PMID- 2886414
OWN - NLM
STAT- MEDLINE
DCOM- 19870924
LR  - 20191022
IS  - 0018-506X (Print)
IS  - 0018-506X (Linking)
VI  - 21
IP  - 2
DP  - 1987 Jun
TI  - Corticotropin-releasing factor has an anxiogenic action in the social interaction 
      test.
PG  - 193-202
AB  - The effects of intracerebroventricular (icv) injections of 
      corticotropin-releasing factor (CRF, 100 and 300 ng) were investigated in the 
      social interaction test of anxiety in rats. Both doses of CRF significantly 
      decreased active social interaction without a concomitant decrease in locomotor 
      activity. CRF also significantly increased self-grooming, an effect that was 
      independent of the decrease in social interaction. These results indicate an 
      anxiogenic action for CRF. Chlordiazepoxide (CDP, 5 mg/kg ip) pretreatment 
      reversed the anxiogenic effects of icv CRF (100 ng), but CRF did not prevent the 
      sedative effects of CDP. There were no statistically significant changes due to 
      CRF in locomotor activity or rears or head dipping in the holeboard test. Both 
      doses of CRF significantly increased plasma concentrations of corticosterone. The 
      possible mechanisms of the behavioral effects of CRF are discussed.
FAU - Dunn, A J
AU  - Dunn AJ
FAU - File, S E
AU  - File SE
LA  - eng
GR  - MH 25486/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 0 (Anti-Anxiety Agents)
RN  - 6RZ6XEZ3CR (Chlordiazepoxide)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Anti-Anxiety Agents/administration & dosage/*pharmacology
MH  - Chlordiazepoxide/pharmacology
MH  - Corticosterone/blood
MH  - Corticotropin-Releasing Hormone/administration & dosage/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Injections, Intraventricular
MH  - *Interpersonal Relations
MH  - Male
MH  - Motor Activity/drug effects
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1987/06/01 00:00
MHDA- 1987/06/01 00:01
CRDT- 1987/06/01 00:00
PHST- 1987/06/01 00:00 [pubmed]
PHST- 1987/06/01 00:01 [medline]
PHST- 1987/06/01 00:00 [entrez]
AID - 0018-506X(87)90044-4 [pii]
AID - 10.1016/0018-506x(87)90044-4 [doi]
PST - ppublish
SO  - Horm Behav. 1987 Jun;21(2):193-202. doi: 10.1016/0018-506x(87)90044-4.