PMID- 2886355
OWN - NLM
STAT- MEDLINE
DCOM- 19870924
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 137
IP  - 2-3
DP  - 1987 Jun 4
TI  - 3,4-Methylenedioxyethylamphetamine (MDE), a novel analogue of MDMA, produces 
      long-lasting depletion of serotonin in the rat brain.
PG  - 265-8
AB  - The present study was carried out to asses possible toxic effects of 
      3,4-methylenedioxyethylamphetamine (MDE) on serotonergic, dopaminergic or 
      noradrenergic neurons in the rat brain. It was found that MDE produced a 
      long-lasting, dose-related depletion of serotonin (5HT). However, even at high 
      dosage, MDE did not reduce the concentration of either dopamine (DA) or 
      norepinephrine (NE) on a long-term basis. When compared to 
      3,4-methylenedioxymethylamphetamine (MDMA), MDE was approximately one fourth as 
      potent as producing a long-term depletion of 5HT. These results suggest that MDE, 
      like MDMA, may be selectively toxic to central serotonergic neurons.
FAU - Ricaurte, G A
AU  - Ricaurte GA
FAU - Finnegan, K F
AU  - Finnegan KF
FAU - Nichols, D E
AU  - Nichols DE
FAU - DeLanney, L E
AU  - DeLanney LE
FAU - Irwin, I
AU  - Irwin I
FAU - Langston, J W
AU  - Langston JW
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Amphetamines)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - ML1I4KK67B (3,4-methylenedioxyethamphetamine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Brain/drug effects/*metabolism
MH  - Dopamine/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Norepinephrine/metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/*metabolism
EDAT- 1987/06/04 00:00
MHDA- 1987/06/04 00:01
CRDT- 1987/06/04 00:00
PHST- 1987/06/04 00:00 [pubmed]
PHST- 1987/06/04 00:01 [medline]
PHST- 1987/06/04 00:00 [entrez]
AID - 0014-2999(87)90233-0 [pii]
AID - 10.1016/0014-2999(87)90233-0 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1987 Jun 4;137(2-3):265-8. doi: 10.1016/0014-2999(87)90233-0.