PMID- 28863235
OWN - NLM
STAT- MEDLINE
DCOM- 20180702
LR  - 20180705
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 7
IP  - 11
DP  - 2017 Nov
TI  - Therapeutic potential of alpha-lipoic acid derivative, sodium zinc histidine 
      dithiooctanamide, in a mouse model of allergic rhinitis.
PG  - 1095-1103
LID - 10.1002/alr.22008 [doi]
AB  - BACKGROUND: Oxidative stress is involved in various diseases, including 
      allergies. Several studies have pointed to the preventive and therapeutic 
      potential of antioxidants in allergic disorders. However, little is known about 
      the immunomodulatory effects of antioxidants in type I hypersensitivity. In this 
      study we aimed to explore the impact of a water-soluble antioxidant and alpha-lipoic 
      acid derivative, sodium zinc histidine dithiooctanamide (DHL-HisZn), on 
      mast-cell- and T-cell-mediated allergic and immune responses both in vitro and in 
      vivo. METHODS: The therapeutic impact of DHL-HisZn on mast-cell-mediated type I 
      hypersensitivity was evaluated by a mast-cell degranulation assay using bone 
      marrow-derived mast cells and by a mouse model of ovalbumin (OVA)-induced 
      allergic rhinitis. The effect of DHL-HisZn on the proportion of regulatory T 
      cells (Tregs) was evaluated using flow cytometry. RESULTS: During the course of 
      OVA-induced allergic rhinitis in mice, serum nitrate was elevated, suggesting the 
      involvement of oxidative stress in allergic responses. DHL-HisZn not only 
      suppressed mast-cell degranulation but also ameliorated OVA-induced nasal 
      hypersensitivity, with significant suppression of serum nitrate. DHL-HisZn 
      treatment significantly suppressed OVA-specific immunoglobulin E (IgE) but 
      enhanced OVA-specific IgG2a in OVA-sensitized and nasal-challenged mice. 
      Furthermore, DHL-HisZn treatment suppressed interleukin-17 production in 
      OVA-stimulated splenocytes. Finally, we demonstrated the induction of Tregs by 
      DHL-HisZn in concanavalin A blasts. CONCLUSIONS: These findings suggest that 
      DHL-HisZn may regulate mast-cell-, T-helper 2 (Th2)-, and Th17-mediated allergic 
      and immune responses by induction of Tregs.
CI  - (c) 2017 ARS-AAOA, LLC.
FAU - Nakano, Toshiaki
AU  - Nakano T
AD  - Graduate Institute of Clinical Medical Sciences, Chang Gung University College of 
      Medicine, Kaohsiung, Taiwan.
AD  - Liver Transplantation Center and Department of Surgery, Division of Transplant 
      Immunology, Institute for Translational Research in Biomedicine, Kaohsiung Chang 
      Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, 
      Taiwan.
FAU - Hsu, Li-Wen
AU  - Hsu LW
AD  - Graduate Institute of Clinical Medical Sciences, Chang Gung University College of 
      Medicine, Kaohsiung, Taiwan.
FAU - Lai, Chia-Yun
AU  - Lai CY
AD  - Graduate Institute of Clinical Medical Sciences, Chang Gung University College of 
      Medicine, Kaohsiung, Taiwan.
AD  - Department of Veterinary Medicine, College of Veterinary Medicine, National 
      Pingtung University of Science and Technology, Neipu, Pingtung, Taiwan.
FAU - Takaoka, Yuki
AU  - Takaoka Y
AD  - Graduate Institute of Clinical Medical Sciences, Chang Gung University College of 
      Medicine, Kaohsiung, Taiwan.
FAU - Inomata, Masafumi
AU  - Inomata M
AD  - Department of Gastroenterological and Pediatric Surgery, Faculty of Medicine, 
      Oita University, Yufu, Oita, Japan.
FAU - Kitano, Seigo
AU  - Kitano S
AD  - Oita University, Oita, Japan.
FAU - Chen, Chao-Long
AU  - Chen CL
AD  - Graduate Institute of Clinical Medical Sciences, Chang Gung University College of 
      Medicine, Kaohsiung, Taiwan.
FAU - Goto, Shigeru
AU  - Goto S
AD  - Graduate Institute of Clinical Medical Sciences, Chang Gung University College of 
      Medicine, Kaohsiung, Taiwan.
AD  - Nobeoka Medical Check Center, Fukuoka Institution of Occupational Health, 
      Nobeoka, Miyazaki, Japan.
AD  - Basic Medical Science of Nursing, Faculty of Nursing, Department of Nursing, 
      Josai International University, Togane, Chiba, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170901
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (Allergens)
RN  - 0 (Alum Compounds)
RN  - 0 (Antioxidants)
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulin G)
RN  - 0 (zinc histidine dithiooctanamide)
RN  - 34S289N54E (aluminum sulfate)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4QD397987E (Histidine)
RN  - 73Y7P0K73Y (Thioctic Acid)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Allergens/immunology
MH  - Alum Compounds
MH  - Animals
MH  - Antioxidants/pharmacology/*therapeutic use
MH  - Cell Degranulation/drug effects
MH  - Cytokines/immunology
MH  - Disease Models, Animal
MH  - Female
MH  - Histidine/*analogs & derivatives/pharmacology/therapeutic use
MH  - Immunoglobulin E/blood
MH  - Immunoglobulin G/blood
MH  - Male
MH  - Mast Cells/drug effects/physiology
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/immunology
MH  - Rats, Inbred Lew
MH  - Rhinitis, Allergic/blood/*drug therapy/immunology
MH  - Spleen/cytology/immunology
MH  - T-Lymphocytes, Regulatory/drug effects/immunology
MH  - Thioctic Acid/*analogs & derivatives/pharmacology/therapeutic use
OTO - NOTNLM
OT  - allergic rhinitis
OT  - hypersensitivity
OT  - therapeutics
OT  - type I
OT  - alpha-lipoic acid
EDAT- 2017/09/02 06:00
MHDA- 2018/07/03 06:00
CRDT- 2017/09/02 06:00
PHST- 2017/03/29 00:00 [received]
PHST- 2017/06/26 00:00 [revised]
PHST- 2017/08/10 00:00 [accepted]
PHST- 2017/09/02 06:00 [pubmed]
PHST- 2018/07/03 06:00 [medline]
PHST- 2017/09/02 06:00 [entrez]
AID - 10.1002/alr.22008 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2017 Nov;7(11):1095-1103. doi: 10.1002/alr.22008. Epub 
      2017 Sep 1.