PMID- 2886406
OWN - NLM
STAT- MEDLINE
DCOM- 19870909
LR  - 20131121
IS  - 0393-5264 (Print)
IS  - 0393-5264 (Linking)
VI  - 1
IP  - 4
DP  - 1986 Oct-Dec
TI  - Excitatory amino acid signal transduction in cerebellar cell cultures.
PG  - 345-9
AB  - In primary cultures of cerebellar granule cells excitatory amino acid recognition 
      sites are coupled with the stimulation of inositol phospholipid (PI) hydrolysis, 
      cGMP formation and 45Ca2+ uptake. Mg2+, 2-amino-5-phosphonovalerate (APV) and 
      phencyclidine (PCP) potently inhibit signal transduction in response to 
      N-methyl-D-aspartate (NMDA), glutamate (GLU) and aspartate (ASP). Activation by 
      quisqualate (QUIS) is transduced selectively into stimulation of PI hydrolysis 
      and this response is not sensitive to inhibition by Mg2+, APV and PCP. Activation 
      by kainate (KA) is transduced into potent stimulation of cGMP formation and 
      45Ca2+ uptake. Transduction of KA signal is not affected by Mg2+ and is 
      relatively insensitive to PCP and APV.
FAU - Nicoletti, F
AU  - Nicoletti F
FAU - Wroblewski, J T
AU  - Wroblewski JT
FAU - Novelli, A
AU  - Novelli A
FAU - Guidotti, A
AU  - Guidotti A
FAU - Costa, E
AU  - Costa E
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Funct Neurol
JT  - Functional neurology
JID - 8707746
RN  - 0 (Amino Acids)
RN  - 0 (Glutamates)
RN  - 0 (Oxadiazoles)
RN  - 0 (Phosphatidylinositols)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 8OC22C1B99 (Quisqualic Acid)
RN  - H2D2X058MU (Cyclic GMP)
RN  - SIV03811UC (Kainic Acid)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Amino Acids/antagonists & inhibitors/*pharmacology
MH  - Animals
MH  - Aspartic Acid/analogs & derivatives/pharmacology
MH  - Calcium/*metabolism
MH  - Cells, Cultured
MH  - Cerebellum/cytology/drug effects/*metabolism
MH  - Cyclic GMP/*metabolism
MH  - Glutamates/pharmacology
MH  - Glutamic Acid
MH  - Kainic Acid/pharmacology
MH  - N-Methylaspartate
MH  - Oxadiazoles/pharmacology
MH  - Phosphatidylinositols/*metabolism
MH  - Quisqualic Acid
MH  - Rats
EDAT- 1986/10/01 00:00
MHDA- 1986/10/01 00:01
CRDT- 1986/10/01 00:00
PHST- 1986/10/01 00:00 [pubmed]
PHST- 1986/10/01 00:01 [medline]
PHST- 1986/10/01 00:00 [entrez]
PST - ppublish
SO  - Funct Neurol. 1986 Oct-Dec;1(4):345-9.