PMID- 28862959
OWN - NLM
STAT- MEDLINE
DCOM- 20180509
LR  - 20181113
IS  - 2047-9980 (Electronic)
IS  - 2047-9980 (Linking)
VI  - 6
IP  - 8
DP  - 2017 Aug 21
TI  - Hypo-Attenuated Leaflet Thickening and Reduced Leaflet Motion in Sutureless 
      Bioprosthetic Aortic Valves.
LID - 10.1161/JAHA.116.005251 [doi]
LID - e005251
AB  - BACKGROUND: The prevalence of hypo-attenuated leaflet thickening (HALT) and 
      reduced leaflet motion (RLM) is unknown in surgically implanted bioprostheses 
      because systematic investigation of HALT and/or RLM is limited to a few 
      catheter-based valves. The aim of this study was to investigate the prevalence of 
      HALT and RLM by cardiac computed tomography in patients who underwent surgical 
      aortic valve replacement and received a Perceval sutureless aortic valve 
      bioprosthesis. METHODS AND RESULTS: This was a single-center prospective 
      observational study that included 47 patients (83.5% of the total number of 
      implantations) who underwent surgical aortic valve replacement with implantation 
      of the Perceval sutureless bioprosthesis (LivaNova PLC, London, UK) at Karolinska 
      University Hospital in Stockholm, Sweden from 2012 to 2016 and were studied by 
      cardiac computed tomography. Cardiac computed tomography was performed at a 
      median of 491 days (range 36-1247 days) postoperatively. HALT was found in 18 
      (38%) patients and RLM in 13 (28%) patients. All patients with RLM had HALT. 
      Among patients with HALT, 5 out of 18 patients (28%) were treated with 
      anticoagulation (warfarin or any novel oral anticoagulant) at the time of cardiac 
      computed tomography. Among patients with RLM, 3 out of 13 patients (23%) were 
      treated with anticoagulation. CONCLUSIONS: HALT and RLM were prevalent in the 
      surgically implanted Perceval sutureless aortic valve bioprosthesis. Both HALT 
      and RLM were found in patients with ongoing anticoagulation treatment. Whether 
      these findings are associated with adverse events needs further study. CLINICAL 
      TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: 
      NCT02671474.
CI  - (c) 2017 The Authors. Published on behalf of the American Heart Association, Inc., 
      by Wiley.
FAU - Dalen, Magnus
AU  - Dalen M
AD  - Department of Cardiothoracic Surgery and Anesthesiology, Karolinska University 
      Hospital, Stockholm, Sweden magnus.dalen@sll.se.
AD  - Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Sartipy, Ulrik
AU  - Sartipy U
AD  - Department of Cardiothoracic Surgery and Anesthesiology, Karolinska University 
      Hospital, Stockholm, Sweden.
AD  - Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Cederlund, Kerstin
AU  - Cederlund K
AD  - Department of Radiology Huddinge, Karolinska University Hospital, Stockholm, 
      Sweden.
AD  - Department of Clinical Science, Intervention and Technology, Karolinska 
      Institutet, Stockholm, Sweden.
FAU - Franco-Cereceda, Anders
AU  - Franco-Cereceda A
AD  - Department of Cardiothoracic Surgery and Anesthesiology, Karolinska University 
      Hospital, Stockholm, Sweden.
AD  - Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Svensson, Anders
AU  - Svensson A
AD  - Department of Radiology Huddinge, Karolinska University Hospital, Stockholm, 
      Sweden.
AD  - Department of Clinical Science, Intervention and Technology, Karolinska 
      Institutet, Stockholm, Sweden.
FAU - Themudo, Raquel
AU  - Themudo R
AD  - Department of Radiology Huddinge, Karolinska University Hospital, Stockholm, 
      Sweden.
AD  - Department of Clinical Physiology, Karolinska Institutet, Stockholm, Sweden.
FAU - Svenarud, Peter
AU  - Svenarud P
AD  - Department of Cardiothoracic Surgery and Anesthesiology, Karolinska University 
      Hospital, Stockholm, Sweden.
AD  - Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Bacsovics Brolin, Elin
AU  - Bacsovics Brolin E
AD  - Department of Radiology Huddinge, Karolinska University Hospital, Stockholm, 
      Sweden.
AD  - Department of Clinical Science, Intervention and Technology, Karolinska 
      Institutet, Stockholm, Sweden.
LA  - eng
SI  - ClinicalTrials.gov/NCT02671474
PT  - Journal Article
PT  - Observational Study
PT  - Video-Audio Media
DEP - 20170821
PL  - England
TA  - J Am Heart Assoc
JT  - Journal of the American Heart Association
JID - 101580524
RN  - 0 (Anticoagulants)
SB  - IM
CIN - J Am Heart Assoc. 2017 Aug 21;6(8):. PMID: 28862965
MH  - Administration, Oral
MH  - Adult
MH  - Aged
MH  - Anticoagulants/administration & dosage
MH  - Aortic Valve/diagnostic imaging/physiopathology/*surgery
MH  - Aortic Valve Stenosis/diagnostic imaging/epidemiology/physiopathology/*surgery
MH  - *Bioprosthesis
MH  - Female
MH  - *Heart Valve Prosthesis
MH  - Heart Valve Prosthesis Implantation/adverse effects/*instrumentation/*methods
MH  - Hospitals, University
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multidetector Computed Tomography
MH  - Postoperative Complications/diagnostic imaging/*epidemiology/physiopathology
MH  - Prevalence
MH  - Prospective Studies
MH  - Prosthesis Design
MH  - *Sutureless Surgical Procedures/adverse effects
MH  - Sweden/epidemiology
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC5586405
OTO - NOTNLM
OT  - aortic valve surgery
OT  - bioprosthesis
OT  - cardiac computed tomography
OT  - leaflet motion
OT  - leaflet thickening
EDAT- 2017/09/02 06:00
MHDA- 2018/05/10 06:00
PMCR- 2017/08/01
CRDT- 2017/09/02 06:00
PHST- 2017/09/02 06:00 [entrez]
PHST- 2017/09/02 06:00 [pubmed]
PHST- 2018/05/10 06:00 [medline]
PHST- 2017/08/01 00:00 [pmc-release]
AID - JAHA.116.005251 [pii]
AID - JAH32296 [pii]
AID - 10.1161/JAHA.116.005251 [doi]
PST - epublish
SO  - J Am Heart Assoc. 2017 Aug 21;6(8):e005251. doi: 10.1161/JAHA.116.005251.