PMID- 28862678
OWN - NLM
STAT- MEDLINE
DCOM- 20180514
LR  - 20181113
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 9
IP  - 9
DP  - 2017 Sep 1
TI  - Rosemary Extract as a Potential Anti-Hyperglycemic Agent: Current Evidence and 
      Future Perspectives.
LID - 10.3390/nu9090968 [doi]
LID - 968
AB  - Type 2 diabetes mellitus (T2DM), a disease on the rise and with huge economic 
      burden to health care systems around the globe, results from defects in insulin 
      action (termed insulin resistance) combined with impaired insulin secretion. 
      Current methods of prevention and treatments for insulin resistance and T2DM are 
      lacking in number and efficacy and, therefore, there is a need for new 
      preventative measures and targeted therapies. In recent years, chemicals found in 
      plants/herbs have attracted attention for their use as functional foods or 
      nutraceuticals for preventing and treating insulin resistance and T2DM. Rosemary 
      is an evergreen shrub indigenous to the Mediterranean region and South America, 
      which contains various polyphenols. Rosemary extract and its polyphenolic 
      constituents have been reported to have antioxidant, anti-inflammatory, 
      anticancer, and anti-hyperglycemic properties. The current review summarizes the 
      existing in vitro and in vivo studies examining the anti-diabetic effects of 
      rosemary extract and its polyphenolic components and highlights the known 
      mechanism of action.
FAU - Naimi, Madina
AU  - Naimi M
AD  - Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, 
      Canada. madinanaimi@gmail.com.
FAU - Vlavcheski, Filip
AU  - Vlavcheski F
AD  - Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, 
      Canada. fv11vi@brocku.ca.
FAU - Shamshoum, Hesham
AU  - Shamshoum H
AD  - Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, 
      Canada. hs12af@brocku.ca.
FAU - Tsiani, Evangelia
AU  - Tsiani E
AD  - Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, 
      Canada. ltsiani@brocku.ca.
AD  - Centre for Bone and Muscle Health, Brock University, St. Catharines, ON L2S 3A1, 
      Canada. ltsiani@brocku.ca.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170901
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Humans
MH  - Hyperglycemia/*drug therapy
MH  - Insulin Resistance
MH  - Plant Extracts/chemistry/*therapeutic use
MH  - Rosmarinus/*chemistry
PMC - PMC5622728
OTO - NOTNLM
OT  - carnosic acid
OT  - carnosol
OT  - diabetes
OT  - insulin resistance
OT  - rosemary extract
OT  - rosmarinic acid
COIS- The authors declare no conflict of interest.
EDAT- 2017/09/02 06:00
MHDA- 2018/05/15 06:00
PMCR- 2017/09/01
CRDT- 2017/09/02 06:00
PHST- 2017/08/15 00:00 [received]
PHST- 2017/08/28 00:00 [revised]
PHST- 2017/08/29 00:00 [accepted]
PHST- 2017/09/02 06:00 [entrez]
PHST- 2017/09/02 06:00 [pubmed]
PHST- 2018/05/15 06:00 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - nu9090968 [pii]
AID - nutrients-09-00968 [pii]
AID - 10.3390/nu9090968 [doi]
PST - epublish
SO  - Nutrients. 2017 Sep 1;9(9):968. doi: 10.3390/nu9090968.