 2018/05/16 06:00
CRDT- 2017/09/02 06:00
PHST- 2017/06/16 00:00 [received]
PHST- 2017/08/12 00:00 [accepted]
PHST- 2017/09/02 06:00 [pubmed]
PHST- 2018/05/16 06:00 [medline]
PHST- 2017/09/02 06:00 [entrez]
AID - 10.1007/s00405-017-4718-1 [pii]
AID - 10.1007/s00405-017-4718-1 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2017 Nov;274(11):3837-3842. doi: 
      10.1007/s00405-017-4718-1. Epub 2017 Aug 31.